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Sodium-coupled neutral amino acid transporters
go.drugbank.com/bio_entities/BE0009976TargetHumansSymporter that cotransports specific neutral amino acids and sodium ions, coupled to an H(+) antiporter activity (PubMed:10823827). … The transport is pH-sensitive, Li(+)-intolerant, electrogenic, driven by the Na(+) electrochemical gradient and cotransports of neutral amino acids and sodium ions with a stoichiometry of 1:1.
Polypeptides: Sodium-coupled neutral amino acid symporter 1, Sodium-coupled neutral amino acid symporter 2Sodium channel regulatory subunit beta-1
go.drugbank.com/bio_entities/BE0003635TargetHumansNavs, also called VGSCs (voltage-gated sodium channels) or VDSCs (voltage-dependent sodium channels), operate by switching between closed and open conformations depending on the voltage difference across … The accessory beta subunits participate in localization and functional modulation of the Nav channels (PubMed:15525788, PubMed:19710327, PubMed:29992740).
Polypeptides: Sodium channel regulatory subunit beta-1Function: sodium channel inhibitor activitySodium channel regulatory subunit beta-2
go.drugbank.com/bio_entities/BE0003636TargetHumansNavs, also called VGSCs (voltage-gated sodium channels) or VDSCs (voltage-dependent sodium channels), operate by switching between closed and open conformations depending on the voltage difference across … The accessory beta subunits participate in localization and functional modulation of the Nav channels (PubMed:19808477, PubMed:23559163).
Polypeptides: Sodium channel regulatory subunit beta-2Function: sodium channel regulator activityPotassium channel subfamily T member 1
go.drugbank.com/bio_entities/BE0015369TargetHumansSodium-activated K(+) channel (PubMed:37494189). Acts as an important mediator of neuronal membrane excitability (PubMed:37494189). Contributes to the delayed outward currents (By similarity). … Contributes to synaptic development and plasticity (By similarity)
Synonyms: Sodium and chloride-activated ATP-sensitive potassium channel Slo2.2Function: chloride-activated potassium channel activityMitogen-activated protein kinase kinase kinase 1
go.drugbank.com/bio_entities/BE0003430TargetHumansActivates CHUK and IKBKB, the central protein kinases of the NF-kappa-B pathway (PubMed:9808624) … Activates the ERK and JNK kinase pathways by phosphorylation of MAP2K1 and MAP2K4 (PubMed:9808624). May phosphorylate the MAPK8/JNK1 kinase (PubMed:17761173).
Polypeptides: Mitogen-activated protein kinase kinase kinase 1Mitogen-activated protein kinase kinase kinase 11
go.drugbank.com/bio_entities/BE0009463TargetHumansActivates the JUN N-terminal pathway. … Required for serum-stimulated cell proliferation and for mitogen and cytokine activation of MAPK14 (p38), MAPK3 (ERK) and MAPK8 (JNK1) through phosphorylation and activation of MAP2K4/MKK4 and MAP2K7/MKK7
Polypeptides: Mitogen-activated protein kinase kinase kinase 11Mitogen-activated protein kinase kinase kinase 13
go.drugbank.com/bio_entities/BE0009465TargetHumansThis activation is kinase-dependent and involves activating the IKK complex, the IKBKB-containing complex that phosphorylates inhibitors of NF-kappa-B … Activates the JUN N-terminal pathway through activation of the MAP kinase kinase MAP2K7. Acts synergistically with PRDX3 to regulate the activation of NF-kappa-B in the cytosol.
Polypeptides: Mitogen-activated protein kinase kinase kinase 13Mitogen-activated protein kinase kinase kinase 15
go.drugbank.com/bio_entities/BE0009466TargetHumansOnce activated, acts as an upstream activator of the p38 MAPK signal transduction cascade through the phosphorylation and activation of several MAP kinase kinases (PubMed:20362554, PubMed:26732173). … May function in a signal transduction pathway that is activated by various cell stresses and leads to apoptosis (PubMed:20362554).
Polypeptides: Mitogen-activated protein kinase kinase kinase 15Mitogen-activated protein kinase kinase kinase 8
go.drugbank.com/bio_entities/BE0010492TargetHumansTransduces CD40 and TNFRSF1A signals that activate ERK in B-cells and macrophages, and thus may play a role in the regulation of immunoglobulin production. … In vitro, activates MAPK/ERK pathway in response to IL1 in an IRAK1-independent manner, leading to up-regulation of IL8 and CCL4.
Polypeptides: Mitogen-activated protein kinase kinase kinase 8Sodium channel protein type 11 subunit alpha
go.drugbank.com/bio_entities/BE0000192TargetHumansSodium channel mediating the voltage-dependent sodium ion permeability of excitable membranes. … Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which sodium ions may pass in accordance with their
Polypeptides: Sodium channel protein type 11 subunit alphaSynonyms: Peripheral nerve sodium channel 5, Sensory neuron sodium channel 2