Keratin, type II cytoskeletal 7

Details

Name
Keratin, type II cytoskeletal 7
Synonyms
  • CK-7
  • Cytokeratin-7
  • K7
  • Keratin-7
  • Sarcolectin
  • SCL
  • Type-II keratin Kb7
Gene Name
KRT7
Organism
Humans
Amino acid sequence
>lcl|BSEQ0037209|Keratin, type II cytoskeletal 7
MSIHFSSPVFTSRSAAFSGRGAQVRLSSARPGGLGSSSLYGLGASRPRVAVRSAYGGPVG
AGIREVTINQSLLAPLRLDADPSLQRVRQEESEQIKTLNNKFASFIDKVRFLEQQNKLLE
TKWTLLQEQKSAKSSRLPDIFEAQIAGLRGQLEALQVDGGRLEAELRSMQDVVEDFKNKY
EDEINHRTAAENEFVVLKKDVDAAYMSKVELEAKVDALNDEINFLRTLNETELTELQSQI
SDTSVVLSMDNSRSLDLDGIIAEVKAQYEEMAKCSRAEAEAWYQTKFETLQAQAGKHGDD
LRNTRNEISEMNRAIQRLQAEIDNIKNQRAKLEAAIAEAEERGELALKDARAKQEELEAA
LQRGKQDMARQLREYQELMSVKLALDIEIATYRKLLEGEESRLAGDGVGAVNISVMNSTG
GSSSGGGIGLTLGGTMGSNALSFSSSAGPGLLKAYSIRTASASRRSARD
Number of residues
469
Molecular Weight
51385.11
Theoretical pI
5.23
GO Classification
Functions
structural molecule activity
Processes
viral process
Components
cytoplasm / extracellular exosome / intermediate filament / keratin filament / nucleus
General Function
Structural molecule activity
Specific Function
Blocks interferon-dependent interphase and stimulates DNA synthesis in cells. Involved in the translational regulation of the human papillomavirus type 16 E7 mRNA (HPV16 E7).
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Cytoplasm
Gene sequence
>lcl|BSEQ0011759|Keratin, type II cytoskeletal 7 (KRT7)
ATGTCCATCCACTTCAGCTCCCCGGTATTCACCTCGCGCTCAGCCGCCTTCTCGGGCCGC
GGCGCCCAGGTGCGCCTGAGCTCCGCTCGCCCCGGCGGCCTTGGCAGCAGCAGCCTCTAC
GGCCTCGGCGCCTCACGGCCGCGCGTGGCCGTGCGCTCTGCCTATGGGGGCCCGGTGGGC
GCCGGCATCCGCGAGGTCACCATTAACCAGAGCCTGCTGGCCCCGCTGCGGCTGGACGCC
GACCCCTCCCTCCAGCGGGTGCGCCAGGAGGAGAGCGAGCAGATCAAGACCCTCAACAAC
AAGTTTGCCTCCTTCATCGACAAGGTGCGGTTTCTGGAGCAGCAGAACAAGCTGCTGGAG
ACCAAGTGGACGCTGCTGCAGGAGCAGAAGTCGGCCAAGAGCAGCCGCCTCCCAGACATC
TTTGAGGCCCAGATTGCTGGCCTTCGGGGTCAGCTTGAGGCACTGCAGGTGGATGGGGGC
CGCCTGGAGGCGGAGCTGCGGAGCATGCAGGATGTGGTGGAGGACTTCAAGAATAAGTAC
GAAGATGAAATTAACCACCGCACAGCTGCTGAGAATGAGTTTGTGGTGCTGAAGAAGGAT
GTGGATGCTGCCTACATGAGCAAGGTGGAGCTGGAGGCCAAGGTGGATGCCCTGAATGAT
GAGATCAACTTCCTCAGGACCCTCAATGAGACGGAGTTGACAGAGCTGCAGTCCCAGATC
TCCGACACATCTGTGGTGCTGTCCATGGACAACAGTCGCTCCCTGGACCTGGACGGCATC
ATCGCTGAGGTCAAGGCGCAGTATGAGGAGATGGCCAAATGCAGCCGGGCTGAGGCTGAA
GCCTGGTACCAGACCAAGTTTGAGACCCTCCAGGCCCAGGCTGGGAAGCATGGGGACGAC
CTCCGGAATACCCGGAATGAGATTTCAGAGATGAACCGGGCCATCCAGAGGCTGCAGGCT
GAGATCGACAACATCAAGAACCAGCGTGCCAAGTTGGAGGCCGCCATTGCCGAGGCTGAG
GAGCGTGGGGAGCTGGCGCTCAAGGATGCTCGTGCCAAGCAGGAGGAGCTGGAAGCCGCC
CTGCAGCGGGGCAAGCAGGATATGGCACGGCAGCTGCGTGAGTACCAGGAACTCATGAGC
GTGAAGCTGGCCCTGGACATCGAGATCGCCACCTACCGCAAGCTGCTGGAGGGCGAGGAG
AGCCGGTTGGCTGGAGATGGAGTGGGAGCCGTGAATATCTCTGTGATGAATTCCACTGGT
GGCAGTAGCAGTGGCGGTGGCATTGGGCTGACCCTCGGGGGAACCATGGGCAGCAATGCC
CTGAGCTTCTCCAGCAGTGCGGGTCCTGGGCTCCTGAAGGCTTATTCCATCCGGACCGCA
TCCGCCAGTCGCAGGAGTGCCCGCGACTGA
Chromosome Location
12
Locus
12q12-q13
External Identifiers
ResourceLink
UniProtKB IDP08729
UniProtKB Entry NameK2C7_HUMAN
GenBank Gene IDAJ238246
GenAtlas IDKRT7
HGNC IDHGNC:6445
General References
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  8. Kanduc D: Translational regulation of human papillomavirus type 16 E7 mRNA by the peptide SEQIKA, shared by rabbit alpha(1)-globin and human cytokeratin 7. J Virol. 2002 Jul;76(14):7040-8. [Article]
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Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB04959Verpasep caltespeninvestigationalunknownDetails
DB01087Primaquineapprovedunknownother/unknownDetails