Reaction: Phenytoin arene-oxide to 1 product

Reaction
Phenytoin arene-oxide
DBMET00988
Phenytoin dihydrodiol
DBMET00990
Reaction type
dihydroxylation; oxidation
Direction
Major circulating metabolite?
No
Spontaneous?
No
Activity
unknown
References
  1. Whirl-Carrillo M, McDonagh EM, Hebert JM, Gong L, Sangkuhl K, Thorn CF, Altman RB, Klein TE: Pharmacogenomics knowledge for personalized medicine. Clin Pharmacol Ther. 2012 Oct;92(4):414-7. doi: 10.1038/clpt.2012.96. [Article]
Comments
Not Available
Enzymes
EnzymeKmVmaxRole
Cytochrome P450 1A2Not AvailableNot Availableconfirmed
Cytochrome P450 2A6Not AvailableNot Availableconfirmed
Cytochrome P450 2C19Not AvailableNot Availableconfirmed
Cytochrome P450 2C8Not AvailableNot Availableconfirmed
Cytochrome P450 2C9Not AvailableNot Availableconfirmed
Cytochrome P450 2D6Not AvailableNot Availableconfirmed
Cytochrome P450 2E1Not AvailableNot Availableconfirmed
Cytochrome P450 3A4Not AvailableNot Availableconfirmed
Epoxide hydrolase 1Not AvailableNot Availableconfirmed