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Sulindac Action Pathway (New)
smpdb.ca/view/SMP0126555Drug actionThe low concentration of prostaglandin E2 attenuates the effect it has on stimulating immune cells and pain fibers, consequently reducing inflammation and pain. … Sulindac (its sulfide metabolite) inhibits the action of COX-1 and COX-2 on the endoplasmic reticulum membrane. This reduces the formation of prostaglandin H2 and therefore, prostaglandin E2 (PGE2).
Neostigmine Action Pathway (new)
smpdb.ca/view/SMP0126669Drug actionThe sodium causes depolarization of the cell, opening voltage-gated calcium channels on the sarcoplasmic reticulum. Calcium enters the cytosol from the sarcoplasmic reticulum and binds to calmodulin. … In the neuron, acetylcholine is synthesized from acetyl-coa and choline, and stored into synaptic vesicles.
Enzymes: Voltage-dependent L-type calcium channel subunit beta-4, Voltage-dependent L-type calcium channel subunit alpha-1FTriflusal Action Pathway (new)
smpdb.ca/view/SMP0126547Drug actionDue to the anticoagulant and antiplatelet nature, herbs and supplements with similar activity should be avoided such as garlic, ginger, bilberry, danshen, piracetam and ginkgo biloba. … Triflusal is administered orally and acts as an antithrombotic anticoagulant that irreversibly inhibits cyclooxygenase-1(COX-1) also known as prostaglandin g/h synthase 1.
Drugs: Adenosine phosphate · ATP · Magnesium cation · Zinc · Cyclic adenosine monophosphate · Mesoheme +2 moreEnzymes: cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10APhysostigmine Action Pathway
smpdb.ca/view/SMP0125085Drug actionWhen an action potential arrives at the nerve terminal, voltage gated calcium channels open leading to an influx of calcium ions into the neuron. … In the neuron, acetylcholine is synthesized form acetyl-coa and choline, and stored into synaptic vesicles.
Enzymes: Voltage-dependent L-type calcium channel subunit beta-4, Voltage-dependent L-type calcium channel subunit beta-1Atropine M1/3/5 Muscarinic Poisoning Action Pathway
smpdb.ca/view/SMP0125413Drug actionentering the cell which means calcium does not readily bind to calmodulin, and calmodulin isn't present to activate myosin light chain kinase. … IP3 would then activate IP3 receptors on the sarcoplasmic reticulum leading to the release of stored calcium into the cytosol. the muscarinic acetylcholine receptors being inhibited prevents calcium from
Enzymes: Voltage-dependent P/Q-type calcium channel subunit alpha-1A, Voltage-dependent L-type calcium channel subunit beta-1Famotidine H2 Anti-Histamine Action Pathway
smpdb.ca/view/SMP0126789Drug actionFamotidine inhibits both basal and nocturnal gastric acid secretion, as well as acid secretion stimulated by food, caffeine, insulin, and pentagastrin. … Famotidine is a histamine H2 receptor antagonist used to treat gastroesophageal reflux disease and various ulcers.
Drugs: ATP · Famotidine · Potassium cation · Magnesium cation · Zinc · Cyclic adenosine monophosphateMetiamide H2 Anti-Histamine Action Pathway
smpdb.ca/view/SMP0123167Drug actionMetiamide is an histamine H2 receptor antagonist used to treat stomach ulcers and Gastroesophageal Reflux Disease (GERD). … After being taken orally, it is absorbed in the GI tract and travels through the blood to get to the stomach epithelium.
Drugs: ATP · Potassium cation · Magnesium cation · Zinc · Cyclic adenosine monophosphate · MetiamideNizatidine H2 Anti-Histamine Action Pathway
smpdb.ca/view/SMP0126776Drug actionNizatidine is an H2 Histamine receptor antagonist used to treat acid reflux disorders and a variety of ulcers. Nizatidine is taken orally as a solution or a capsule.
Drugs: ATP · Nizatidine · Potassium cation · Magnesium cation · Zinc · Cyclic adenosine monophosphateLavoltidine H2 Anti-histamine Action Pathway
smpdb.ca/view/SMP0126790Drug actionLavoltidine has been used in trials studying the diagnostic of Reflux, Gastroesophageal and Gastroesophageal Reflux Disease. … After being taken orally, it is absorbed in the GI tract and travels through the blood to get to the stomach epithelium.
Drugs: ATP · Potassium cation · Magnesium cation · Zinc · Cyclic adenosine monophosphate · LavoltidineNGX267 Action Pathway
smpdb.ca/view/SMP0126364Drug actionIt is developed for the treatment of Alzheimer’s disease and has shown the potential to both reduce symptoms and slow disease progression. … The M1 receptor plays an important role in memory and cognitive processing.
Enzymes: Voltage-dependent L-type calcium channel subunit beta-4, Voltage-dependent L-type calcium channel subunit beta-1