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Displaying results 131 - 140 of 561 in total
  1. Target

    Fibronectin receptor

    go.drugbank.com/bio_entities/BE0010279
    TargetHumans

    Integrins ITGA9:ITGB1 and ITGA4:ITGB1 repress PRKCA-mediated L-type voltage-gated channel Ca(2+) influx and ROCK-mediated calcium sensitivity in vascular smooth muscle cells via their interaction with

    Function: calcium ion binding
  2. Target

    Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform

    go.drugbank.com/bio_entities/BE0012731
    TargetHumans

    Calcium-dependent, calmodulin-stimulated protein phosphatase which plays an essential role in the transduction of intracellular Ca(2+)-mediated signals (PubMed:19154138, PubMed:25720963, PubMed:26794871

    Function: calcium ion binding
  3. Target

    NADPH oxidase 5

    go.drugbank.com/bio_entities/BE0018640
    TargetHumans

    Calcium-dependent NADPH oxidase that catalyzes the generation of superoxide from molecular oxygen utilizing NADPH as an electron donor (PubMed:12686516).

    Function: calcium ion binding
  4. Target

    Bcl-2-like protein 10

    go.drugbank.com/bio_entities/BE0019838
    TargetHumans

    Reduces ITPR1-mediated calcium release from the endoplasmic reticulum cooperatively with AHCYL1/IRBIT under normal cellular conditions (PubMed:27995898).

    Function: calcium ion binding
  5. Target

    Transient receptor potential cation channel subfamily M member 5

    go.drugbank.com/bio_entities/BE0020643
    TargetHumans

    and leads to the breakdown of phosphatidylinositol bisphosphate (PIP2) into diacylglycerol (DAG) and inositol trisphosphate (IP3), IP3 binds to its receptors in the endoplasmic reticulum and cause calcium

    Function: calcium ion binding
  6. Target

    Osteocalcin

    go.drugbank.com/bio_entities/BE0000724
    TargetHumans

    Binds strongly to apatite and calcium upon gamma-carboxylation; this modification is essential for bone metabolism (PubMed:6967872, PubMed:39880952)

    Function: calcium ion binding
  7. Target

    Protein-glutamine gamma-glutamyltransferase 2

    go.drugbank.com/bio_entities/BE0001035
    TargetEnzymeHumans

    Calcium-dependent acyltransferase that catalyzes the formation of covalent bonds between peptide-bound glutamine and various primary amines, such as gamma-amino group of peptide-bound lysine, or mono-

    Function: calcium ion binding
  8. Target

    SPARC

    go.drugbank.com/bio_entities/BE0002145
    TargetHumans

    Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. … There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity

    Function: calcium ion binding
  9. Target

    Anoctamin-1

    go.drugbank.com/bio_entities/BE0004746
    TargetHumans

    Calcium-activated chloride channel (CaCC) (PubMed:20056604, PubMed:22178883, PubMed:22946059, PubMed:32487539). Plays a role in transepithelial anion transport and smooth muscle contraction. … Responsible for calcium-activated chloride channel activity in type I taste cells of the vallate papillae (By similarity). Acts as a heat sensor in nociceptive neurons (By similarity).

    Function: calcium-activated cation channel activity
  10. Target

    Programmed cell death protein 6

    go.drugbank.com/bio_entities/BE0005812
    TargetHumans

    Acts as an adapter that bridges unrelated proteins or stabilizes weak protein-protein complexes in response to calcium: calcium-binding triggers exposure of apolar surface, promoting interaction with different … Calcium sensor that plays a key role in processes such as endoplasmic reticulum (ER)-Golgi vesicular transport, endosomal biogenesis or membrane repair.

    Function: calcium ion binding