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Thiothixene Dopamine Antagonist Action Pathway
smpdb.ca/view/SMP0126580Drug actionThiothixene is an antipsychotic of the thioxanthene series. Thiothixene acts as an antagonist (blocking agent) on different post-sysnaptic receptors -on dopaminergic-receptors (subtypes D1, D2, D3 and D4 - different antipsychotic propert...
Enzymes: Sodium-dependent dopamine transporterAmitriptyline Serotonin Antagonist Action Pathway
smpdb.ca/view/SMP0126617Drug actionAmitriptyline is a tricyclic antidepressant indicated in the treatment of depressive illness, either endogenous or psychotic, and to relieve depression associated anxiety. The non-FDA-approved indications are anxiety, post-traumatic stre...
Enzymes: Sodium-dependent serotonin transporterPipotiazine Dopamine Antagonist Action Pathway
smpdb.ca/view/SMP0126810Drug actionPipotiazine acts as an antagonist (blocking agent) on different postsysnaptic receptors -on dopaminergic-receptors (subtypes D1, D2, D3 and D4 - different antipsychotic properties on productive and unproductive symptoms), on serotonergic...
Enzymes: Sodium-dependent dopamine transporterThiethylperazine Serotonin Antagonist Action Pathway
smpdb.ca/view/SMP0126477Drug actionThiethylperazine is in the class of the piperazine - phenothiazines which are a class of first generation antipsychotic medications. Phenothiazines are generally dopamine receptor antagonists. Thiethylperazine' s antipsychotic effect is ...
Enzymes: Sodium-dependent serotonin transporterLisuride Dopamine Agonist Action Pathway
smpdb.ca/view/SMP0126654Drug actionLisuride is an anti-Parkinson drug chemically related to the dopaminergic ergoline Parkinson's drugs. Lisuride binds to the 5-HT(1A) and 5-HT(2A/2C) receptors. Lisuride is an ergot derivative that acts as an agonist at dopamine D2 recept...
Enzymes: Sodium-dependent dopamine transporterVortioxetine Serotonin Action Action Pathway
smpdb.ca/view/SMP0126788Drug actionVortioxetine is classified as a serotonin modulator and simulator (SMS) as it has a multimodal mechanism of action towards the serotonin neurotransmitter system whereby it simultaneously modulates one or more serotonin receptors and inhi...
Enzymes: Sodium-dependent serotonin transporterMesoridazine Dopamine Antagonist Action Pathway
smpdb.ca/view/SMP0126523Drug actionMesoridazine, the besylate salt of a metabolite of thioridazine, is a phenothiazine tranquilizer and a first generation typical antipsychotic. Based upon animal studies, mesoridazine, as with other phenothiazines, acts indirectly on reti...
Enzymes: Sodium-dependent dopamine transporterRisperidone Serotonin Antagonist Action Pathway
smpdb.ca/view/SMP0126598Drug actionRisperidone is a second-generation antipsychotic medication used to treat a number of mental health disorders including schizophrenia, bipolar mania, psychosis, or as an adjunct in severe depression. Paliperidone is the primary active me...
Drugs: Pyridoxal phosphate · Tryptophan · Sapropterin · Risperidone · Paliperidone · Calcium +3 moreEnzymes: Sodium-dependent serotonin transporterQuetiapine Dopamine Antagonist Action Pathway
smpdb.ca/view/SMP0126827Drug actionQuetiapine is used in the symptomatic treatment of schizophrenia. In addition, it may be used for the management of acute manic or mixed episodes in patients with bipolar I disorder, as a monotherapy or combined with other drugs. It may ...
Enzymes: Sodium-dependent dopamine transporterModafinil Action Pathway
smpdb.ca/view/SMP0125075Drug actionModafinil is a non-amphetamine central nervous system (CNS) stimulant used to improve wakefulness in patients with sleep apnea, narcolepsy, or shift work disorder. The exact mechanism of action is unclear, although in vitro studies have ...
Enzymes: Sodium-dependent dopamine transporter