Reaction: Doxorubicin to 1 product
- Reaction
- NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial
- NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial
- NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial
- Nitric oxide synthase, endothelial
- Nitric oxide synthase, inducible
- Nitric oxide synthase, brain
- Xanthine dehydrogenase/oxidase
- NAD(P)H dehydrogenase [quinone] 1
- Reaction type
- Not Available
- Direction
- Not Available
- Major circulating metabolite?
- No
- Spontaneous?
- No
- Activity
- unknown
- References
- Whirl-Carrillo M, McDonagh EM, Hebert JM, Gong L, Sangkuhl K, Thorn CF, Altman RB, Klein TE: Pharmacogenomics knowledge for personalized medicine. Clin Pharmacol Ther. 2012 Oct;92(4):414-7. doi: 10.1038/clpt.2012.96. [Article]
- Mordente A, Meucci E, Silvestrini A, Martorana GE, Giardina B: New developments in anthracycline-induced cardiotoxicity. Curr Med Chem. 2009;16(13):1656-72. [Article]
- Minotti G: Reactions of adriamycin with microsomal iron and lipids. Free Radic Res Commun. 1989;7(3-6):143-8. [Article]
- Pawlowska J, Tarasiuk J, Wolf CR, Paine MJ, Borowski E: Differential ability of cytostatics from anthraquinone group to generate free radicals in three enzymatic systems: NADH dehydrogenase, NADPH cytochrome P450 reductase, and xanthine oxidase. Oncol Res. 2003;13(5):245-52. [Article]
- Thornalley PJ, Bannister WH, Bannister JV: Reduction of oxygen by NADH/NADH dehydrogenase in the presence of adriamycin. Free Radic Res Commun. 1986;2(3):163-71. [Article]
- Nohl H, Gille L, Staniek K: The exogenous NADH dehydrogenase of heart mitochondria is the key enzyme responsible for selective cardiotoxicity of anthracyclines. Z Naturforsch C. 1998 Mar-Apr;53(3-4):279-85. [Article]
- Gustafson DL, Swanson JD, Pritsos CA: Role of xanthine oxidase in the potentiation of doxorubicin-induced cardiotoxicity by mitomycin C. Cancer Commun. 1991 Sep;3(9):299-304. doi: 10.3727/095535491820873038. [Article]
- Vasquez-Vivar J, Martasek P, Hogg N, Masters BS, Pritchard KA Jr, Kalyanaraman B: Endothelial nitric oxide synthase-dependent superoxide generation from adriamycin. Biochemistry. 1997 Sep 23;36(38):11293-7. [Article]
- Fogli S, Nieri P, Breschi MC: The role of nitric oxide in anthracycline toxicity and prospects for pharmacologic prevention of cardiac damage. FASEB J. 2004 Apr;18(6):664-75. [Article]
- Miyamoto Y, Koh YH, Park YS, Fujiwara N, Sakiyama H, Misonou Y, Ookawara T, Suzuki K, Honke K, Taniguchi N: Oxidative stress caused by inactivation of glutathione peroxidase and adaptive responses. Biol Chem. 2003 Apr;384(4):567-74. doi: 10.1515/BC.2003.064. [Article]
- Comments
- Not Available
- Enzymes
Enzyme Km Vmax Role NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial Not Available Not Available confirmed NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial Not Available Not Available confirmed NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial Not Available Not Available confirmed Nitric oxide synthase, endothelial Not Available Not Available confirmed Nitric oxide synthase, inducible Not Available Not Available confirmed Nitric oxide synthase, brain Not Available Not Available confirmed Xanthine dehydrogenase/oxidase Not Available Not Available confirmed NAD(P)H dehydrogenase [quinone] 1 Not Available Not Available confirmed
