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Displaying results 1041 - 1050 of 3735 in total
  1. Target

    Vascular endothelial growth factor receptor 3

    go.drugbank.com/bio_entities/BE0000023
    TargetHumans

    The secreted isoform 3 may function as a decoy receptor for VEGFC and/or VEGFD and play an important role as a negative regulator of VEGFC-mediated lymphangiogenesis and angiogenesis. … Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFC and VEGFD, and plays an essential role in adult lymphangiogenesis and in the development of the vascular network and the cardiovascular

    Polypeptides: Vascular endothelial growth factor receptor 3Synonyms: Tyrosine-protein kinase receptor FLT4
  2. Target

    Receptor-type tyrosine-protein kinase FLT3

    go.drugbank.com/bio_entities/BE0000147
    TargetHumans

    Mutations that cause constitutive kinase activity promote cell proliferation and resistance to apoptosis via the activation of multiple signaling pathways … Tyrosine-protein kinase that acts as a cell-surface receptor for the cytokine FLT3LG and regulates differentiation, proliferation and survival of hematopoietic progenitor cells and of dendritic cells.

    Polypeptides: Receptor-type tyrosine-protein kinase FLT3Synonyms: FL cytokine receptor
  3. Target

    Sigma non-opioid intracellular receptor 1

    go.drugbank.com/bio_entities/BE0000290
    TargetHumans

    Functions in lipid transport from the endoplasmic reticulum and is involved in a wide array of cellular functions probably through regulation of the biogenesis of lipid microdomains at the plasma membrane. Regulates calcium efflux at the...

    Polypeptides: Sigma non-opioid intracellular receptor 1Synonyms: Sigma 1-type opioid receptor, Sigma non-opioid intracellular receptor 1
  4. Target

    Vascular endothelial growth factor receptor 2

    go.drugbank.com/bio_entities/BE0000369
    TargetHumans

    Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFC and VEGFD.

    Polypeptides: Vascular endothelial growth factor receptor 2Synonyms: Kinase insert domain receptor, Protein-tyrosine kinase receptor flk-1
  5. Target

    Taste receptor type 1 member 2

    go.drugbank.com/bio_entities/BE0000395
    TargetHumans

    Key component of the sweet taste receptor (PubMed:11917125, PubMed:40339580, PubMed:40754567, PubMed:40555359). … Functions as a G protein-coupled receptor and primarily signals through the gustducin heterotrimer (PubMed:40339580)

    Polypeptides: Taste receptor type 1 member 2Synonyms: Sweet taste receptor T1R2, G protein-coupled receptor 71
  6. Target

    Neuronal acetylcholine receptor subunit beta-2

    go.drugbank.com/bio_entities/BE0000850
    TargetHumans

    Component of neuronal acetylcholine receptors (nAChRs) that function as pentameric, ligand-gated cation channels with high calcium permeability among other activities. nAChRs are excitatory neurotrasnmitter receptors formed by a collecti...

    Polypeptides: Neuronal acetylcholine receptor subunit beta-2
  7. Target

    Platelet-derived growth factor receptor alpha

    go.drugbank.com/bio_entities/BE0000852
    TargetEnzymeHumans

    Receptor signaling is down-regulated by protein phosphatases that dephosphorylate the receptor and its down-stream effectors, and by rapid internalization of the activated receptor … Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis

    Polypeptides: Platelet-derived growth factor receptor alphaSynonyms: Alpha platelet-derived growth factor receptor, Platelet-derived growth factor receptor 2
  8. Target

    Macrophage colony-stimulating factor 1 receptor

    go.drugbank.com/bio_entities/BE0000853
    TargetHumans

    Activated CSF1R transmits signals both via proteins that directly interact with phosphorylated tyrosine residues in its intracellular domain, or via adapter proteins, such as GRB2. … Receptor signaling is down-regulated by protein phosphatases, such as INPP5D/SHIP-1, that dephosphorylate the receptor and its downstream effectors, and by rapid internalization of the activated receptor

    Polypeptides: Macrophage colony-stimulating factor 1 receptorSynonyms: CSF-1 receptor
  9. Target

    Epithelial discoidin domain-containing receptor 1

    go.drugbank.com/bio_entities/BE0001124
    TargetHumans

    Tyrosine kinase that functions as a cell surface receptor for fibrillar collagen and regulates cell attachment to the extracellular matrix, remodeling of the extracellular matrix, cell migration, differentiation

    Polypeptides: Epithelial discoidin domain-containing receptor 1Synonyms: Discoidin receptor tyrosine kinase, Epithelial discoidin domain receptor 1
  10. Target

    Ferrichrome outer membrane transporter/phage receptor

    go.drugbank.com/bio_entities/BE0001326
    TargetEscherichia coli (strain K12)

    In addition to its role in ferrichrome-iron transport, transports the antibiotic albomycin, which is a structural analog of ferrichrome, and acts as a receptor for colicin M, microcin J25 and bacteriophages

    Polypeptides: Ferrichrome outer membrane transporter/phage receptorSynonyms: Ferric hydroxamate receptor, Ferrichrome-iron receptor