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Displaying results 991 - 1000 of 10000 in total
  1. Pathway

    Norepinephrine B2-Adrenergic Artery Dilation Action Pathway

    smpdb.ca/view/SMP0126573
    Drug action

    Norepinephrine is a sympathomimetic used in the control of blood pressure during various hypotensive states and as an adjunct treatment during cardiac arrest. It can be found under the brand name Levophed. Precursor of epinephrine that i...

    Drugs: ATP · Norepinephrine · Potassium cation · Calcium · Magnesium cation · Cyclic adenosine monophosphate
    Enzymes: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
  2. Pathway

    Carteolol B1-Adrenergic Ciliary Muscle Contraction Action Pathway

    smpdb.ca/view/SMP0126647
    Drug action

    By antagonizing the beta-1 adrenergic receptor and blocking G(s) signalling, smooth muscle constriction of the ciliary muscles of the eye make it more difficult for the aqueous humour to reach the eye.

    Drugs: ATP · Carteolol · Potassium cation · Calcium · Magnesium cation · Cyclic adenosine monophosphate
    Enzymes: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
  3. Pathway

    Nadolol B2-Adrenergic Vasoconstriction Action Pathway

    smpdb.ca/view/SMP0126648
    Drug action

    Nadolol is a non-selective beta blocker. It can be administered orally, where it passes through hepatic portal circulation, and enters the bloodstream and travels to act on cardiomyocytes. In bronchial and vascular smooth muscle, nadolol...

    Drugs: ATP · Nadolol · Potassium cation · Calcium · Magnesium cation · Cyclic adenosine monophosphate
    Enzymes: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
  4. Pathway

    Gs Adrenergic Smooth Muscle Relaxation

    smpdb.ca/view/SMP0126934
    Physiological

    The mechanism of adrenoreceptors. Adrenaline or noradrenaline are receptor ligands to either α1, α2 or β-adrenoreceptors. The β receptor couples to Gs and increases intracellular cAMP activity, resulting in e.g. heart muscle contraction,...

    Drugs: ATP · Potassium cation · Calcium · Magnesium cation · Cyclic adenosine monophosphate
    Enzymes: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
  5. Drug

    Butabarbital

    go.drugbank.com/drugs/DB00237
    ApprovedIllicitWithdrawn

    Butabarbital, or Butisol, is a fast onset barbiturate with short duration of action compared to other barbiturates. … [A201977,L13613] Butabarbital is less commonly used in recent years, as more patients are typically prescribed benzodiazepines.

    Categories: Heterocyclic Compounds, 1-RingSynonyms: 5-ethyl-5-(1-methylpropyl)barbituric acid, 5-ethyl-5-(1-methylpropyl)-2,4,6(1H,3H,5H)-pyrimidinetrione
  6. Target

    Mitogen-activated protein kinase kinase kinase 2

    go.drugbank.com/bio_entities/BE0004745
    TargetHumans

    Component of a protein kinase signal transduction cascade. Regulates the JNK and ERK5 pathways by phosphorylating and activating MAP2K5 and MAP2K7 (By similarity). Plays a role in caveolae kiss-and-run dynamics

    Synonyms: MEKK 2, MEK kinase 2
  7. Target

    Mitogen-activated protein kinase kinase kinase 3

    go.drugbank.com/bio_entities/BE0009467
    TargetHumans

    Component of a protein kinase signal transduction cascade. Mediates activation of the NF-kappa-B, AP1 and DDIT3 transcriptional regulators

    Synonyms: MEKK 3, MEK kinase 3
  8. Pathway

    Metipranolol Action Pathway (New)

    smpdb.ca/view/SMP0126208
    Drug action

    Metipranolol is a beta-adrenergic antagonist used for the reduction of elevated intraocular pressure in patients with ocular hypertension or open-angle glaucoma. A beta-adrenergic antagonist effective for both beta-1 and beta-2 receptors...

    Drugs: ATP · Metipranolol · Potassium cation · Calcium · Magnesium cation · Cyclic adenosine monophosphate
    Enzymes: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
  9. Pathway

    Salbutamol Action Pathway

    smpdb.ca/view/SMP0126574
    Drug action

    The R-isomer has 150 times greater affinity for the beta2-receptor than the S-isomer and the S-isomer has been associated with toxicity. … Salbutamol is formulated as a racemic mixture of the R- and S-isomers.

    Drugs: ATP · Albuterol · Potassium cation · Calcium · Magnesium cation · Cyclic adenosine monophosphate
    Enzymes: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
  10. Pathway

    Nylidrin Action Pathway

    smpdb.ca/view/SMP0126575
    Drug action

    Nylidrin is a vasodilator used to treat patients with peripheral vascular disorders, and elderly patients with symptoms associated with organic mental disorders. It can be found under the brand name Arlidin. Nylidrin, also known as buphe...

    Drugs: ATP · Potassium cation · Calcium · Magnesium cation · Cyclic adenosine monophosphate · Nylidrin
    Enzymes: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12