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Tyrosine-protein kinase receptor Tie-1
go.drugbank.com/bio_entities/BE0009396TargetHumansTransmembrane tyrosine-protein kinase that may modulate TEK/TIE2 activity and contribute to the regulation of angiogenesis
Polypeptides: Tyrosine-protein kinase receptor Tie-1Interleukin-1 receptor-associated kinase 3
go.drugbank.com/bio_entities/BE0009453TargetHumansInhibits dissociation of IRAK1 and IRAK4 from the Toll-like receptor signaling complex by either inhibiting the phosphorylation of IRAK1 and IRAK4 or stabilizing the receptor complex (By similarity).
Polypeptides: Interleukin-1 receptor-associated kinase 3Synonyms: IL-1 receptor-associated kinase M, Inactive IL-1 receptor-associated kinase 3C-C chemokine receptor type 4
go.drugbank.com/bio_entities/BE0009787TargetHumansHigh affinity receptor for the C-C type chemokines CCL17/TARC, CCL22/MDC and CKLF isoform 1/CKLF1. … The activity of this receptor is mediated by G(i) proteins which activate a phosphatidylinositol-calcium second messenger system.
Polypeptides: C-C chemokine receptor type 4Killer cell immunoglobulin-like receptor 2DL3
go.drugbank.com/bio_entities/BE0010665TargetHumansReceptor on natural killer (NK) cells for HLA-C alleles (HLA-Cw1, HLA-Cw3 and HLA-Cw7). Inhibits the activity of NK cells thus preventing cell lysis
Polypeptides: Killer cell immunoglobulin-like receptor 2DL3Synonyms: p58 NK receptor CL-6, Killer inhibitory receptor cl 2-3Baculoviral IAP repeat-containing protein 3
go.drugbank.com/bio_entities/BE0010674TargetHumansMulti-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 u...
Polypeptides: Baculoviral IAP repeat-containing protein 3Baculoviral IAP repeat-containing protein 2
go.drugbank.com/bio_entities/BE0010675TargetHumansMulti-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling, and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ...
Polypeptides: Baculoviral IAP repeat-containing protein 2Ciliary neurotrophic factor receptor subunit alpha
go.drugbank.com/bio_entities/BE0012974TargetHumansFunctions within the ciliary neurotrophic factor receptor (CNTFR) complex as a membrane-anchored non-signaling receptor subunit associated with two other signaling receptor subunits IL6ST/gp130 and LIFR … Also, functions within the humanin receptor complex as a membrane-anchored non-signaling receptor subunit associated with IL6ST/GP130 and IL27RA/WSX1 that mediates the MT-RNR2/humanin signaling which induces
Polypeptides: Ciliary neurotrophic factor receptor subunit alphaSynonyms: CNTF receptor subunit alphaG protein-coupled receptor kinase 5
go.drugbank.com/bio_entities/BE0013072TargetHumansSuch receptor phosphorylation initiates beta-arrestin-mediated receptor desensitization, internalization, and signaling events leading to their down-regulation. … Phosphorylation of ST13 regulates internalization of the chemokine receptor. Phosphorylates rhodopsin (RHO) (in vitro) and a non G protein-coupled receptor, LRP6 during Wnt signaling (in vitro)
Polypeptides: G protein-coupled receptor kinase 5Synonyms: G protein-coupled receptor kinase GRK5Interleukin-12 receptor subunit beta-1
go.drugbank.com/bio_entities/BE0013218TargetHumansFunctions as an interleukin receptor which binds interleukin-12 with low affinity and is involved in IL12 transduction. Associated with IL12RB2 it forms a functional, high affinity receptor for IL12. … Also associates with IL23R to form the interleukin-23 receptor which functions in IL23 signal transduction probably through activation of the Jak-Stat signaling cascade
Polypeptides: Interleukin-12 receptor subunit beta-1Synonyms: IL-12 receptor beta component, IL-12 receptor subunit beta-1Short transient receptor potential channel 1
go.drugbank.com/bio_entities/BE0013282TargetHumansForms a receptor-activated non-selective calcium permeant cation channel (PubMed:11139478, PubMed:15016832, PubMed:39478185).
Polypeptides: Short transient receptor potential channel 1Synonyms: Transient receptor protein 1