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Valproic Acid Metabolism Pathway
smpdb.ca/view/SMP0000635Drug metabolismValproic acid (VPA) is metabolized almost entirely in the liver, via at least there routes: glucuronidation, beta oxidation in the mitochondria, and cytochrome P450 mediated oxidation. … The key CYP-mediated reaction of the VPA metabolic pathway is the generation of 4-ene-VPA by CYP2C9, CYP2A6 and CYP2B6. These three enzymes also catalyze the formation of 4-OH-VPA and 5-OH-VPA.
Tiaprofenic Acid Action Pathway
smpdb.ca/view/SMP0000705Drug actionProstaglandin G/H synthase 1 and 2 catalyze the arachidonic acid to prostaglandin G2, and also catalyze prostaglandin G2 to prostaglandin H2 in the metabolism pathway. … Tiaprofenic Acid (also named tiaprofensaeure and surgam) is a nonsteroidal anti-inflammatory drug (NSAID). It can be used to treat pain (especially arthritic pain).
Lysophosphatidic Acid LPA2 Signalling
smpdb.ca/view/SMP0063753SignalingLysophosphatidic acid (LPA) is a water-soluble phospholipid derivative and a potent signalling molecule that binds to six known lysophosphatidic acid receptors (LPARs), named LPA1-LPA6. … LPC, LPE, LPS) into LPA via autotaxin (ATX/Enpp2) and (2) the conversion of phosphatidic acid (PA) into LPA via phospholipase A1 or A2 (PLA1/PLA2).
Enzymes: Lysophosphatidic acid receptor 2Lysophosphatidic Acid LPA4 Signalling
smpdb.ca/view/SMP0063756SignalingLysophosphatidic acid (LPA) is a water-soluble phospholipid derivative and a potent signalling molecule that binds to six known lysophosphatidic acid receptors (LPARs), named LPA1-LPA6. … LPC, LPE, LPS) into LPA via autotaxin (ATX/Enpp2) and (2) the conversion of phosphatidic acid (PA) into LPA via phospholipase A1 or A2 (PLA1/PLA2).
Enzymes: Lysophosphatidic acid receptor 4Mycophenolic Acid Action Pathway
smpdb.ca/view/SMP0122722Drug actionMycophenolic acid is a selective, reversible and potent inhibitor of the enzyme. … Mycophenolic acid is an immunosuppressant drug and anti-proliferative drug derived from Penicillium stoloniferum.
Drugs: Tetrahydrofolic acid · Aspartic acid · L-Glutamine · Adenosine phosphate · Glutamic acid · Glycine +14 moreMeclofenamic acid Action Pathway
smpdb.ca/view/SMP0126104Drug actionMeclofenamic acid is administered as an oral capsule. … Meclofenamic acid inhibits the action of COX-1 and COX-2 on the endoplasmic reticulum membrane. This reduces the formation of prostaglandin H2 and therefore, prostaglandin E2 (PGE2).
Drugs: Glutathione · Dinoprostone · Meclofenamic acid · Calcium · Mesoheme · Prostaglandin G2 +1 moreGlycolic acid Drug Metabolism
smpdb.ca/view/SMP0130509MetabolicGlycolic acid passes through the liver and is then excreted from the body mainly through the kidney. … Glycolic acid is a drug that is not metabolized by the human body as determined by current research and biotransformer analysis.
Drugs: Glycolic acidClodronic acid Drug Metabolism
smpdb.ca/view/SMP0130640MetabolicClodronic acid passes through the liver and is then excreted from the body mainly through the kidney. … Clodronic acid is a drug that is not metabolized by the human body as determined by current research and biotransformer analysis.
Drugs: Clodronic acidHyaluronic acid Drug Metabolism
smpdb.ca/view/SMP0130655MetabolicHyaluronic acid passes through the liver and is then excreted from the body mainly through the kidney. … Hyaluronic acid is a drug that is not metabolized by the human body as determined by current research and biotransformer analysis.
Drugs: Hyaluronic acidIndigotindisulfonic acid Drug Metabolism
smpdb.ca/view/SMP0130815MetabolicIndigotindisulfonic acid passes through the liver and is then excreted from the body mainly through the kidney. … Indigotindisulfonic acid is a drug that is not metabolized by the human body as determined by current research and biotransformer analysis.
Drugs: Indigotindisulfonic acid