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Doxorubicin Metabolism Pathway
smpdb.ca/view/SMP0000650Drug metabolismDoxorubicin is an anthracycline antibiotic used as a cancer chemotherapy drug. The major metabolic route of doxorubicin metabolism is two-electron reduction to doxorubicinol. A second route is one-electron reduction resulting in a doxoru...
Tranylcypromine Amine Oxidase Serotonin Antidepressant Action Pathway
smpdb.ca/view/SMP0126744Drug actionTranylcypromine is a non-hydrazine monoamine oxidase inhibitor belonging to the class of antidepressants called MAOIs. This drug is indicated in the treatment of major depression, dysthymic disorder, and atypical depression. It also is u...
Phenelzine Amine Oxidase Serotonin Antidepressant Action Pathway
smpdb.ca/view/SMP0126746Drug actionPhenelzine, also known as Nardil, is a monoamine oxidase inhibitor (MAOIs). This drug is used as an antidepressant and it is also effective in the treatment of panic disorder and social anxiety disorder. The monoamine oxidase is an enzym...
Minaprine Serotonin receptor Antidepressant Action Pathway
smpdb.ca/view/SMP0126747Drug actionMinaprine is an amino-phenylpyridazine antidepressant. It is indicated in the treatment of various depressive states. Minaprine acts on many targets in the neurons. Firstly, this drug binds as an antagonist to the serotonin type 2 recept...
Isocarboxazid Amine Oxidase Serotonin Antidepressant Action Pathway
smpdb.ca/view/SMP0126762Drug actionIsocarboxazid, also known as Marplan, is an antidepressant from the monoamine oxidase inhibitors (MAOIs) drug class. This drug is indicated in different disorders like major depression, dysthymic disorder, atypical disorder, panic disord...
Risperidone Dopamine Antagonist Action Pathway
smpdb.ca/view/SMP0126599Drug actionRisperidone is a second-generation antipsychotic medication used to treat a number of mental health disorders including schizophrenia, bipolar mania, psychosis, or as an adjunct in severe depression. Paliperidone is the primary active me...
Moclobemide Amine Oxidase B Serotonin Antidepressant Action Pathway
smpdb.ca/view/SMP0126754Drug actionMoclobemide is a reversible monoamine oxidase inhibitor (MAOIs) selective for the isoform A (RIMA). This molecule is indicated in the treatment of major depressive disorder (MDD) and bipolar disorder. he monoamine oxidase is an enzyme th...
Pargyline Amine Oxidase Serotonin Antidepressant Action Pathway
smpdb.ca/view/SMP0126766Drug actionPargyline is a monoamine oxidase B inhibitor (MAOI). This drug has antihypertensive properties and is, thus, indicated in treating moderate to severe hypertension. Pargyline inhibits the breakdown of monoamine neurotransmitters, leading ...
Nitric Oxide Signaling Pathway
smpdb.ca/view/SMP0063777SignalingNitric oxide (NO) is a gaseous chemical transmitter that is produced from the amino acid L-arginine by the members of the NO synthase (NOS) family of proteins. The NOS family of enzymes catalyzes the oxidation of L-arginine to form L-cit...
Hyperphenylalaninemia Due to 6-Pyruvoyltetrahydropterin Synthase Deficiency (ptps)
smpdb.ca/view/SMP0125585DiseaseBH4-deficient hyperphenylalaninemia has several causes. One such cause is a PTS deficiency resultant from a genetic mutation. (In particular, a mutation in the gene encoding 6-pyruvoyl-tetrahydropterin synthase.) The mutation is autosoma...