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Cocaine Dopamine-reuptake Inhibitor Action Pathway
smpdb.ca/view/SMP0126543Drug actionCocaine is a local anesthesia and vasoconstrictor that is clinically used during diagnostic proceedures or during surgery in or through the nasal cavity. It comes in drugs called Goprelto and Numbrino which comes as a nasal spray. In the...
Enzymes: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1Benzatropine Dopamine Reuptake Inhibitor Action Pathway
smpdb.ca/view/SMP0126985Drug actionBenzatropine, known commonly as Cogentin, is an anticholinergic drug used to treat Parkinson's disease and extrapyramidal symptoms, except tardive dyskinesia. Benzatropine is used in therapy for parkinsonism, referring to a group of neur...
Enzymes: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1Benzphetamine Dopamine Reuptake Inhibitor Action Pathway
smpdb.ca/view/SMP0126989Drug actionBenzphetamine, commonly known as Didrex, is a sympathomimetic used to treat exogenous obesity. It has properties similar to dextroamphetamine. This drug can be used as a short-term treatment of obesity when combined with altered lifestyl...
Enzymes: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1Vanoxerine Dopamine Reuptake Inhibitor Action Pathway
smpdb.ca/view/SMP0126997Drug actionVanoxerine is an investigational drug that is a selective dopamine transporter antagonist that has not been approved for therapeutic use but is indicated to help treat cocaine addiction. It was developed as a treatment for depression but...
Enzymes: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1Pentoxifylline
go.drugbank.com/drugs/DB00806ApprovedInvestigational[A226608] Pentoxifylline has been marketed in Europe since 1972; PTX extended-release tablets sold under the trade name TRENTAL by US Pharm Holdings were first approved by the FDA on Aug 30, 1984, but … Pentoxifylline (PTX) is a synthetic dimethylxanthine derivative that modulates the rheological properties of blood and also has both anti-oxidant and anti-inflammatory properties.
Mixtures: Betamethasone Dipropionate 0.05% / Minoxidil 5% / Niacinamide 2% / Pentoxifylline 0.5%Categories: Cytochrome P-450 Substrates, Heterocyclic Compounds, 2-RingChikungunya vaccine (live, attenuated)
go.drugbank.com/drugs/DB18701ApprovedInvestigational[A262051] Prior to 2013, chikungunya virus cases and outbreaks had been identified in countries in Africa, Asia, Europe, and the Indian and Pacific Oceans. … Chikungunya virus (CHIKV) is a member of the Alphavirus genus that was first identified in Tanzania in 1952.[A262051] It is spread primarily by the bite of infected mosquitos of the _Aedes_ genus.
Tibolone
go.drugbank.com/drugs/DB09070ApprovedInvestigationalIt has been used in Europe for almost 2 decades, primarily for the prevention of postmenopausal osteoporosis and the treatment of post-menopausal symptoms [L1720]. … Tibolone is a synthetic steroid hormone drug, which is mainly non-selective in its binding profile, acting as an agonist primarily at estrogen receptors (ER), with a preference for ER alpha [L1874].
Synonyms: 17-hydroxy-7alpha-methyl-19-nor-17alpha-pregn-5(10)-en-20-yn-3-oneProducts: HOLIK-B, TINOX®.Nirsevimab
go.drugbank.com/drugs/DB16258ApprovedInvestigational[L44146] It binds to the prefusion conformation of the RSV F protein, a glycoprotein involved in the membrane fusion step of the viral entry process, and neutralizes several RSV A and B strains. … [A254691] This is due to a modification in the Fc region of nirsevimab that grants it a longer half-time compared to typical monoclonal antibodies.
Categories: Respiratory Syncytial Virus Anti-F Protein Monoclonal AntibodySynonyms: Immunoglobulin g1-kappa, anti-(human respiratory syncytial virus fusion glycoprotein f0 (protein f))human monoclonal antibody.gamma.1 heavy chain (1-456) (human vh (homo sapiens ighv1-69*01(ighd)-ighj4, *01 (90.1%)) (8.8.19) (1-126) -homo sapiens ighg1*03Methylphenidate Dopamine Reuptake Inhibitor Action Pathway
smpdb.ca/view/SMP0125204Drug actionMethylphenidate, known commonly as Ritalin, is a central nervous system stimulant used mainly for ADHD, but also for narcolepsy. ADHD is caused by an abnormality in the dopamine transporter gene (DAT1), the D4 receptor gene (DRD-4), and/...
Enzymes: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1Bupropion Action Pathway
smpdb.ca/view/SMP0125268Drug actionBupropion, known as the brand name Wellbutrin, is a norepinephrine/dopamine reuptake inhibitor (NDRI) used most commonly as a treatment for major depressive disorder (MDD), and seasonal affective disorder (SAD). It can also be used as a ...
Enzymes: Guanine nucleotide-binding protein G(s) subunit alpha isoforms short