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Displaying results 121 - 130 of 509 in total
  1. Target

    Sodium/myo-inositol cotransporter 2

    go.drugbank.com/bio_entities/BE0017647
    TransporterHumans

    Exhibits stereospecific cotransport of both D-glucose and D-xylose (By similarity). May induce apoptosis through the TNF, PDCD1 pathway (PubMed:15172003, PubMed:18069935). … Exclusively responsible for apical MI transport and absorption in intestine (By similarity). Can also transport D-chiro-inositol (DCI) but not L-fucose (PubMed:15172003, PubMed:19032932).

    Polypeptides: Sodium/myo-inositol cotransporter 2Synonyms: Sodium/glucose cotransporter KST1, Sodium/myo-inositol transporter 2
  2. Target

    Epithelial sodium channel subunit alpha

    go.drugbank.com/bio_entities/BE0000190
    TargetTransporterHumans

    This is one of the three pore-forming subunits of the heterotrimeric epithelial sodium channel (ENaC), a critical regulator of sodium balance and fluid homeostasis (PubMed:30251954, PubMed:32729833, PubMed … It plays a key role in maintaining sodium homeostasis through electrogenic sodium reabsorption in the kidneys (PubMed:12107247).

    Polypeptides: Epithelial sodium channel subunit alphaSynonyms: Sodium channel epithelial 1 subunit alpha, Amiloride-sensitive sodium channel subunit alpha
  3. Target

    Epithelial sodium channel subunit gamma

    go.drugbank.com/bio_entities/BE0000497
    TargetTransporterHumans

    This is one of the three pore-forming subunits of the heterotrimeric epithelial sodium channel (ENaC), a critical regulator of sodium balance and fluid homeostasis (PubMed:30251954, PubMed:32729833, PubMed … It plays a key role in maintaining sodium homeostasis through electrogenic sodium reabsorption in the kidneys (PubMed:12107247, PubMed:7550319, PubMed:8640238).

    Polypeptides: Epithelial sodium channel subunit gammaSynonyms: Sodium channel epithelial 1 subunit gamma, Amiloride-sensitive sodium channel subunit gamma
  4. Target

    Ileal sodium/bile acid cotransporter

    go.drugbank.com/bio_entities/BE0003643
    TransporterTargetHumans

    Transports various bile acids, unconjugated or conjugated, such as cholate and taurocholate (PubMed:7592981, PubMed:9458785, PubMed:9856990). … Works collaboratively with the Na(+)-taurocholate cotransporting polypeptide (NTCP), the organic solute transporter (OST), and the bile salt export pump (BSEP), to ensure efficacious biological recycling

    Polypeptides: Ileal sodium/bile acid cotransporterSynonyms: Apical sodium-dependent bile acid transporter, Ileal sodium-dependent bile acid transporter
  5. Target

    Electrogenic sodium bicarbonate cotransporter 1

    go.drugbank.com/bio_entities/BE0004675
    TransporterTargetHumans

    May regulate bicarbonate influx/efflux at the basolateral membrane of cells and regulate intracellular pH … Electrogenic sodium/bicarbonate cotransporter with a Na(+):HCO3(-) stoichiometry varying from 1:2 to 1:3.

    Polypeptides: Electrogenic sodium bicarbonate cotransporter 1Synonyms: Sodium bicarbonate cotransporter
  6. Target

    Electrogenic sodium bicarbonate cotransporter 4

    go.drugbank.com/bio_entities/BE0004677
    TransporterHumans

    Mediates sodium- and bicarbonate-dependent electrogenic sodium bicarbonate cotransport, with a Na(+):HCO3(-) stoichiometry varying from 1:2 to 1:3

    Polypeptides: Electrogenic sodium bicarbonate cotransporter 4
  7. Target

    Electroneutral sodium bicarbonate exchanger 1

    go.drugbank.com/bio_entities/BE0004680
    TransporterTargetHumans

    Mediates electroneutral sodium- and carbonate-dependent chloride-HCO3(-) exchange with a Na(+):HCO3(-) stoichiometry of 2:1 (PubMed:18577713). … Mediates sodium reabsorption in the renal cortical collecting ducts (By similarity)

    Polypeptides: Electroneutral sodium bicarbonate exchanger 1
  8. Target

    Sodium-dependent lysophosphatidylcholine symporter 1

    go.drugbank.com/bio_entities/BE0016969
    TransporterHumans

    Sodium-dependent lysophosphatidylcholine (LPC) symporter, which plays an essential role for blood-brain barrier formation and function (PubMed:24828040, PubMed:32572202, PubMed:34135507). … Transport of LPC is essential because it constitutes the major mechanism by which docosahexaenoic acid (DHA), an omega-3 fatty acid that is essential for normal brain growth and cognitive function, enters

    Polypeptides: Sodium-dependent lysophosphatidylcholine symporter 1Synonyms: Sodium-dependent LPC symporter 1
  9. Target

    MAP kinase-activated protein kinase 3

    go.drugbank.com/bio_entities/BE0004064
    TargetHumans

    Following stress, it is phosphorylated and activated by MAP kinase p38-alpha/MAPK14, leading to phosphorylation of substrates. … Stress-activated serine/threonine-protein kinase involved in cytokines production, endocytosis, cell migration, chromatin remodeling and transcriptional regulation.

    Polypeptides: MAP kinase-activated protein kinase 3Synonyms: MAPK-activated protein kinase 3
  10. Target

    Mitogen-activated protein kinase kinase (MAPKK)

    go.drugbank.com/bio_entities/BE0010124
    TargetHumans

    Binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation. … With MAP2K7/MKK7, is the one of the only known kinase to directly activate the stress-activated protein kinase/c-Jun N-terminal kinases MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3.

    Polypeptides: Dual specificity mitogen-activated protein kinase kinase 1, Dual specificity mitogen-activated protein kinase kinase 2Synonyms: Stress-activated protein kinase kinase 2, Stress-activated protein kinase kinase 1