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Displaying results 111 - 120 of 134541 in total
  1. Pathway

    Metabolism and Physiological Effects of N-Acetyl-3-Methylhistidine

    smpdb.ca/view/SMP0126795
    Metabolic

    N-Acetyl-3-methylhistidine, an N-acetyl-L-amino acid, belongs to the class of organic compounds known as histidine and derivatives. … N-Acetyl-3-methylhistidine is an acetylated derivative of 3-methylhistidine and a very strong basic compound (based on its pKa).

    Drugs: Histidine · Ademetionine
  2. Pathway

    Metabolism and Physiological Effects of N-alpha-Acetyl-L-arginine

    smpdb.ca/view/SMP0125530
    Metabolic

    Arginnosuccinate is synthesized from citrulline and aspartic acid by the enzyme argininosuccinate synthase. That is catalyzed by argininosuccinate lyase to produce arginine and fumaric acid. … In the blood it works as a uremic toxin to cause kidney damage, cardiovascular disease and neurological deficits.

    Drugs: Pyridoxal phosphate · Arginine · Aspartic acid · Ornithine · L-Glutamine · Adenosine phosphate +10 more
  3. Pathway

    Ziconotide NMDA and Substance P Receptor Pain Inhibition Action Pathway

    smpdb.ca/view/SMP0126347
    Drug action

    such as intrathecal morphine and systemic analgesics. … This causes downstream nociceptive neuronal activity and pain perception. Substance P and CGRP both also induce inflammation, further exasperating chronic pain.

    Drugs: Glutamic acid · Calcium · Sar9, Met (O2)11-Substance P · Ziconotide
  4. Pathway

    Icosapent Prostaglandin G/H synthase 1 and 2 anti-inflammatory Action Pathway

    smpdb.ca/view/SMP0126557
    Drug action

    This molecule also inhibits the arachidonic acid conversion into the thromboxane-2 and prostaglandin-2 families because it inhibits the prostaglandin G/H synthase 1 and 2 (COX-1 and COX-2). … Then icosapent shows anti-atherogenic and anti-thrombotic effects in cells. EPA serves as a substrate for Prostaglandin-endoperoxide synthase 1 and 2.

    Drugs: Glutathione · Icosapent · Dinoprostone · Calcium · Mesoheme · Prostaglandin G2 +1 more
  5. Pathway

    Fish oil Prostaglandin G/H synthase 1 and 2 anti-inflammatory Action Pathway

    smpdb.ca/view/SMP0126563
    Drug action

    EPA and DHA do competition with arachidonic acids for both COX-1 and COX-2 enzymes. … These are responsible for the conversion of arachidonic acid (an omega-6 fatty acid) into prostaglandins and thromboxanes, which are important mediators of inflammation and pain.

    Drugs: Glutathione · Icosapent · Dinoprostone · Calcium · Mesoheme · Prostaglandin G2 +1 more
  6. Pathway

    Ferric pyrophosphate citrate Drug Metabolism

    smpdb.ca/view/SMP0130618
    Metabolic

    Ferric pyrophosphate citrate passes through the liver and is then excreted from the body mainly through the kidney. … Ferric pyrophosphate citrate is a drug that is not metabolized by the human body as determined by current research and biotransformer analysis.

    Drugs: Ferric pyrophosphate citrate
  7. Pathway

    Diazoxide Drug Metabolism

    smpdb.ca/view/SMP0130712
    Metabolic

    Diazoxide passes through the liver and is then excreted from the body mainly through the kidney. … Diazoxide is a drug that is not metabolized by the human body as determined by current research and biotransformer analysis.

    Drugs: Diazoxide
  8. Pathway

    Finerenone Action Pathway

    smpdb.ca/view/SMP0126009
    Drug action

    In the principal cells of the collecting duct, sodium and water reabsorption occur, along with potassium excretion. … This effect on gene transcription leads to an upregulation of sodium channels in the apical membrane and Na+/K+ ATPase in the basolateral membrane, aiding an increase in Na+ and water reabsorption and

    Drugs: Potassium cation · Urea · Finerenone
    Enzymes: Sodium/potassium-transporting ATPase subunit alpha-1, Sodium/potassium-transporting ATPase subunit beta-1
  9. Pathway

    Triamterene Action Pathway (New)

    smpdb.ca/view/SMP0126281
    Drug action

    sodium uptake and potassium secretion. … In the late distal tubule to the collecting duct, sodium ions are actively reabsorbed via ENaC on the luminal membrane and are extruded out of the cell into the peritubular medium by a sodium-potassium

    Drugs: Triamterene · Potassium cation · Urea
    Enzymes: Sodium/potassium-transporting ATPase subunit alpha-1, Sodium/potassium-transporting ATPase subunit beta-1
  10. Pathway

    Amiloride Action Pathway (New)

    smpdb.ca/view/SMP0126243
    Drug action

    This promotes the loss of sodium and water from the body, but without depleting potassium. … Amiloride is a pyrizine compound used to treat hypertension and congestive heart failure.It is a pyrazine compound inhibiting sodium reabsorption through sodium channels in renal epithelial cells.

    Drugs: Amiloride · Potassium cation · Urea
    Enzymes: Sodium/potassium-transporting ATPase subunit alpha-1, Sodium/potassium-transporting ATPase subunit beta-1