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Signal transducer and activator of transcription 5B
go.drugbank.com/bio_entities/BE0000891TargetHumansSignal transducer and transcription activator that mediates cellular responses to cytokines, hormones and growth factors (PubMed:29844444, PubMed:9188471). … Binds to the GAS element and activates PRL-induced transcription. Positively regulates hematopoietic/erythroid differentiation.
Polypeptides: Signal transducer and activator of transcription 5BDisintegrin and metalloproteinase domain-containing protein 10
go.drugbank.com/bio_entities/BE0002404TargetHumansAssociates with six members of the tetraspanin superfamily TspanC8 which regulate its exit from the endoplasmic reticulum and its substrate selectivity (PubMed:26686862, PubMed:28600292, PubMed:31792032 … Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface (PubMed:20592283).
Polypeptides: Disintegrin and metalloproteinase domain-containing protein 10Disintegrin and metalloproteinase domain-containing protein 28
go.drugbank.com/bio_entities/BE0003872TargetHumansMay play a role in the adhesive and proteolytic events that occur during lymphocyte emigration or may function in ectodomain shedding of lymphocyte surface target proteins, such as FASL and CD40L.
Polypeptides: Disintegrin and metalloproteinase domain-containing protein 28Synonyms: Metalloproteinase-like, disintegrin-like, and cysteine-rich protein L, Epididymal metalloproteinase-like, disintegrin-like, and cysteine-rich protein IISodium- and chloride-dependent GABA transporter 2
go.drugbank.com/bio_entities/BE0004776TargetHumansCan also mediate transport of taurine and hypotaurine (By similarity) … Mediates sodium- and chloride-dependent transport of gamma-aminobutyric acid (GABA) (PubMed:17502375, PubMed:22932902). Mediates transport of beta-alanine (PubMed:17502375).
Polypeptides: Sodium- and chloride-dependent GABA transporter 2Calcium and integrin-binding family member 2
go.drugbank.com/bio_entities/BE0008698TargetHumansRequired for the maintenance of auditory hair cell stereocilia bundle morphology and function and for hair-cell survival in the cochlea (By similarity). … Critical for proper photoreceptor cell maintenance and function (By similarity).
Polypeptides: Calcium and integrin-binding family member 2Sodium- and chloride-dependent glycine transporter 1
go.drugbank.com/bio_entities/BE0000940TransporterTargetHumansSodium- and chloride-dependent glycine transporter (PubMed:37962965, PubMed:8183239). Essential for regulating glycine concentrations at inhibitory glycinergic synapses
Polypeptides: Sodium- and chloride-dependent glycine transporter 1Troponin C, slow skeletal and cardiac muscles
go.drugbank.com/bio_entities/BE0001024TargetHumansTn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C.
Polypeptides: Troponin C, slow skeletal and cardiac musclesSodium- and chloride-dependent glycine transporter 2
go.drugbank.com/bio_entities/BE0002310TransporterTargetHumansSodium- and chloride-dependent glycine transporter (PubMed:10381548, PubMed:10606742, PubMed:16751771, PubMed:31370103, PubMed:9845349).
Polypeptides: Sodium- and chloride-dependent glycine transporter 2Signal transducer and activator of transcription 3
go.drugbank.com/bio_entities/BE0003462TargetHumansInvolved in cell cycle regulation by inducing the expression of key genes for the progression from G1 to S phase, such as CCND1 (PubMed:17344214). … and IL6ST) (PubMed:9188471)
Polypeptides: Signal transducer and activator of transcription 3Disintegrin and metalloproteinase domain-containing protein 17
go.drugbank.com/bio_entities/BE0003754TargetHumansMediates the proteolytic cleavage and shedding of FCGR3A upon NK cell stimulation, a mechanism that allows for increased NK cell motility and detachment from opsonized target cells. … Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface (PubMed:20592283).
Polypeptides: Disintegrin and metalloproteinase domain-containing protein 17