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Quetiapine Dopamine Antagonist Action Pathway
smpdb.ca/view/SMP0126827Drug actionQuetiapine is used in the symptomatic treatment of schizophrenia. In addition, it may be used for the management of acute manic or mixed episodes in patients with bipolar I disorder, as a monotherapy or combined with other drugs. It may ...
Enzymes: Guanine nucleotide-binding protein G(s) subunit alpha isoforms shortDiethylstilbestrol
go.drugbank.com/drugs/DB00255ApprovedWithdrawn(Merck, 11th ed) The FDA withdrew its approval for the use of all oral and parenteral drug products containing 25 milligrams or more of diethylstilbestrol per unit dose.[L43942] … A synthetic nonsteroidal estrogen used in the treatment of menopausal and postmenopausal disorders. It was also used formerly as a growth promoter in animals.
Categories: P-glycoprotein substrates, Cytochrome P-450 SubstratesSynonyms: (E)-3,4-bis(4-hydroxyphenyl)-3-hexene, α,α'-diethyl-(E)-4,4'-stilbenediolBimatoprost
go.drugbank.com/drugs/DB00905ApprovedInvestigationalBimatoprost, also known as Latisse or Lumigan, belongs to a group of drugs called prostamides, which are synthetic structural analogs of prostaglandin. … [L6910] It was initially approved by the FDA in 2001 for ocular hypertension and later approved for hypothrichosis in 2008, as eyelash growth became a desirable adverse effect for patients using this drug
Mixtures: BEMATORİN-T 0,3 MG + 5 MG/1 ML GÖZ DAMLASI, ÇÖZELTİ, 1 ADET, GANFORT®Categories: Cytochrome P-450 Substrates, Prostaglandins F, SyntheticLazertinib
go.drugbank.com/drugs/DB16216ApprovedInvestigational[L51189] Lazertinib is used alone or in combination with other chemotherapeutic agents.[L51184] … Lazertinib is an oral, third-generation, epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI).
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A InhibitorsSynonyms: 2-PROPENAMIDE, N-(5-((4-(4-((DIMETHYLAMINO)METHYL)-3-PHENYL-1H-PYRAZOL-1-YL)-2-PYRIMIDINYL)AMINO)-4-METHOXY-2-(4-MORPHOLINYL)PHENYL)-, N-(5-((4-(4-((DIMETHYLAMINO)METHYL)-3-PHENYL-1H-PYRAZOL-1-YL)PYRIMIDIN-2-YL)AMINO)-4-METHOXY-2-MORPHOLINOPHENYL)ACRYLAMIDEVilazodone mechanism of Action Action Pathway
smpdb.ca/view/SMP0126404Drug actionVilazodone selectively inhibits serotonin reuptake in the central nervous system as well as acting as a partial agonist of 5HT-1A receptors. The exact mechanism for how these effects translate to its antidepressant effects are not known ...
Enzymes: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1Acemetacin
go.drugbank.com/drugs/DB13783ApprovedInvestigationalMerck and Company in Germany as an attempt to provide a safer drug but other than the amelioration on the gastrointestinal effects, the metabolism of acetamicin led to the formation of indomethacin and … Acemetacin is a carboxymethyl ester of indometacin.
Categories: Non COX-2 selective NSAIDS, Heterocyclic Compounds, 2-RingProducts: MERAVILL®, RASLACOF-XSugammadex
go.drugbank.com/drugs/DB06206ApprovedInvestigationalSugammadex (brand name Bridion) is marketed by Merck Sharp and Dohme, and was approved by the United States FDA on December 15, 2015. … Sugammadex is a selective relaxant binding agent indicated for reversal of neuromuscular blockade induced by rocuronium bromide and vecuronium bromide during surgery.
Categories: Compounds used in a research, industrial, or household settingProducts: BRIDION® 200 MG/2 ML SOLUCIÓN PARA INYECCIÓN, MIGAD-XLevodopa Pahway
smpdb.ca/view/SMP0124684Drug actionLevodopa is a dopamine precursor used in the management of Parkinson's disease, often in combination with carbidopa, as well as other conditions associated with parkinsonism. Degeneration of the dopaminergic neurons in substantia nigra o...
Enzymes: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms shortApomorphine Mechanism of Action Action Pathway
smpdb.ca/view/SMP0126633Drug actionApomorphine is a non-ergoline dopamine agonist with high binding affinity to dopamine D2, D3, and D5 receptors. Stimulation of D2 receptors in the caudate-putamen, a region of the brain responsible for locomotor control, may be responsib...
Enzymes: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms shortEpicriptine Mechanism of Action Action Pathway
smpdb.ca/view/SMP0126655Drug actionEpicriptine effect is mainly due to the agonistic activity on dopamine receptor. Epicriptine is also known as beta-dihydroergocryptine presents a molecular formula of 9,10 alpha-dihydro-13'-epi-b-ergocryptine. Together with the alpha-dih...
Enzymes: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short