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ATP-binding cassette sub-family C member 6
go.drugbank.com/bio_entities/BE0003640TransporterTargetHumansMediates ATP-dependent transport of glutathione conjugates such as leukotriene-c4 (LTC4) and N-ethylmaleimide S-glutathione (NEM-GS) (in vitro), and an anionic cyclopentapeptide endothelin antagonist,
Function: ABC-type glutathione S-conjugate transporter activity2-Hydroxyacid oxidase 1
go.drugbank.com/bio_entities/BE0003766TargetEnzymeHumansBroad substrate specificity (S)-2-hydroxy-acid oxidase that preferentially oxidizes glycolate (PubMed:10777549, PubMed:10978532, PubMed:17669354, PubMed:18215067).
Function: (S)-2-hydroxy-acid oxidase activityAdenylosuccinate lyase
go.drugbank.com/bio_entities/BE0012967TargetEnzymeHumansCatalyzes two non-sequential steps in de novo AMP synthesis: converts (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate (SAICAR) to fumarate plus 5-amino-1-(5-phospho-D-ribosyl)imidazole
Function: (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido) succinate lyase (fumarate-forming) activity4-hydroxy-tetrahydrodipicolinate synthase
go.drugbank.com/bio_entities/BE0001460TargetThermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
Allantoate amidohydrolase
go.drugbank.com/bio_entities/BE0001602TargetEscherichia coli (strain K12)Catalyzes specifically the hydrolysis of allantoate to yield CO2, NH3 and S-ureidoglycine, which is unstable and readily undergoes a second deamination by S-ureidoglycine aminohydrolase AllE to yield S-ureidoglycolate … In vivo, the spontaneous release of S-ureidoglycolate and ammonia from S-ureidoglycine appears to be too slow to sustain an efficient flux of nitrogen (PubMed:20038185).
Polyunsaturated fatty acid lipoxygenase ALOX15
go.drugbank.com/bio_entities/BE0000309TargetEnzymeHumansNon-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids generating a spectrum of bioactive lipid mediators (PubMed:17052953, PubMed:1944593, PubMed:24282679,...
Function: arachidonate 12(S)-lipoxygenase activityPolyunsaturated fatty acid 5-lipoxygenase
go.drugbank.com/bio_entities/BE0000248TargetEnzymeHumansCatalyzes the oxygenation of arachidonate ((5Z,8Z,11Z,14Z)-eicosatetraenoate) to 5-hydroperoxyeicosatetraenoate (5-HPETE) followed by the dehydration to 5,6- epoxyeicosatetraenoate (Leukotriene A4/LTA4), the first two steps in the biosyn...
Function: arachidonate 12(S)-lipoxygenase activityMethionine adenosyltransferase 2 subunit beta
go.drugbank.com/bio_entities/BE0002178EnzymeHumansRegulatory subunit of S-adenosylmethionine synthetase 2, an enzyme that catalyzes the formation of S-adenosylmethionine from methionine and ATP.
Polyunsaturated fatty acid lipoxygenase ALOX12
go.drugbank.com/bio_entities/BE0012732TargetHumansCatalyzes the regio and stereo-specific incorporation of molecular oxygen into free and esterified polyunsaturated fatty acids generating lipid hydroperoxides that can be further reduced to the corresponding hydroxy species (PubMed:17493...
Function: arachidonate 12(S)-lipoxygenase activitySpermine synthase
go.drugbank.com/bio_entities/BE0000964TargetHumansCatalyzes the production of spermine from spermidine and decarboxylated S-adenosylmethionine (dcSAM)