Carbonyl reductase [NADPH] 1
Details
- Name
- Carbonyl reductase [NADPH] 1
- Synonyms
- 1.1.1.184
- 15-hydroxyprostaglandin dehydrogenase [NADP(+)]
- 20-beta-hydroxysteroid dehydrogenase
- Alcohol dehydrogenase [NAD(P)+] CBR1
- CBR
- CRN
- NADPH-dependent carbonyl reductase 1
- PG-9-KR
- Prostaglandin 9-ketoreductase
- Prostaglandin-E(2) 9-reductase
- SDR21C1
- Short chain dehydrogenase/reductase family 21C member 1
- Gene Name
- CBR1
- UniProtKB Entry
- P16152Swiss-Prot
- Organism
- Humans
- NCBI Taxonomy ID
- 9606
- Amino acid sequence
>lcl|BSEQ0006005|Carbonyl reductase [NADPH] 1 MSSGIHVALVTGGNKGIGLAIVRDLCRLFSGDVVLTARDVTRGQAAVQQLQAEGLSPRFH QLDIDDLQSIRALRDFLRKEYGGLDVLVNNAGIAFKVADPTPFHIQAEVTMKTNFFGTRD VCTELLPLIKPQGRVVNVSSIMSVRALKSCSPELQQKFRSETITEEELVGLMNKFVEDTK KGVHQKEGWPSSAYGVTKIGVTVLSRIHARKLSEQRKGDKILLNACCPGWVRTDMAGPKA TKSPEEGAETPVYLALLPPDAEGPHGQFVSEKRVEQW
- Number of residues
- 277
- Molecular Weight
- 30374.73
- Theoretical pI
- 8.49
- GO Classification
- Functions15-hydroxyprostaglandin dehydrogenase (NADP+) activity / carbonyl reductase (NADPH) activity / oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptorProcessescyclooxygenase pathway / epithelial cell differentiation / vitamin K metabolic processComponentscytosol / extracellular exosome / extracellular vesicle
- General Function
- NADPH-dependent reductase with broad substrate specificity. Catalyzes the reduction of a wide variety of carbonyl compounds including quinones, prostaglandins, menadione, plus various xenobiotics. Catalyzes the reduction of the antitumor anthracyclines doxorubicin and daunorubicin to the cardiotoxic compounds doxorubicinol and daunorubicinol (PubMed:15799708, PubMed:17344335, PubMed:17912391, PubMed:18449627, PubMed:18826943, PubMed:1921984, PubMed:7005231). Can convert prostaglandin E to prostaglandin F2-alpha (By similarity). Can bind glutathione, which explains its higher affinity for glutathione-conjugated substrates. Catalyzes the reduction of S-nitrosoglutathione (PubMed:17344335, PubMed:18826943). In addition, participates in the glucocorticoid metabolism by catalyzing the NADPH-dependent cortisol/corticosterone into 20beta-dihydrocortisol (20b-DHF) or 20beta-corticosterone (20b-DHB), which are weak agonists of NR3C1 and NR3C2 in adipose tissue (PubMed:28878267)
- Specific Function
- 15-hydroxyprostaglandin dehydrogenase (NADP+) activity
- Pfam Domain Function
- adh_short (PF00106)
- Signal Regions
- Not Available
- Transmembrane Regions
- Not Available
- Cellular Location
- Cytoplasm
- Gene sequence
>lcl|BSEQ0012150|Carbonyl reductase [NADPH] 1 (CBR1) ATGTCGTCCGGCATCCATGTAGCGCTGGTGACTGGAGGCAACAAGGGCATCGGCTTGGCC ATCGTGCGCGACCTGTGCCGGCTGTTCTCGGGGGACGTGGTGCTCACGGCGCGGGACGTG ACGCGGGGCCAGGCGGCCGTACAGCAGCTGCAGGCGGAGGGCCTGAGCCCGCGCTTCCAC CAGCTGGACATCGACGATCTGCAGAGCATCCGCGCCCTGCGCGACTTCCTGCGCAAGGAG TACGGGGGCCTGGACGTGCTGGTCAACAACGCGGGCATCGCCTTCAAGGTTGCTGATCCC ACACCCTTTCATATTCAAGCTGAAGTGACGATGAAAACAAATTTCTTTGGTACCCGAGAT GTGTGCACAGAATTACTCCCTCTAATAAAACCCCAAGCATCCTGCGTACTGTCTGCATGG TCATGCCTCTCCCAAAATCCTTCAGGAGGAAAGTCCAAGCCCTTAGCATGGTTCACAGAG ATGTCCATAATCTGCCGCTGCTTAACTCTGGGCCCATTTTAA
- Chromosome Location
- 21
- Locus
- 21q22.12
- External Identifiers
Resource Link UniProtKB ID P16152 UniProtKB Entry Name CBR1_HUMAN GenBank Gene ID J04056 GeneCard ID CBR1 GenAtlas ID CBR1 HGNC ID HGNC:1548 PDB ID(s) 1WMA, 2PFG, 3BHI, 3BHJ, 3BHM, 4Z3D KEGG ID hsa:873 IUPHAR/Guide To Pharmacology ID 1383 NCBI Gene ID 873 - General References
- Wermuth B, Bohren KM, Heinemann G, von Wartburg JP, Gabbay KH: Human carbonyl reductase. Nucleotide sequence analysis of a cDNA and amino acid sequence of the encoded protein. J Biol Chem. 1988 Nov 5;263(31):16185-8. [Article]
- Forrest GL, Akman S, Krutzik S, Paxton RJ, Sparkes RS, Doroshow J, Felsted RL, Glover CJ, Mohandas T, Bachur NR: Induction of a human carbonyl reductase gene located on chromosome 21. Biochim Biophys Acta. 1990 Apr 6;1048(2-3):149-55. [Article]
- Forrest GL, Akman S, Doroshow J, Rivera H, Kaplan WD: Genomic sequence and expression of a cloned human carbonyl reductase gene with daunorubicin reductase activity. Mol Pharmacol. 1991 Oct;40(4):502-7. [Article]
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Associated Data
- Bio-Entities
Bio-Entity Type Carbonyl reductase [NADPH] 1 (Humans) protein primaryCarbonyl reductases (CBRs) (Humans) protein - Drug Relations
Drug Drug group Pharmacological action? Type Actions Details Heptaethylene glycol experimental unknown target Details 2-(2-{2-[2-(2-{2-[2-(2-Ethoxy-Ethoxy)-Ethoxy]-Ethoxy}-Ethoxy)-Ethoxy]-Ethoxy}-Ethoxy)-Ethanol, Polyethyleneglycol Peg400 experimental unknown target Details 3-(4-Amino-1-Tert-Butyl-1h-Pyrazolo[3,4-D]Pyrimidin-3-Yl)Phenol experimental unknown target ligand Details Lubiprostone approved, investigational unknown enzyme substrate Details Acetohexamide approved, investigational, withdrawn unknown enzyme substrate Details 3-(4-Amino-1-Tert-Butyl-1h-Pyrazolo[3,4-D]Pyrimidin-3-Yl)Phenol experimental unknown enzyme binder Details Haloperidol approved unknown enzyme substrate Details Sofalcone investigational unknown enzyme inhibitor Details Tetrabenazine approved, investigational unknown enzyme substrate Details Doxorubicin approved, investigational no enzyme substrate Details Deutetrabenazine approved, investigational unknown enzyme substrate Details Rutin approved, experimental, investigational unknown target Details Resveratrol investigational unknown target inhibitor Details Curcumin approved, investigational unknown target Details Quercetin experimental, investigational unknown target Details Amrubicin investigational unknown enzyme substrate Details Curcumin sulfate experimental unknown target Details Fenofibrate approved unknown enzyme substrate Details Oxcarbazepine approved unknown enzyme substrate Details Loxoprofen approved no enzyme substrate Details Daunorubicin approved unknown enzyme substrate Details N-6022 investigational yes target inhibitor Details