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Displaying results 111 - 120 of 561 in total
  1. Target

    Protein S100-A8

    go.drugbank.com/bio_entities/BE0008955
    TargetHumans

    S100A8 is a calcium- and zinc-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response. It can induce neutrophil chemotaxis and adhesion.

    Synonyms: S100 calcium-binding protein A8
  2. Target

    Epithelial cell adhesion molecule

    go.drugbank.com/bio_entities/BE0002446
    TargetHumans

    May act as a physical homophilic interaction molecule between intestinal epithelial cells (IECs) and intraepithelial lymphocytes (IELs) at the mucosal epithelium for providing immunological barrier as a first line of defense against muco...

    Synonyms: Tumor-associated calcium signal transducer 1
  3. Target

    Cyclic nucleotide phosphodiesterase

    go.drugbank.com/bio_entities/BE0004922
    TargetHumans

    Calcium/calmodulin-dependent cyclic nucleotide phosphodiesterase with a dual specificity for the second messengers cGMP and cAMP, which are key regulators of many important physiological processes.

    Polypeptides: Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A, Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B
  4. Target

    Peroxiredoxin-6

    go.drugbank.com/bio_entities/BE0004641
    TargetHumans

    Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively (PubMed:10893423, PubMed:9497358). Can reduce H(2)O(2) and short chain organic, fatty acid, and ph...

    Synonyms: Acidic calcium-independent phospholipase A2
  5. Target

    Coagulation factor VII

    go.drugbank.com/bio_entities/BE0000333
    TargetHumans

    Factor VIIa also converts factor IX to factor IXa in the presence of tissue factor and calcium (PubMed:271951) … In the presence of tissue factor and calcium ions, factor VIIa then converts factor X to factor Xa by limited proteolysis.

    Function: calcium ion binding
  6. Target

    Calcineurin subunit B type 1

    go.drugbank.com/bio_entities/BE0000358
    TargetHumans

    Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity

    Function: calcium ion binding
  7. Target

    Glutamate receptor ionotropic, NMDA 3A

    go.drugbank.com/bio_entities/BE0000641
    TargetHumans

    Component of a non-conventional N-methyl-D-aspartate (NMDA) receptors (NMDARs) that function as heterotetrameric, ligand-gated cation channels with low calcium permeability and low voltage-dependent block

    Function: calcium channel activity
  8. Target

    Cubilin

    go.drugbank.com/bio_entities/BE0000936
    TargetTransporterHumans

    Ligand binding requires calcium (PubMed:9572993). Serves as important transporter in several absorptive epithelia, including intestine, renal proximal tubules and embryonic yolk sac.

    Function: calcium ion binding
  9. Target

    Metabotropic glutamate receptor 2

    go.drugbank.com/bio_entities/BE0000974
    TargetHumans

    Upon activation by glutamate, inhibits presynaptic calcium channels, reducing further glutamate release and dampening excitatory signaling (By similarity).

    Function: calcium channel regulator activity
  10. Target

    Calreticulin

    go.drugbank.com/bio_entities/BE0002109
    TargetCarrierHumans

    May participate in oocyte maturation via the regulation of calcium homeostasis (By similarity). … Calcium-binding chaperone that promotes folding, oligomeric assembly and quality control in the endoplasmic reticulum (ER) via the calreticulin/calnexin cycle.

    Function: calcium ion binding