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Displaying results 131 - 140 of 509 in total
  1. Target

    V-type sodium ATPase subunit K

    go.drugbank.com/bio_entities/BE0001440
    TargetEnterococcus hirae (strain ATCC 9790 / DSM 20160 / JCM 8729 / LMG 6399 / NBRC 3181 / NCIMB 6459 / NCDO 1258)

    Involved in ATP-driven sodium extrusion.

    Polypeptides: V-type sodium ATPase subunit KSynonyms: Sodium ATPase proteolipid component
  2. Target

    Sodium channel regulatory subunit beta-4

    go.drugbank.com/bio_entities/BE0003638
    TargetHumans

    Navs, also called VGSCs (voltage-gated sodium channels) or VDSCs (voltage-dependent sodium channels), operate by switching between closed and open conformations depending on the voltage difference across … The influx of Na+ ions provokes membrane depolarization, initiating the propagation of electrical signals throughout cells and tissues.

    Polypeptides: Sodium channel regulatory subunit beta-4Function: sodium channel regulator activity
  3. Target

    Sodium-dependent phosphate transport protein 2A

    go.drugbank.com/bio_entities/BE0008681
    TransporterHumans

    The cotransport has a Na(+):Pi stoichiometry of 3:1 and is electrogenic (By similarity)

    Polypeptides: Sodium-dependent phosphate transport protein 2ASynonyms: Sodium/phosphate cotransporter 2A, Sodium-phosphate transport protein 2A
  4. Target

    Sodium-dependent phosphate transport protein 2B

    go.drugbank.com/bio_entities/BE0008682
    TransporterTargetHumans

    Involved in actively transporting phosphate into cells via Na(+) cotransport

    Polypeptides: Sodium-dependent phosphate transport protein 2BSynonyms: Sodium/phosphate cotransporter 2B, Sodium-phosphate transport protein 2B
  5. Target

    Sodium-dependent phosphate transport protein 2C

    go.drugbank.com/bio_entities/BE0008683
    TransporterHumans

    The cotransport has a Na(+):Pi stoichiometry of 2:1 and is electroneutral (By similarity)

    Polypeptides: Sodium-dependent phosphate transport protein 2CSynonyms: Sodium/phosphate cotransporter 2C, Sodium-phosphate transport protein 2C
  6. Target

    MAP kinase-activated protein kinase 5

    go.drugbank.com/bio_entities/BE0009478
    TargetHumans

    Tumor suppressor serine/threonine-protein kinase involved in mTORC1 signaling and post-transcriptional regulation. Phosphorylates FOXO3, ERK3/MAPK6, ERK4/MAPK4, HSP27/HSPB1, p53/TP53 and RHEB. … Acts as a tumor suppressor by mediating Ras-induced senescence and phosphorylating p53/TP53.

    Polypeptides: MAP kinase-activated protein kinase 5Synonyms: MAPK-activated protein kinase 5, p38-regulated/activated protein kinase
  7. Target

    MAP kinase-activated protein kinase 2

    go.drugbank.com/bio_entities/BE0001373
    TargetHumans

    Following stress, it is phosphorylated and activated by MAP kinase p38-alpha/MAPK14, leading to phosphorylation of substrates. … PABPC1 and TTP/ZFP36, leading to the regulation of the stability and translation of TNF and IL6 mRNAs.

    Polypeptides: MAP kinase-activated protein kinase 2Synonyms: MAPK-activated protein kinase 2
  8. Target

    Sodium/potassium-transporting ATPase subunit gamma

    go.drugbank.com/bio_entities/BE0000229
    TargetEnzymeTransporterHumans

    May be involved in forming the receptor site for cardiac glycoside binding or may modulate the transport function of the sodium ATPase

    Polypeptides: Sodium/potassium-transporting ATPase subunit gammaSynonyms: Sodium pump gamma chain
  9. Target

    Sodium channel regulatory subunit beta-3

    go.drugbank.com/bio_entities/BE0003637
    TargetHumans

    Navs, also called VGSCs (voltage-gated sodium channels) or VDSCs (voltage-dependent sodium channels), operate by switching between closed and open conformations depending on the voltage difference across … The influx of Na+ ions provokes membrane depolarization, initiating the propagation of electrical signals throughout cells and tissues.

    Polypeptides: Sodium channel regulatory subunit beta-3Function: sodium channel inhibitor activity
  10. Target

    Voltage-gated sodium channel alpha subunit

    go.drugbank.com/bio_entities/BE0009738
    TargetHumans

    Sodium leak channel functioning as an osmosensor regulating sodium ion levels in various tissues and organs. … While most sodium channels are voltage-gated, SCN7A is not and lets sodium flow through membrane along its concentration gradient (PubMed:26537257, PubMed:35301303).

    Polypeptides: Sodium channel protein type 1 subunit alpha, Sodium channel protein type 10 subunit alphaSynonyms: Peripheral nerve sodium channel 3, Peripheral sodium channel 1