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Cytohesin-3
go.drugbank.com/bio_entities/BE0004433TargetHumansPromotes guanine-nucleotide exchange on ARF1 and ARF6. Promotes the activation of ARF factors through replacement of GDP with GTP. Plays a role in the epithelial polarization (By similarity)
Synonyms: PH, SEC7 and coiled-coil domain-containing protein 3Anoctamin-1
go.drugbank.com/bio_entities/BE0004746TargetHumansActs as a major contributor to basal and stimulated chloride conductance in airway epithelial cells and plays an important role in tracheal cartilage development. … Contributes to airway mucus expression induced by interleukins IL3 and IL8 and by the asthma-associated protein CLCA1 and is required for expression of mucin MUC5AC (PubMed:33026825).
Synonyms: Tumor-amplified and overexpressed sequence 2Metal cation symporter ZIP14
go.drugbank.com/bio_entities/BE0009903TransporterHumansMay also function intracellularly and mediate the transport from endosomes to cytosol of iron endocytosed by transferrin (PubMed:20682781). … Controls the cellular uptake by the intestinal epithelium of systemic zinc, which is in turn required to maintain tight junctions and the intestinal permeability (By similarity).
Synonyms: Zrt- and Irt-like protein 14Mitogen-activated protein kinase kinase kinase 20
go.drugbank.com/bio_entities/BE0005595TargetHumansActs by catalyzing phosphorylation of MAP kinase kinases, leading to activation of the JNK (MAPK8/JNK1, MAPK9/JNK2 and/or MAPK10/JNK3) and MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) pathways … Stress-activated component of a protein kinase signal transduction cascade that promotes programmed cell death in response to various stress, such as ribosomal stress, osmotic shock and ionizing radiation
Synonyms: Leucine zipper- and sterile alpha motif-containing kinase, Sterile alpha motif- and leucine zipper-containing kinase AZKSWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4
go.drugbank.com/bio_entities/BE0010396TargetHumansBinds via DLX1 to enhancers located in the intergenic region between DLX5 and DLX6 and this binding is stabilized by the long non-coding RNA (lncRNA) Evf2 (By similarity). … The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves the release of HDAC1 and recruitment of CREBBP (By similarity).
Synonyms: Mitotic growth and transcription activatorGlutamate decarboxylase
go.drugbank.com/bio_entities/BE0010293TargetHumansCatalyzes the synthesis of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA) with pyridoxal 5'-phosphate as cofactor.
Synonyms: Glutamate decarboxylase 2 (Pancreatic islets and brain, 65kDa), Glutamate decarboxylase 2 (Pancreatic islets and brain, 65kDa), isoform CRA_bSerine/threonine-protein kinase DCLK2
go.drugbank.com/bio_entities/BE0009430TargetHumansProtein kinase with a significantly reduced C(a2+)/CAM affinity and dependence compared to other members of the CaMK family. … May play a role in the down-regulation of CRE-dependent gene activation probably by phosphorylation of the CREB coactivator CRTC2/TORC2 and the resulting retention of TORC2 in the cytoplasm (By similarity
Synonyms: Doublecortin-like and CAM kinase-like 2E3 ubiquitin ligase TRAF3IP2
go.drugbank.com/bio_entities/BE0011632TargetHumansUpon IL17A stimulation, interacts with IL17RA and IL17RC receptor chains through SEFIR domains and catalyzes 'Lys-63'-linked polyubiquitination of TRAF6, leading to TRAF6-mediated activation of NF-kappa-B … and MAPkinase pathways (PubMed:19825828)
Synonyms: Connection to IKK and SAPK/JNKHepatitis A virus cellular receptor 2
go.drugbank.com/bio_entities/BE0010551TargetHumansCell surface receptor implicated in modulating innate and adaptive immune responses. Generally accepted to have an inhibiting function. … Expressed on natural killer (NK) cells and acts as a coreceptor to enhance IFN-gamma production in response to LGALS9 (PubMed:22323453).
Synonyms: T-cell immunoglobulin and mucin domain-containing protein 3Tumor necrosis factor ligand superfamily member 13B
go.drugbank.com/bio_entities/BE0000999TargetHumansCytokine that binds to TNFRSF13B/TACI and TNFRSF17/BCMA. TNFSF13/APRIL binds to the same 2 receptors. … Together, they form a 2 ligands -2 receptors pathway involved in the stimulation of B- and T-cell function and the regulation of humoral immunity.
Synonyms: TNF- and APOL-related leukocyte expressed ligand 1