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Solriamfetol Action Pathway
smpdb.ca/view/SMP0126346Drug actionSolriamfetol, also known as Sunosi, is a dopamine and norepinephrine reuptake inhibitor (DNRI). This drug is indicated for the daytime treatment of sleepiness associated with narcolepsy or obstructive sleep apnea. Solriamfetol was given ...
Enzymes: Guanine nucleotide-binding protein G(s) subunit alpha isoforms shortCaffeine Cardiac Contraction Action Pathway
smpdb.ca/view/SMP0126520Drug actionCaffeine is a stimulant present in tea, coffee, cola beverages, analgesic drugs, and agents used to increase alertness. The cardiovascular effects are extensive and can help with headaches, migraines, or other types of pain in certain ci...
Enzymes: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1Cocaine Dopamine-reuptake Inhibitor Action Pathway
smpdb.ca/view/SMP0126543Drug actionCocaine is a local anesthesia and vasoconstrictor that is clinically used during diagnostic proceedures or during surgery in or through the nasal cavity. It comes in drugs called Goprelto and Numbrino which comes as a nasal spray. In the...
Enzymes: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1Benzatropine Dopamine Reuptake Inhibitor Action Pathway
smpdb.ca/view/SMP0126985Drug actionBenzatropine, known commonly as Cogentin, is an anticholinergic drug used to treat Parkinson's disease and extrapyramidal symptoms, except tardive dyskinesia. Benzatropine is used in therapy for parkinsonism, referring to a group of neur...
Enzymes: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1Benzphetamine Dopamine Reuptake Inhibitor Action Pathway
smpdb.ca/view/SMP0126989Drug actionBenzphetamine, commonly known as Didrex, is a sympathomimetic used to treat exogenous obesity. It has properties similar to dextroamphetamine. This drug can be used as a short-term treatment of obesity when combined with altered lifestyl...
Enzymes: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1Vanoxerine Dopamine Reuptake Inhibitor Action Pathway
smpdb.ca/view/SMP0126997Drug actionVanoxerine is an investigational drug that is a selective dopamine transporter antagonist that has not been approved for therapeutic use but is indicated to help treat cocaine addiction. It was developed as a treatment for depression but...
Enzymes: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1Methylphenidate Dopamine Reuptake Inhibitor Action Pathway
smpdb.ca/view/SMP0125204Drug actionMethylphenidate, known commonly as Ritalin, is a central nervous system stimulant used mainly for ADHD, but also for narcolepsy. ADHD is caused by an abnormality in the dopamine transporter gene (DAT1), the D4 receptor gene (DRD-4), and/...
Enzymes: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1Bupropion Action Pathway
smpdb.ca/view/SMP0125268Drug actionBupropion, known as the brand name Wellbutrin, is a norepinephrine/dopamine reuptake inhibitor (NDRI) used most commonly as a treatment for major depressive disorder (MDD), and seasonal affective disorder (SAD). It can also be used as a ...
Enzymes: Guanine nucleotide-binding protein G(s) subunit alpha isoforms shortMazindol Dopamine Reuptake Inhibitor Action Pathway
smpdb.ca/view/SMP0126988Drug actionMazindol, commonly known as Sanorex, is a sympathomimetic used to treat Duchenne muscular dystrophy. It has similar side effects to amphetamine but is less toxic. This drug can be used as a short-term treatment of obesity when combined w...
Enzymes: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1Lisdexamfetamine Dopamine Reuptake Inhibitor Action Pathway
smpdb.ca/view/SMP0126990Drug actionLisdexamfetamine, known commonly as Vyvanse, is a prodrug of amphetamine paired with lysine and used mainly for treating ADHD and binge eating disorders. The drug was engineered to be abuse-resistant with a delayed release. ADHD is cause...
Enzymes: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1