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Miltefosine
go.drugbank.com/drugs/DB09031ApprovedInvestigationalThe CDC has also recommended it as a first line treatment for free-living amebae (FLA) infections such as primary amebic meningoencephalitis and granulomatous amebic encephalitis.
Zotepine
go.drugbank.com/drugs/DB09225ApprovedWithdrawn[A31857] Zotepine was never approved by the FDA. … [L1082] When the analysis of antipsychotics was retaken in 2016 by the FDA, zotepine did not reach the threshold effect to be further studied.[L1313].
Categories: Dopamine D2 Receptor Antagonists, Serotonin Receptor AntagonistsTransient receptor potential cation channel subfamily A member 1
go.drugbank.com/bio_entities/BE0001122TargetHumansAlso acts as an ionotropic cannabinoid receptor by being activated by delta(9)-tetrahydrocannabinol (THC), the psychoactive component of marijuana (PubMed:25389312).
Polypeptides: Transient receptor potential cation channel subfamily A member 1Synonyms: Wasabi receptorTransient receptor potential cation channel subfamily M member 8
go.drugbank.com/bio_entities/BE0001186TargetHumansNon-selective ion channel permeable to monovalent and divalent cations, including Na(+), K(+), and Ca(2+), with higher permeability for Ca(2+). Activated by multiple factors, such as temperature, voltage, pressure, and changes in osmolal...
Polypeptides: Transient receptor potential cation channel subfamily M member 8Synonyms: Transient receptor potential p8, Long transient receptor potential channel 6Low affinity immunoglobulin gamma Fc region receptor III-A
go.drugbank.com/bio_entities/BE0002097TargetHumansReceptor for the invariable Fc fragment of immunoglobulin gamma (IgG). … The ITAM-dependent signaling coupled to receptor phosphorylation by PKC mediates robust intracellular calcium flux that leads to production of pro-inflammatory cytokines, whereas in the absence of receptor
Polypeptides: Low affinity immunoglobulin gamma Fc region receptor III-ASynonyms: IgG Fc receptor III-2, IgG Fc receptor III-ALow affinity immunoglobulin gamma Fc region receptor II-c
go.drugbank.com/bio_entities/BE0002100TargetHumansReceptor for the Fc region of complexed immunoglobulins gamma. Low affinity receptor.
Polypeptides: Low affinity immunoglobulin gamma Fc region receptor II-cSynonyms: IgG Fc receptor II-cTransient receptor potential cation channel subfamily V member 3
go.drugbank.com/bio_entities/BE0003416TargetHumansNon-selective calcium permeant cation channel (PubMed:12077604, PubMed:12077606, PubMed:26818531, PubMed:37648856, PubMed:38691614). It is activated by innocuous (warm) temperatures and shows an increased response at noxious temperatures...
Polypeptides: Transient receptor potential cation channel subfamily V member 3Synonyms: Vanilloid receptor-like 3Transient receptor potential cation channel subfamily M member 7
go.drugbank.com/bio_entities/BE0004624TargetTransporterHumansBifunctional protein that combines an ion channel with an intrinsic kinase domain, enabling it to modulate cellular functions either by conducting ions through the pore or by phosphorylating downstream proteins via its kinase domain. The...
Polypeptides: Transient receptor potential cation channel subfamily M member 7Synonyms: Long transient receptor potential channel 7Transient receptor potential cation channel subfamily V member 5
go.drugbank.com/bio_entities/BE0005112TransporterHumansConstitutively active calcium selective cation channel thought to be involved in Ca(2+) reabsorption in kidney and intestine (PubMed:11549322, PubMed:18768590). Required for normal Ca(2+) reabsorption in the kidney distal convoluted tubu...
Polypeptides: Transient receptor potential cation channel subfamily V member 5Transient receptor potential cation channel subfamily M member 6
go.drugbank.com/bio_entities/BE0005126TransporterHumansBifunctional protein that combines an ion channel with an intrinsic kinase domain, enabling it to modulate cellular functions either by conducting ions through the pore or by phosphorylating downstream proteins via its kinase domain (Pub...
Polypeptides: Transient receptor potential cation channel subfamily M member 6