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Glutethimide Action Pathway
smpdb.ca/view/SMP0126131Drug actionGlutethimide is a hypnotic and sedative. Its use has been largely superseded by other drugs. It can be found under the brand name Doriden and is used to treat insomnia. The hypnotic effect is roughly analogous to that of pentobarbital. I...
Enzymes: Vesicular inhibitory amino acid transporter, Gamma-aminobutyric acid type B receptor subunit 2Prazepam Action Pathway
smpdb.ca/view/SMP0126137Drug actionPrazepam is a benzodiazepine used to manage more severe forms of anxiety disorders. Prazepam is a benzodiazepine derivative with anxiolytic, anticonvulsant, sedative and skeletal muscle relaxant activity. It can be found under the brand ...
Enzymes: Vesicular inhibitory amino acid transporter, Gamma-aminobutyric acid type B receptor subunit 2Stiripentol GABA(A) Antiepileptic Action Pathway
smpdb.ca/view/SMP0126168Drug actionPossible mechanisms of action include direct effects mediated through the gamma-aminobutyric acid GABAA receptor and indirect effects involving inhibition of cytochrome P450 activity.
Drugs: Pyridoxal phosphate · Glutamic acid · ATP · Calcium · Magnesium cation · Cyclic adenosine monophosphate +4 moreEnzymes: Vesicular inhibitory amino acid transporter, Gamma-aminobutyric acid type B receptor subunit 2Metabolsim and Physiological Effects of 4-Ethylphenylsulfate
smpdb.ca/view/SMP0125541Metabolicacid. … This is metabolized into phenylpyruvic acid Phenylacetic acid which is then metabolized into 3-(3-Hydroxyphenyl)propanoic acid.
Drugs: Pyridoxal phosphate · Phenylalanine · Tyrosine · Iron · Oxogluric acid · Propanoic acid +3 moreEnzymes: Aromatic-amino-acid aminotransferaseBrexanolone Action Pathway
smpdb.ca/view/SMP0126148Drug actionBrexanolone can be found under the brand name Zulresso, and it is the first drug to have ever been approved by the US FDA specifically for the treatment of postpartum depression (PPD) in adult females. Since PPD, like various other types...
Drugs: Pyridoxal phosphate · Glutamic acid · ATP · Progesterone · Calcium · Magnesium cation +4 moreEnzymes: Vesicular inhibitory amino acid transporter, Gamma-aminobutyric acid type B receptor subunit 2Phenylketonuria
smpdb.ca/view/SMP0125602DiseaseIt is also characterized by an accumulation of Phenylpyruvic acid, Mandelic acid, Phenylacetic acid, Phenylacetylglutamine, and Glycine in the blood and urine.
Drugs: Pyridoxal phosphate · Phenylalanine · L-Glutamine · Adenosine phosphate · Tyrosine · Glutamic acid +17 moreEnzymes: L-amino-acid oxidase, Y+L amino acid transporter 1Gemfibrozil Action Pathway
smpdb.ca/view/SMP0125290Drug actionFatty acid metabolism is also increased due to upregulation of acyl coA synthase, an enzyme involved in fatty acid oxidation. … PPARα binds to the retinoic acid receptor alpha (RXRα).
Enzymes: Retinoic acid receptor RXR-beta, Retinoic acid receptor RXR-alphaPrimidone Action Pathway
smpdb.ca/view/SMP0126166Drug actionPrimidone is an antiepileptic used to treat grand mal, psychomotor, and focal epileptic seizures. Primidone alters sodium and calcium channel transport, reducing the frequency of nerve firing, which may be responsible for its effect on c...
Enzymes: Vesicular inhibitory amino acid transporter, Gamma-aminobutyric acid type B receptor subunit 2Fenofibrate Action Pathway
smpdb.ca/view/SMP0125276Drug actionFatty acid metabolism is also increased due to upregulation of acyl coA synthase, an enzyme involved in fatty acid oxidation. … PPARα binds to the retinoic acid receptor alpha (RXRα).
Enzymes: Retinoic acid receptor RXR-beta, Retinoic acid receptor RXR-alphaBezafibrate Action Pathway (New)
smpdb.ca/view/SMP0125291Drug actionFatty acid metabolism is also increased due to upregulation of acyl coA synthase, an enzyme involved in fatty acid oxidation. … PPARα binds to the retinoic acid receptor alpha (RXRα).
Enzymes: Retinoic acid receptor RXR-beta, Retinoic acid receptor RXR-alpha