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Metabolism and Physiological Effects of N-Acetyl-3-Methylhistidine
smpdb.ca/view/SMP0126795MetabolicN-Acetyl-3-methylhistidine, an N-acetyl-L-amino acid, belongs to the class of organic compounds known as histidine and derivatives. … N-Acetyl-3-methylhistidine is an acetylated derivative of 3-methylhistidine and a very strong basic compound (based on its pKa).
Metabolism and Physiological Effects of N-alpha-Acetyl-L-arginine
smpdb.ca/view/SMP0125530MetabolicArginnosuccinate is synthesized from citrulline and aspartic acid by the enzyme argininosuccinate synthase. That is catalyzed by argininosuccinate lyase to produce arginine and fumaric acid. … In the blood it works as a uremic toxin to cause kidney damage, cardiovascular disease and neurological deficits.
Drugs: Pyridoxal phosphate · Arginine · Aspartic acid · Ornithine · L-Glutamine · Adenosine phosphate +10 moreEnzymes: Calcium-binding mitochondrial carrier protein Aralar1Ziconotide NMDA and Substance P Receptor Pain Inhibition Action Pathway
smpdb.ca/view/SMP0126347Drug actionVoltage-gated calcium channels (VGCCs) are important regulatory components of neural signalling, including type-N voltage-gated calcium channels. … such as intrathecal morphine and systemic analgesics.
Enzymes: Voltage-dependent L-type calcium channel subunit beta-4, Voltage-dependent L-type calcium channel subunit beta-1Icosapent Prostaglandin G/H synthase 1 and 2 anti-inflammatory Action Pathway
smpdb.ca/view/SMP0126557Drug actionThis molecule also inhibits the arachidonic acid conversion into the thromboxane-2 and prostaglandin-2 families because it inhibits the prostaglandin G/H synthase 1 and 2 (COX-1 and COX-2). … Then icosapent shows anti-atherogenic and anti-thrombotic effects in cells. EPA serves as a substrate for Prostaglandin-endoperoxide synthase 1 and 2.
Fish oil Prostaglandin G/H synthase 1 and 2 anti-inflammatory Action Pathway
smpdb.ca/view/SMP0126563Drug actionEPA and DHA do competition with arachidonic acids for both COX-1 and COX-2 enzymes. … These are responsible for the conversion of arachidonic acid (an omega-6 fatty acid) into prostaglandins and thromboxanes, which are important mediators of inflammation and pain.
Sulfite Oxidase Deficiency
smpdb.ca/view/SMP0125709DiseaseIn classic SOD, it is usually identified a few days after the birth of an affected individual, and is recognizable through characteristic dysmorphic features, seizures, and other signs of progressive encephalopathy … Sulfite oxidase deficiency (SOD) is a disorder, an autosomal recessive disease.
Enzymes: Sulfite oxidase, mitochondrialSulfite Oxidase Deficiency
smpdb.ca/view/SMP0000532DiseaseIn classic SOD, it is usually identified a few days after the birth of an affected individual, and is recognizable through characteristic dysmorphic features, seizures, and other signs of progressive encephalopathy … Sulfite oxidase deficiency (SOD) is a disorder, an autosomal recessive disease.
Enzymes: Sulfite oxidase, mitochondrialAromatase Deficiency
smpdb.ca/view/SMP0000565DiseaseSymptoms of decrease in estrogen and increase androgens such as testosterone can cause impaired female sexual development, unusual bone growth, insulin resistance, and a variety of other symptoms. … Aromatase converts androgens to estrogens which is vital for bone growth and regulation of blood sugar levels.
Enzymes: Steryl-sulfatase17-beta Hydroxysteroid Dehydrogenase III Deficiency
smpdb.ca/view/SMP0125781Diseasedisorder of the androgen and estrogen metabolism pathway. … This leads to an accumulation of androstenedione and dehydroepiandrosterone in the body, as well as a lack of testosterone produced. 17-KSR deficiency is characterized by an absence of testosterone in
Enzymes: Steryl-sulfatase17-beta Hydroxysteroid Dehydrogenase III Deficiency
smpdb.ca/view/SMP0000356Diseasedisorder of the androgen and estrogen metabolism pathway. … This leads to an accumulation of androstenedione and dehydroepiandrosterone in the body, as well as a lack of testosterone produced. 17-KSR deficiency is characterized by an absence of testosterone in
Enzymes: Steryl-sulfatase