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Displaying results 101 - 110 of 606 in total
  1. Target

    Leukemia inhibitory factor receptor

    go.drugbank.com/bio_entities/BE0013220
    TargetHumans

    Functions as a membrane-bound signal-transducing subunit either in complex with IL6ST/gp130 or as part of the ciliary neurotrophic factor receptor (CNTFR) complex composed by CNTFR, IL6ST/gp130 and LIFR … The tyrosine phosphorylated signaling receptors serve in turn as docking sites for recruitment and activation of signal transducer and activators of transcription (STATs) (PubMed:11285233, PubMed:11294841

    Polypeptides: Leukemia inhibitory factor receptorFunction: ciliary neurotrophic factor receptor binding
  2. Target

    Transcription factor Spi-B

    go.drugbank.com/bio_entities/BE0013918
    TargetHumans

    These cells have the capacity to produce large amounts of interferon and block viral replication. … May be required for B-cell receptor (BCR) signaling, which is necessary for normal B-cell development and antigenic stimulation

    Polypeptides: Transcription factor Spi-B
  3. Target

    Pro-epidermal growth factor

    go.drugbank.com/bio_entities/BE0000953
    TargetHumans

    EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. … Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6.

    Polypeptides: Pro-epidermal growth factor
  4. Target

    Fibroblast growth factor 2

    go.drugbank.com/bio_entities/BE0001015
    TargetHumans

    Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4 (PubMed:8663044). Also acts as an integrin ligand which is required for FGF2 signaling (PubMed:28302677). … Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration (PubMed:28302677, PubMed:8663044).

    Polypeptides: Fibroblast growth factor 2Synonyms: Basic fibroblast growth factor, Heparin-binding growth factor 2
  5. Target

    Elongation factor Tu-B

    go.drugbank.com/bio_entities/BE0001735
    TargetThermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)

    This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

    Polypeptides: Elongation factor Tu-B
  6. Target

    Macrophage migration inhibitory factor

    go.drugbank.com/bio_entities/BE0001855
    TargetHumans

    It is not clear whether the tautomerase activity has any physiological relevance, and whether it is important for cytokine activity (PubMed:11439086, PubMed:17526494) … Has phenylpyruvate tautomerase and dopachrome tautomerase activity (in vitro), but the physiological substrate is not known (PubMed:11439086, PubMed:17526494).

    Polypeptides: Macrophage migration inhibitory factorSynonyms: Glycosylation-inhibiting factor
  7. Target

    Release factor glutamine methyltransferase

    go.drugbank.com/bio_entities/BE0002514
    TargetThermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)

    Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif.

    Polypeptides: Release factor glutamine methyltransferase
  8. Target

    Peptidoglycan editing factor PgeF

    go.drugbank.com/bio_entities/BE0002757
    TargetEscherichia coli (strain K12)

    Purine nucleoside enzyme that catalyzes the phosphorolysis of adenosine and inosine nucleosides, yielding D-ribose 1-phosphate and the respective free bases, adenine and hypoxanthine (PubMed:31978345). … May also act as a polyphenol oxidase: able to oxidize syringaldazine and 2,2'-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) (ABTS) in vitro (PubMed:16740638).

    Polypeptides: Peptidoglycan editing factor PgeFSynonyms: PG-editing factor
  9. Target

    Elongation factor Tu, mitochondrial

    go.drugbank.com/bio_entities/BE0004542
    TargetHumans

    Recruits ATG5-ATG12 and NLRX1 at mitochondria and serves as a checkpoint of the RIGI-MAVS pathway (PubMed:28407488). … Also plays a role in the regulation of autophagy and innate immunity (PubMed:22749352, PubMed:28407488).

    Polypeptides: Elongation factor Tu, mitochondrial
  10. Target

    Fibroblast growth factor 19

    go.drugbank.com/bio_entities/BE0005820
    TargetHumans

    Activity requires the presence of KLB and FGFR4 … Involved in the suppression of bile acid biosynthesis through down-regulation of CYP7A1 expression, following positive regulation of the JNK and ERK1/2 cascades.

    Polypeptides: Fibroblast growth factor 19Function: fibroblast growth factor receptor binding