Search
Signal transducer and activator of transcription 5B
go.drugbank.com/bio_entities/BE0000891TargetHumansSignal transducer and transcription activator that mediates cellular responses to cytokines, hormones and growth factors (PubMed:29844444, PubMed:9188471). … Binds to the GAS element and activates PRL-induced transcription. Positively regulates hematopoietic/erythroid differentiation.
Polypeptides: Signal transducer and activator of transcription 5BDisintegrin and metalloproteinase domain-containing protein 10
go.drugbank.com/bio_entities/BE0002404TargetHumansResponsible for the proteolytic release of several other cell-surface proteins, including heparin-binding epidermal growth-like factor, ephrin-A2, CD44, CDH2 and for constitutive and regulated alpha-secretase … Involved in the cleavage of the adhesion molecule L1 at the cell surface and in released membrane vesicles, suggesting a vesicle-based protease activity (PubMed:12475894).
Polypeptides: Disintegrin and metalloproteinase domain-containing protein 10Disintegrin and metalloproteinase domain-containing protein 28
go.drugbank.com/bio_entities/BE0003872TargetHumansMay play a role in the adhesive and proteolytic events that occur during lymphocyte emigration or may function in ectodomain shedding of lymphocyte surface target proteins, such as FASL and CD40L.
Polypeptides: Disintegrin and metalloproteinase domain-containing protein 28Synonyms: Metalloproteinase-like, disintegrin-like, and cysteine-rich protein L, Epididymal metalloproteinase-like, disintegrin-like, and cysteine-rich protein IISodium- and chloride-dependent GABA transporter 2
go.drugbank.com/bio_entities/BE0004776TargetHumansCan also mediate transport of taurine and hypotaurine (By similarity) … Mediates sodium- and chloride-dependent transport of gamma-aminobutyric acid (GABA) (PubMed:17502375, PubMed:22932902). Mediates transport of beta-alanine (PubMed:17502375).
Polypeptides: Sodium- and chloride-dependent GABA transporter 2Sodium- and chloride-dependent glycine transporter 1
go.drugbank.com/bio_entities/BE0000940TransporterTargetHumansSodium- and chloride-dependent glycine transporter (PubMed:37962965, PubMed:8183239). Essential for regulating glycine concentrations at inhibitory glycinergic synapses
Polypeptides: Sodium- and chloride-dependent glycine transporter 1Troponin C, slow skeletal and cardiac muscles
go.drugbank.com/bio_entities/BE0001024TargetHumansThe binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments … Tn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C.
Polypeptides: Troponin C, slow skeletal and cardiac musclesSodium- and chloride-dependent glycine transporter 2
go.drugbank.com/bio_entities/BE0002310TransporterTargetHumansSodium- and chloride-dependent glycine transporter (PubMed:10381548, PubMed:10606742, PubMed:16751771, PubMed:31370103, PubMed:9845349).
Polypeptides: Sodium- and chloride-dependent glycine transporter 2Signal transducer and activator of transcription 3
go.drugbank.com/bio_entities/BE0003462TargetHumansand IL6ST) (PubMed:9188471) … Following JAK/STAT signaling activation and as part of a complex with NFATC3 and NFATC4, binds to the alpha-beta E4 promoter region of CRYAB and activates transcription in cardiomyocytes (By similarity
Polypeptides: Signal transducer and activator of transcription 3Disintegrin and metalloproteinase domain-containing protein 17
go.drugbank.com/bio_entities/BE0003754TargetHumansResponsible for the proteolytical release of soluble JAM3 from endothelial cells surface (PubMed:20592283). … Mediates the proteolytic cleavage and shedding of FCGR3A upon NK cell stimulation, a mechanism that allows for increased NK cell motility and detachment from opsonized target cells.
Polypeptides: Disintegrin and metalloproteinase domain-containing protein 17Macrophage scavenger receptor types I and II
go.drugbank.com/bio_entities/BE0010942TargetHumansRecognizes and internalizes modified forms of low-density lipoproteins including acetylated LDL (AcLDL) and oxidized LDL (OxLDL), thereby promoting cholesterol uptake and contributing to foam cell formation … Binds various pathogen-associated and damage-associated molecules, including bacterial cell wall components, apoptotic cell debris and polyanionic ligands, supporting macrophage clearance activity in innate
Polypeptides: Macrophage scavenger receptor types I and IISynonyms: Macrophage acetylated LDL receptor I and II