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Displaying results 101 - 110 of 1182 in total
  1. Drug

    Inolimomab

    go.drugbank.com/drugs/DB15628
    Investigational

    Inolimomab is under investigation as an agent to treat steroid-resistant graft vs host disease. It has thus far offered similar efficacy to other monoclonal antibody options, though it may carry a higher risk of infections.

    Synonyms: Immunoglobulin G1, anti-(human interleukin 2 receptor alpha-chain) (mouse monoclonal B-B10 gammal-chain), disulfide with mouse monoclonal B-B10 kappa-chain, dimer
  2. Indication

    Herpes Zoster

    go.drugbank.com/conditions/DBCOND0028191
    Drugs: Acyclovir · Brivudine · Econazole · Famciclovir · Lysozyme · Ox bile extract +3 more
    Synonyms: Zoster [herpes zoster], Zoster
  3. Drug

    Receptor binding domain (RBD) SARS-CoV-2 (COVID-19) hepatitis B surface antigen (HBsAg) virus-like particle (VLP) vaccine

    go.drugbank.com/drugs/DB16431
    Experimental

    Regarding this vaccine specifically, it stimulates the immune system to produce anti-receptor binding domain antibodies[A226593]. … Receptor binding domain SARS-CoV-2 Hepatitis B surface antigen virus-like particle vaccine (RBD SARS-CoV-2 HBsAg VLP vaccine), is a virus-like particle vaccine candidate where the RBD antigen is conjugated

  4. Drug

    Pulocimab

    go.drugbank.com/drugs/DB18938
    Investigational

    Pulocimab is under investigation in clinical trial NCT06341335 (A Study of Ak104/placebo Plus Ak109/placebo and Paclitaxel in Gastric or Gastroesophageal Junction Adenocarcinoma).

    Synonyms: Immunoglobulin g1, anti-(human vascular endothelial growth factor receptor 2) (human monoclonal ak109 .gamma.1-chain), disulfide with human monoclonal ak109 .kappa.-chain, dimer
  5. Pathway

    Intracellular Signalling Through FSH Receptor and Follicle Stimulating Hormone

    smpdb.ca/view/SMP0000333
    Signaling

    In the ovary, the FSH receptor is necessary for follicular development and is expressed on the granulosa cells. … In the male the FSH receptor has been identified on the Sertoli cells that are critical for spermatogenesis.

    Drugs: ATP · Magnesium cation · Cyclic adenosine monophosphate · Pyrophosphoric acid
    Enzymes: Follicle-stimulating hormone receptor
  6. Pathway

    Intracellular Signalling Through LHCGR Receptor and Luteinizing Hormone/Choriogonadotropin

    smpdb.ca/view/SMP0000338
    Signaling

    LHCGRs are found in the ovary, testis, and many extragonadal tissues.In the ovary, the LHCG receptor is necessary for follicular maturation and ovulation, as well as luteal function. … The LHCGRs receptor activates G(s) proteins which lead to the activation of Adenylyl cyclase which produces the secondary messenger cAMP. cAMP activates PKA (Protein Kinase A) which phosphorylates down

    Drugs: ATP · Magnesium cation · Cyclic adenosine monophosphate · Pyrophosphoric acid
    Enzymes: Lutropin-choriogonadotropic hormone receptor
  7. Drug

    Talc

    go.drugbank.com/drugs/DB09511
    ApprovedInvestigational

    In fact, recent studies have reported that talc increases the risk of ovarian and endometrial cancers by approximately 30 percent.

  8. Drug

    KITE-222

    go.drugbank.com/drugs/DB17195
    Investigational

    Synonyms: An autologous chimeric antigen receptor (CAR) T-cell therapy engineered to express an antibody-derived single-chain variable fragment that recognizes C-type lectin-like molecule-1 (CLL-1)
  9. Drug

    Mirvetuximab

    go.drugbank.com/drugs/DB16235
    Investigational

    Synonyms: Immunoglobulin g1, anti-(human folate receptor .alpha.) (human-mus musculus monoclonal m9346a heavy chain), disulfide with human-mus musculus monoclonal m9346a light chain, dimer
  10. Pathway

    Ziconotide NMDA and Substance P Receptor Pain Inhibition Action Pathway

    smpdb.ca/view/SMP0126347
    Drug action

    Ziconotide, also known as SNX-111, is an N-type calcium channel antagonist used to manage patients with severe chronic pain who cannot tolerate, or who have not responded adequately to other treatments such as intrathecal morphine and sy...

    Drugs: Glutamic acid · Calcium · Sar9, Met (O2)11-Substance P · Ziconotide
    Enzymes: Substance-P receptor, Glutamate [NMDA] receptor subunit 3B