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Tixagevimab
go.drugbank.com/drugs/DB16394ApprovedInvestigationalSARS-CoV-2, the causative agent of COVID-19, enters cells via the interaction between the trimeric spike (S) glycoprotein and host cell angiotensin-converting enzyme 2 (ACE2). … Certain SARS-CoV-2 Omicron subvariants may be associated with resistance to monoclonal antibodies, such as EVUSHELD.
Nicorandil
go.drugbank.com/drugs/DB09220ApprovedInvestigationalWithdrawnNicorandil is an orally efficacious vasodilatory drug and antianginal agent marketed in the UK, Australia, most of Europe, India, Philippines, Japan, South Korea, and Taiwan. … It is shown to dilate normal and stenotic coronary arteries and reduces both ventricular preload and afterload [A20325].
Categories: Heterocyclic Compounds, 1-RingSynonyms: N-(2-Hydroxyethyl)nicotinamide nitrate, N-(2-Hydroxyethyl)nicotinamide nitrate (ester)Trimethoprim
go.drugbank.com/drugs/DB00440ApprovedInvestigationalVet approved[L11893] Trimethoprim is often used in combination with [sulfamethoxazole] due to their complementary and synergistic mechanisms but may be used as a monotherapy in the treatment and/or prophylaxis of … Trimethoprim is an antifolate antibacterial agent that inhibits bacterial dihydrofolate reductase (DHFR), a critical enzyme that catalyzes the formation of tetrahydrofolic acid (THF) - in doing so, it
Mixtures: TS-BAC, TS-BACCategories: MATE 1 Inhibitors, MATE 1 SubstratesZinc sulfate
go.drugbank.com/drugs/DB09322ApprovedInvestigationalZinc sulfate is the inorganic compound with the formula ZnSO4 and historically known as "white vitriol". … It is on the World Health Organization's List of Essential Medicines, a list of the most important medication needed in a basic health system.
Mixtures: Micro+ Te Pediatric, M T E 4 Concentrate InjProducts: SULFATO DE ZINC 2MG/ML SOLUCION ORAL SABOR A CEREZA Y SABOR A CHICLE., EYE GLO RELIEF EYE DROPS 0.25%w/vSepetaprost
go.drugbank.com/drugs/DB12043InvestigationalSepetaprost has been used in trials studying the treatment of Open Angle-glaucoma, Ocular Hypertension, and Mild Open Angle-glaucoma (OAG).
Categories: Heterocyclic Compounds, 1-RingFerrous sulfate anhydrous
go.drugbank.com/drugs/DB13257ApprovedInvestigational[A190528] Ferrous sulfate is a synthetic agent used in the treatment of iron deficiency. It is the gold standard of oral iron therapy in the UK and many other countries.[L2234,L2246] … [A190804] This type of anemia occurs when iron intake, iron stores, and iron loss do not adequately support the formation of erythrocytes, also known as red blood cells.
Mixtures: Hormodausse Plus Calc Et D Tab, TL-Fol 500Synonyms: iron sulfate (1:1), iron(2+) sulfate (anhydrous)Phenobarbital
go.drugbank.com/drugs/DB01174ApprovedInvestigationalA barbituric acid derivative that acts as a nonselective central nervous system depressant. … It promotes binding to inhibitory gamma-aminobutyric acid subtype receptors, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.
Synonyms: 5-Ethyl-5-phenylbarbituric acid, 5-Phenyl-5-ethylbarbituric acidMixtures: Se-donna Pb Hyos, Re-PB HyosMercaptopurine Metabolism Pathway
smpdb.ca/view/SMP0000609Drug metabolismMercaptopurine is a purine antimetabolite prodrug that exerts cytotoxic effects via three mechanisms: via incorporation of thiodeoxyguanosine triphosphate into DNA and thioguanosine triphosphate into RNA, inhibition of de novo synthesis ...
Enzymes: Thiopurine S-methyltransferaseMesoridazine Dopamine Antagonist Action Pathway
smpdb.ca/view/SMP0126523Drug actionMesoridazine, the besylate salt of a metabolite of thioridazine, is a phenothiazine tranquilizer and a first generation typical antipsychotic. Based upon animal studies, mesoridazine, as with other phenothiazines, acts indirectly on reti...
Enzymes: Guanine nucleotide-binding protein G(s) subunit alpha isoforms shortQuetiapine Dopamine Antagonist Action Pathway
smpdb.ca/view/SMP0126827Drug actionQuetiapine is used in the symptomatic treatment of schizophrenia. In addition, it may be used for the management of acute manic or mixed episodes in patients with bipolar I disorder, as a monotherapy or combined with other drugs. It may ...
Enzymes: Guanine nucleotide-binding protein G(s) subunit alpha isoforms short