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Intracellular Signalling Through FSH Receptor and Follicle Stimulating Hormone
smpdb.ca/view/SMP0000333SignalingIn the ovary, the FSH receptor is necessary for follicular development and is expressed on the granulosa cells.
Enzymes: Glycoprotein hormones alpha chain, Serine/threonine-protein phosphatase PP1-alpha catalytic subunitIntracellular Signalling Through LHCGR Receptor and Luteinizing Hormone/Choriogonadotropin
smpdb.ca/view/SMP0000338SignalingLHCGRs are found in the ovary, testis, and many extragonadal tissues.In the ovary, the LHCG receptor is necessary for follicular maturation and ovulation, as well as luteal function. … In the male the LHCGR has been identified on the Leydig cells that are critical for testosterone production, and support spermatogenesis.
Enzymes: Glycoprotein hormones alpha chain, Serine/threonine-protein phosphatase PP1-alpha catalytic subunitMetabolism and Physiological Effects of N-Acetyl-3-Methylhistidine
smpdb.ca/view/SMP0126795MetabolicN-Acetyl-3-methylhistidine, an N-acetyl-L-amino acid, belongs to the class of organic compounds known as histidine and derivatives. … N-Acetyl-3-methylhistidine is an acetylated derivative of 3-methylhistidine and a very strong basic compound (based on its pKa).
Ziconotide NMDA and Substance P Receptor Pain Inhibition Action Pathway
smpdb.ca/view/SMP0126347Drug actionsuch as intrathecal morphine and systemic analgesics. … This causes downstream nociceptive neuronal activity and pain perception. Substance P and CGRP both also induce inflammation, further exasperating chronic pain.
Enzymes: Voltage-dependent N-type calcium channel subunit alpha-1B, Voltage-dependent calcium channel subunit alpha-2/delta-2Icosapent Prostaglandin G/H synthase 1 and 2 anti-inflammatory Action Pathway
smpdb.ca/view/SMP0126557Drug actionThis molecule also inhibits the arachidonic acid conversion into the thromboxane-2 and prostaglandin-2 families because it inhibits the prostaglandin G/H synthase 1 and 2 (COX-1 and COX-2). … Then icosapent shows anti-atherogenic and anti-thrombotic effects in cells. EPA serves as a substrate for Prostaglandin-endoperoxide synthase 1 and 2.
Fish oil Prostaglandin G/H synthase 1 and 2 anti-inflammatory Action Pathway
smpdb.ca/view/SMP0126563Drug actionEPA and DHA do competition with arachidonic acids for both COX-1 and COX-2 enzymes. … These are responsible for the conversion of arachidonic acid (an omega-6 fatty acid) into prostaglandins and thromboxanes, which are important mediators of inflammation and pain.
Ferric pyrophosphate citrate Drug Metabolism
smpdb.ca/view/SMP0130618MetabolicFerric pyrophosphate citrate passes through the liver and is then excreted from the body mainly through the kidney. … Ferric pyrophosphate citrate is a drug that is not metabolized by the human body as determined by current research and biotransformer analysis.
Drugs: Ferric pyrophosphate citratePancreas Function - Alpha Cell
smpdb.ca/view/SMP0121029PhysiologicalThe alpha cell then becomes electrically active due to the closure of potassium channels. The cell membrane becomes depolarized due to voltage dependent sodium, potassium and calcium channels. … Alpha cells are a type of islet cell found in the pancreas that release glucagon. Glucagon counteracts insulin and functions to maintain glucose homeostasis when detected glucose levels are low.
Enzymes: Sodium channel protein type 5 subunit alpha, Alpha-1-syntrophin17-alpha-Hydroxylase Deficiency (CYP17)
smpdb.ca/view/SMP0000566DiseaseWhen mutated, it leads to an accumulation of pregnenolone, progesterone, deoxycorticosterone and 11-dehydrocorticosterone throughout the cell. 17-alpha hydroxylase deficiency is characterized by a deficiency … Treatment with dexamethasone has been able to normalize blood pressure and blood potassium levels. It is estimated that 17-alpha-hydroxylase deficiency affects 1 in 1,000,000 individuals.
Enzymes: Steroid 17-alpha-hydroxylase/17,20 lyasealpha-Arbutin Drug Metabolism
smpdb.ca/view/SMP0130612Metabolicalpha-Arbutin is a drug that is not metabolized by the human body as determined by current research and biotransformer analysis. alpha-Arbutin passes through the liver and is then excreted from the body
Drugs: alpha-Arbutin