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Displaying results 1271 - 1280 of 3735 in total
  1. Target

    Low affinity immunoglobulin gamma Fc region receptor III-A

    go.drugbank.com/bio_entities/BE0002097
    TargetHumans

    Receptor for the invariable Fc fragment of immunoglobulin gamma (IgG). … The ITAM-dependent signaling coupled to receptor phosphorylation by PKC mediates robust intracellular calcium flux that leads to production of pro-inflammatory cytokines, whereas in the absence of receptor

    Polypeptides: Low affinity immunoglobulin gamma Fc region receptor III-ASynonyms: IgG Fc receptor III-2, IgG Fc receptor III-A
  2. Target

    Low affinity immunoglobulin gamma Fc region receptor II-c

    go.drugbank.com/bio_entities/BE0002100
    TargetHumans

    Receptor for the Fc region of complexed immunoglobulins gamma. Low affinity receptor.

    Polypeptides: Low affinity immunoglobulin gamma Fc region receptor II-cSynonyms: IgG Fc receptor II-c
  3. Target

    Transient receptor potential cation channel subfamily V member 3

    go.drugbank.com/bio_entities/BE0003416
    TargetHumans

    Non-selective calcium permeant cation channel (PubMed:12077604, PubMed:12077606, PubMed:26818531, PubMed:37648856, PubMed:38691614). It is activated by innocuous (warm) temperatures and shows an increased response at noxious temperatures...

    Polypeptides: Transient receptor potential cation channel subfamily V member 3Synonyms: Vanilloid receptor-like 3
  4. Target

    Transient receptor potential cation channel subfamily M member 7

    go.drugbank.com/bio_entities/BE0004624
    TargetTransporterHumans

    Bifunctional protein that combines an ion channel with an intrinsic kinase domain, enabling it to modulate cellular functions either by conducting ions through the pore or by phosphorylating downstream proteins via

    Polypeptides: Transient receptor potential cation channel subfamily M member 7Synonyms: Long transient receptor potential channel 7
  5. Target

    Transient receptor potential cation channel subfamily V member 5

    go.drugbank.com/bio_entities/BE0005112
    TransporterHumans

    Constitutively active calcium selective cation channel thought to be involved in Ca(2+) reabsorption in kidney and intestine (PubMed:11549322, PubMed:18768590). Required for normal Ca(2+) reabsorption in the kidney distal convoluted tubu...

    Polypeptides: Transient receptor potential cation channel subfamily V member 5
  6. Target

    Transient receptor potential cation channel subfamily M member 6

    go.drugbank.com/bio_entities/BE0005126
    TransporterHumans

    Bifunctional protein that combines an ion channel with an intrinsic kinase domain, enabling it to modulate cellular functions either by conducting ions through the pore or by phosphorylating downstream proteins via

    Polypeptides: Transient receptor potential cation channel subfamily M member 6
  7. Target

    Transient receptor potential cation channel subfamily V member 4

    go.drugbank.com/bio_entities/BE0009159
    TargetHumans

    Non-selective calcium permeant cation channel involved in osmotic sensitivity and mechanosensitivity (PubMed:16293632, PubMed:18695040, PubMed:18826956, PubMed:22526352, PubMed:23136043, PubMed:29899501). Activation by exposure to hypoto...

    Polypeptides: Transient receptor potential cation channel subfamily V member 4Synonyms: Vanilloid receptor-like channel 2, Vanilloid receptor-like protein 2
  8. Target

    B-cell antigen receptor complex-associated protein beta chain

    go.drugbank.com/bio_entities/BE0009680
    TargetHumans

    Required in cooperation with CD79A for initiation of the signal transduction cascade activated by the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to

    Polypeptides: B-cell antigen receptor complex-associated protein beta chain
  9. Target

    Transient receptor potential cation channel subfamily M member 4

    go.drugbank.com/bio_entities/BE0009748
    TargetHumans

    Calcium-activated selective cation channel that mediates membrane depolarization (PubMed:12015988, PubMed:12842017, PubMed:29211723, PubMed:30528822). While it is activated by increase in intracellular Ca(2+), it is impermeable to it (Pu...

    Polypeptides: Transient receptor potential cation channel subfamily M member 4Synonyms: Long transient receptor potential channel 4
  10. Drug

    Miricorilant

    go.drugbank.com/drugs/DB16234
    Investigational

    Miricorilant is under investigation in clinical trial NCT03818256 (Study Evaluating the Safety, Efficacy, and Pharmacokinetics of Miricorilant (CORT118335) in Obese Adult Patients With Schizophrenia and Recent

    Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2C19 Substrates