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Displaying results 1261 - 1270 of 1993 in total
  1. Target

    Tumor necrosis factor receptor superfamily member 1A

    go.drugbank.com/bio_entities/BE0001139
    TargetHumans

    Receptor for TNFSF2/TNF and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor.

    Polypeptides: Tumor necrosis factor receptor superfamily member 1ASynonyms: Tumor necrosis factor receptor 1, Tumor necrosis factor receptor type I
  2. Target

    Triggering receptor expressed on myeloid cells 1

    go.drugbank.com/bio_entities/BE0001288
    TargetHumans

    By also promoting the amplification of inflammatory signals that are initially triggered by Toll-like receptor (TLR) and NOD-like receptor engagement, plays a major role in the pathophysiology of acute … Cell surface receptor that plays important roles in innate and adaptive immunity by amplifying inflammatory responses (PubMed:10799849, PubMed:21393102).

    Polypeptides: Triggering receptor expressed on myeloid cells 1Synonyms: Triggering receptor expressed on monocytes 1
  3. Target

    Gamma-aminobutyric acid receptor subunit beta-1

    go.drugbank.com/bio_entities/BE0002344
    TargetHumans

    Beta subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain (PubMed:10449790, PubMed:16412217, PubMed:26950270). GABA-gated chloride channel...

    Polypeptides: Gamma-aminobutyric acid receptor subunit beta-1Synonyms: GABA(A) receptor subunit beta-1
  4. Target

    Gamma-aminobutyric acid receptor subunit beta-2

    go.drugbank.com/bio_entities/BE0002346
    TargetHumans

    Beta subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain (PubMed:19763268, PubMed:27789573, PubMed:29950725, PubMed:8264558). GABA-gated ...

    Polypeptides: Gamma-aminobutyric acid receptor subunit beta-2Synonyms: GABA(A) receptor subunit beta-2
  5. Target

    Tumor necrosis factor receptor superfamily member 11A

    go.drugbank.com/bio_entities/BE0003461
    TargetHumans

    Receptor for TNFSF11/RANKL/TRANCE/OPGL; essential for RANKL-mediated osteoclastogenesis (PubMed:9878548).

    Polypeptides: Tumor necrosis factor receptor superfamily member 11ASynonyms: Receptor activator of NF-KB, Osteoclast differentiation factor receptor
  6. Target

    C-X-C chemokine receptor type 1

    go.drugbank.com/bio_entities/BE0003552
    TargetHumans

    Receptor to interleukin-8, which is a powerful neutrophils chemotactic factor (PubMed:1840701). Binding of IL-8 to the receptor causes activation of neutrophils.

    Polypeptides: C-X-C chemokine receptor type 1Synonyms: IL-8 receptor type 1, High affinity interleukin-8 receptor A
  7. Target

    Gamma-aminobutyric acid receptor subunit gamma-2

    go.drugbank.com/bio_entities/BE0003592
    TargetHumans

    GABAARs function also as histamine receptor where histamine binds at the interface of two neighboring beta subunits and potentiates GABA response in a gamma-2 subunit-controlled manner (By similarity)

    Polypeptides: Gamma-aminobutyric acid receptor subunit gamma-2Synonyms: GABA(A) receptor subunit gamma-2
  8. Target

    Gamma-aminobutyric acid receptor subunit rho-2

    go.drugbank.com/bio_entities/BE0003598
    TargetHumans

    Rho subunit of the pentameric ligand-gated chloride channels responsible for mediating the effects of gamma-aminobutyric acid (GABA), the major inhibitory neurotransmitter in the brain (By similarity). Rho-containing GABA-gated chloride ...

    Polypeptides: Gamma-aminobutyric acid receptor subunit rho-2Synonyms: GABA(C) receptor, GABA(A) receptor subunit rho-2
  9. Target

    Acetylcholine receptor subunit beta-type unc-29

    go.drugbank.com/bio_entities/BE0004928
    TargetCaenorhabditis elegans

    Non-alpha subunit of nicotinic acetylcholine receptor (nAChR). Involved in nAChR sensitivity to nicotine and levasimole.

    Polypeptides: Acetylcholine receptor subunit beta-type unc-29
  10. Target

    Receptor-interacting serine/threonine-protein kinase 2

    go.drugbank.com/bio_entities/BE0009532
    TargetHumans

    Also involved in adaptive immunity: plays a role during engagement of the T-cell receptor (TCR) in promoting BCL10 phosphorylation and subsequent NF-kappa-B activation (PubMed:14638696). … Once recruited, RIPK2 autophosphorylates and undergoes 'Lys-63'-linked polyubiquitination by E3 ubiquitin ligases XIAP, BIRC2 and BIRC3, as well as 'Met-1'-linked (linear) polyubiquitination by the LUBAC

    Polypeptides: Receptor-interacting serine/threonine-protein kinase 2Synonyms: Receptor-interacting protein 2