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Demecarium Action Pathway (new)
smpdb.ca/view/SMP0126687Drug actionDemecarium is a cholinesterase inhibitor used in the treatment of glaucoma, acting as an indirect parasympathomimetic agent by increasing acetylcholine levels in the synaptic cleft. The mechanism of action is demecarium the drug acts on ...
Enzymes: Voltage-dependent L-type calcium channel subunit beta-4, Voltage-dependent L-type calcium channel subunit beta-1Rivastigmine Action Pathway (new)
smpdb.ca/view/SMP0126688Drug actionRivastigmine is a cholinesterase inhibitor used in the treatment of symptoms of dementia in Alzheimer's and Parkinson's. The drug reversible binds to and inhibits acetylcholinesterase and cholinesterase which stops the breakdown of acety...
Enzymes: Voltage-dependent L-type calcium channel subunit beta-4, Voltage-dependent L-type calcium channel subunit beta-1Echothiophate Action Pathway
smpdb.ca/view/SMP0126704Drug actionEchothiophate also known as phospholine iodide is an acetylcholinesterase inhibitor, used in the treatment of glaucoma in order to increase the drainage of intraocular fluid. It is administered via eye drops and acts on acetylcholinester...
Enzymes: Voltage-dependent L-type calcium channel subunit beta-4, Voltage-dependent L-type calcium channel subunit beta-1Phenserine Action Pathway
smpdb.ca/view/SMP0126724Drug actionPhenserine is a next-generation acetylcholinesterase, used to treat dementia. It acts as a highly selective reversible acetylcholinesterase inhibitor, which is known to increase acetylcholine levels in the synaptic cleft and enhance the ...
Enzymes: Voltage-dependent L-type calcium channel subunit beta-4, Voltage-dependent L-type calcium channel subunit beta-1Doxylamine H1 Antihistamine Neurological Sleep Action Pathway
smpdb.ca/view/SMP0126738Drug actionDoxylamine is an ethanolamine class H1 antihistamine used to treat insomnia and allergy symptoms such as hay fever and hives. It is also used with pyridoxine in the treatment of nausea and vomiting in pregnancy. H1-antihistamines interfe...
Enzymes: Voltage-dependent calcium channel subunit alpha-2/delta-1, Voltage-dependent N-type calcium channel subunit alpha-1BPheniramine H1 Antihistamine Neurological Sleep Action Pathway
smpdb.ca/view/SMP0145419Drug actionPheniramine is an ethanolamine class H1 antihistamine used to treat insomnia and allergy symptoms such as hay fever and hives. It is also used with pyridoxine in the treatment of nausea and vomiting in pregnancy. H1-antihistamines interf...
Enzymes: Voltage-dependent calcium channel subunit alpha-2/delta-1, Voltage-dependent N-type calcium channel subunit alpha-1BTrimipramine H1 Antihistamine Neurological Sleep Action Pathway
smpdb.ca/view/SMP0145431Drug actionTrimipramine is an ethanolamine class H1 antihistamine used to treat insomnia and allergy symptoms such as hay fever and hives. It is also used with pyridoxine in the treatment of nausea and vomiting in pregnancy. H1-antihistamines inter...
Enzymes: Voltage-dependent calcium channel subunit alpha-2/delta-1, Voltage-dependent N-type calcium channel subunit alpha-1BOsteodystrophy
go.drugbank.com/conditions/DBCOND0016488Repaglinide Action Pathway
smpdb.ca/view/SMP0000454Drug actionDepolarization causes opening of voltage-gated calcium channels, allowing calcium to enter cell. High intracellular calcium subsequently stimulate vesicle exocytosis and insulin secretion.
Enzymes: Voltage-dependent P/Q-type calcium channel subunit alpha-1A, Voltage-dependent L-type calcium channel subunit beta-1Pancreas Function - Delta Cell
smpdb.ca/view/SMP0121128PhysiologicalThe resulting action potential from the increased membrane potential causes the voltage gate calcium channels to open, creating an influx of calcium into the cell. … Somatostatin is stored in granules in the delta cell and is released in response to an increase in blood sugar, calcium, and blood amino acids during absorption of a meal.
Enzymes: Voltage-dependent P/Q-type calcium channel subunit alpha-1A, Voltage-dependent L-type calcium channel subunit beta-1