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Solute carrier family 12 member 4
go.drugbank.com/bio_entities/BE0000601TargetTransporterHumansMediates electroneutral potassium-chloride cotransport when activated by cell swelling (PubMed:35759661). May contribute to cell volume homeostasis in single cells (PubMed:10913127, PubMed:34031912).
Synonyms: Electroneutral potassium-chloride cotransporter 1Adiponectin receptor
go.drugbank.com/bio_entities/BE0010287TargetHumansRequired for normal glucose and fat homeostasis and for maintaining a normal body weight. … Receptor for ADIPOQ, an essential hormone secreted by adipocytes that regulates glucose and lipid metabolism (PubMed:12802337, PubMed:25855295). Required for normal body fat and glucose homeostasis.
Synonyms: Progestin and adipoQ receptor family member 1, Progestin and adipoQ receptor family member ISolute carrier family 12 member 5
go.drugbank.com/bio_entities/BE0000047TargetTransporterHumansMediates electroneutral potassium-chloride cotransport in mature neurons and is required for neuronal Cl(-) homeostasis (PubMed:12106695). … and neuronal inhibition (By similarity).
Synonyms: Electroneutral potassium-chloride cotransporter 2Solute carrier family 12 member 5
go.drugbank.com/bio_entities/BE0009674TransporterMouseMediates electroneutral potassium-chloride cotransport in mature neurons and is required for neuronal Cl(-) homeostasis (By similarity). … and neuronal inhibition (By similarity).
Synonyms: Electroneutral potassium-chloride cotransporter 2Solute carrier family 12 member 2
go.drugbank.com/bio_entities/BE0000281TargetTransporterHumansCation-chloride cotransporter which mediates the electroneutral transport of chloride, potassium and/or sodium ions across the membrane (PubMed:16669787, PubMed:32081947, PubMed:32294086, PubMed:33597714 … Plays a vital role in the regulation of ionic balance and cell volume (PubMed:16669787, PubMed:32081947, PubMed:32294086, PubMed:7629105)
Synonyms: Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 2Solute carrier family 12 member 1
go.drugbank.com/bio_entities/BE0000502TargetTransporterHumansRenal sodium, potassium and chloride non-electrogenic ion symporter that mediates the transepithelial NaCl reabsorption in the thick ascending limb and plays an essential role in the urinary concentration … and volume regulation (PubMed:21321328).
Synonyms: Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 1Immunoglobulin J chain
go.drugbank.com/bio_entities/BE0009083TargetHumansIn the case of IgM, the J chain-joined dimer is a nucleating unit for the IgM pentamer, and in the case of IgA it induces dimers and/or larger polymers.
Synonyms: Joining chain of multimeric IgA and IgMProlyl 3-hydroxylase OGFOD1
go.drugbank.com/bio_entities/BE0002210TargetHumansProlyl 3-hydroxylase that catalyzes 3-hydroxylation of 'Pro-62' of small ribosomal subunit uS12 (RPS23), thereby regulating protein translation termination efficiency. Involved in stress granule formation
Synonyms: Termination and polyadenylation 1 homolog, 2-oxoglutarate and iron-dependent oxygenase domain-containing protein 1Complement C5
go.drugbank.com/bio_entities/BE0000855TargetHumansPrecursor of the C5a anaphylatoxin and complement C5b components of the complement pathways, which consist in a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that … Activated downstream of classical, alternative, lectin and GZMK complement pathways (PubMed:12878586, PubMed:18204047, PubMed:30643019, PubMed:39914456, PubMed:39814882, PubMed:6554279)
Synonyms: C3 and PZP-like alpha-2-macroglobulin domain-containing protein 4Complement C3
go.drugbank.com/bio_entities/BE0003455TargetHumansPrecursor of non-enzymatic components of the classical, alternative, lectin and GZMK complement pathways, which consist in a cascade of proteins that leads to phagocytosis and breakdown of pathogens and
Synonyms: C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1