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Displaying results 101 - 110 of 134502 in total
  1. Pathway

    Intracellular Signalling Through LHCGR Receptor and Luteinizing Hormone/Choriogonadotropin

    smpdb.ca/view/SMP0000338
    Signaling

    LHCGRs are found in the ovary, testis, and many extragonadal tissues.In the ovary, the LHCG receptor is necessary for follicular maturation and ovulation, as well as luteal function. … In the male the LHCGR has been identified on the Leydig cells that are critical for testosterone production, and support spermatogenesis.

    Drugs: ATP · Magnesium cation · Cyclic adenosine monophosphate · Pyrophosphoric acid
  2. Pathway

    Metabolism and Physiological Effects of N-Acetyl-3-Methylhistidine

    smpdb.ca/view/SMP0126795
    Metabolic

    N-Acetyl-3-methylhistidine, an N-acetyl-L-amino acid, belongs to the class of organic compounds known as histidine and derivatives. … N-Acetyl-3-methylhistidine is an acetylated derivative of 3-methylhistidine and a very strong basic compound (based on its pKa).

    Drugs: Histidine · Ademetionine
  3. Pathway

    Metabolism and Physiological Effects of N-alpha-Acetyl-L-arginine

    smpdb.ca/view/SMP0125530
    Metabolic

    Arginnosuccinate is synthesized from citrulline and aspartic acid by the enzyme argininosuccinate synthase. That is catalyzed by argininosuccinate lyase to produce arginine and fumaric acid. … In the blood it works as a uremic toxin to cause kidney damage, cardiovascular disease and neurological deficits.

    Drugs: Pyridoxal phosphate · Arginine · Aspartic acid · Ornithine · L-Glutamine · Adenosine phosphate +10 more
  4. Pathway

    Ziconotide NMDA and Substance P Receptor Pain Inhibition Action Pathway

    smpdb.ca/view/SMP0126347
    Drug action

    such as intrathecal morphine and systemic analgesics. … This causes downstream nociceptive neuronal activity and pain perception. Substance P and CGRP both also induce inflammation, further exasperating chronic pain.

    Drugs: Glutamic acid · Calcium · Sar9, Met (O2)11-Substance P · Ziconotide
  5. Pathway

    Icosapent Prostaglandin G/H synthase 1 and 2 anti-inflammatory Action Pathway

    smpdb.ca/view/SMP0126557
    Drug action

    This molecule also inhibits the arachidonic acid conversion into the thromboxane-2 and prostaglandin-2 families because it inhibits the prostaglandin G/H synthase 1 and 2 (COX-1 and COX-2). … Then icosapent shows anti-atherogenic and anti-thrombotic effects in cells. EPA serves as a substrate for Prostaglandin-endoperoxide synthase 1 and 2.

    Drugs: Glutathione · Icosapent · Dinoprostone · Calcium · Mesoheme · Prostaglandin G2 +1 more
  6. Pathway

    Fish oil Prostaglandin G/H synthase 1 and 2 anti-inflammatory Action Pathway

    smpdb.ca/view/SMP0126563
    Drug action

    EPA and DHA do competition with arachidonic acids for both COX-1 and COX-2 enzymes. … These are responsible for the conversion of arachidonic acid (an omega-6 fatty acid) into prostaglandins and thromboxanes, which are important mediators of inflammation and pain.

    Drugs: Glutathione · Icosapent · Dinoprostone · Calcium · Mesoheme · Prostaglandin G2 +1 more
  7. Pathway

    Pantoprazole Action Pathway

    smpdb.ca/view/SMP0123293
    Drug action

    In parietal cells, carbonic anhydrase converts water and carbon dioxide to hydrogen bicarbonate ions and H+. … The H+/K+ ATPase is located on the apical membrane and pumps the H+ from the cell into the stomach lumen and K+ from the lumen into the cell.

    Drugs: Pantoprazole · Potassium cation · Zinc
    Enzymes: Potassium-transporting ATPase alpha chain 1, Potassium-transporting ATPase subunit beta
  8. Pathway

    Rabeprazole Antacid Action Pathway

    smpdb.ca/view/SMP0123294
    Drug action

    In parietal cells, carbonic anhydrase converts water and carbon dioxide to hydrogen bicarbonate ions and H+. … The H+/K+ ATPase is located on the apical membrane and pumps the H+ from the cell into the stomach lumen and K+ from the lumen into the cell.

    Drugs: Rabeprazole · Potassium cation · Zinc
    Enzymes: Potassium-transporting ATPase alpha chain 1, Potassium-transporting ATPase subunit beta
  9. Pathway

    Kidney Function - Distal Convoluted Tubule

    smpdb.ca/view/SMP0121012
    Physiological

    As a result, a high concentration of sodium, chlorine, and calcium in the blood vessels occurs. The reabsorption of ions and water increases blood fluid volume and blood pressure. … In addition, sodium, chlorine, and calcium are also reabsorbed back into the systemic circulation via their respective channels and exchangers.

    Drugs: Potassium cation · Calcium · Urea
    Enzymes: Potassium-transporting ATPase alpha chain 1, Potassium-transporting ATPase subunit beta
  10. Pathway

    Lactose Degradation

    smpdb.ca/view/SMP0000457
    Metabolic

    A sodium/potassium ATPase makes ATP by moving three sodium ions to the blood per two potassium ions that cross into the epithelial cell, giving the GLUT1 transporter energy to work. … GLUT1 actively transports glucose and galactose with 2 sodium ions.

    Drugs: ATP · Potassium cation · Lactose
    Enzymes: Sodium/potassium-transporting ATPase subunit alpha-1, Sodium/potassium-transporting ATPase subunit beta-1