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Tyrosinemia, Transient, of the Newborn
smpdb.ca/view/SMP0125592Diseaseand derivatives. … The inhibition is reversible by removal of excess substrate and by reducing agents such as ascorbic acid, 2, 6-dichiorophenolindophenol, and a number of hydroquinone and phenylenediamine compounds.
Drugs: Pyridoxal phosphate · Ademetionine · Ascorbic acid · Aspartic acid · Tyrosine · Glutamic acid +20 moreDopamine beta-Hydroxylase Deficiency
smpdb.ca/view/SMP0125594DiseaseNoradrenaline and adrenaline are generally not detectable in plasma, urine, and cerebrospinal fluid, but dopamine is increased 7- to 12-fold in plasma, 4-fold in urine, and 20-fold in CSF. … Treatment with dihydroxyphenylserine has been shown to reduce symptoms and signs of postural hypotension and increase plasma levels of noradrenaline.
Drugs: Pyridoxal phosphate · Ademetionine · Ascorbic acid · Aspartic acid · Tyrosine · Glutamic acid +20 moreDroxidopa B1-Adrenergic Cardiac Muscle Contraction Action Pathway
smpdb.ca/view/SMP0126078Drug actionassociated symptoms of lightheadedness, dizziness, blurred vision, and syncope through the induction of tachycardia (increased heart rate) and hypertension. … Some side effects of using droxidopa may include headache, dizziness, nausea, high blood pressure, and fainting.
Imipramine Action Pathway (New)
smpdb.ca/view/SMP0126359Drug action, and hallucinations. … schizophrenia, for the treatment of acute stress disorder and posttraumatic stress disorder, and for symptomatic treatment of postherpetic neuralgia and painful diabetic neuropathy.
Drugs: Pyridoxal phosphate · Ascorbic acid · Tyrosine · Tryptophan · Sapropterin · Norepinephrine +7 moreDesvenlafaxine SNRI - Norepinephrine reuptake Inhibition Action Pathway
smpdb.ca/view/SMP0126425Drug action(ODV) commonly called desvenlafaxine potently and selectively inhibits the reuptake of both serotonin and norepinephrine at the presynaptic terminal. … Venlafaxine and desvenlafaxine are also weak inhibitors of dopamine reuptake.
Drugs: Pyridoxal phosphate · Ascorbic acid · Tyrosine · Venlafaxine · Norepinephrine · Dopamine +6 moreNorepinephrine Beta-1 Adrenergic Cardiac Action Pathway
smpdb.ca/view/SMP0126438Drug actionWhen taken pharmacologically it acts on the sympathetic nervous system in the heart and the blood vessels. It is mainly used pharmacologically for hypotension and vasodilatory shock states. … Myosin, with an ADP and phosphate attached, binds to actin to form a cross bridge. Myosin performs a powerstroke, drawing the actin filaments together.
Pramipexole Mechanism of Action Action Pathway
smpdb.ca/view/SMP0126459Drug actionPramipexole is considered a non-ergot dopamine agonist that shows specificity and strong activity at the D2 subfamily of dopamine receptors in vitro, binding selectively and dopamine D2 receptors and showing … Pramipexole is indicated for the management of Parkinson's disease and symptomatic treatment of moderate to severe primary Restless Legs Syndrome (RLS).
Droxidopa A1-Adrenergic Vasoconstriction Action Pathway
smpdb.ca/view/SMP0126494Drug actionNorephinephrine acts at alpha-adrenergic receptors as a vasoconstrictor and at beta-adrenergic receptors as a heart stimulator and artery dilator. … associated symptoms of lightheadedness, dizziness, blurred vision, and syncope through the induction of tachycardia (increased heart rate) and hypertension.
Isocarboxazid Amine Oxidase Norepinephrine Antidepressant Action Pathway
smpdb.ca/view/SMP0126692Drug actionThe first one is found in cells located in the periphery and breakdown serotonin, norepinephrine, epinephrine, dopamine, and tyramine. … The monoamine oxidase is an enzyme that catalyzes the oxidative deamination of many amines like serotonin, norepinephrine, epinephrine, and dopamine. There are 2 isoforms of this protein: A and B.
Phentermine Norepinephrine Reuptake transporter Satiety Action Pathway
smpdb.ca/view/SMP0126723Drug actionPhentermine inhibits the sodium-dependent noradrenaline transporter, the sodium-dependent serotonin transporter, and the sodium-dependent dopamine transporter. … This drug is administered as an oral capsule.