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Displaying results 141 - 150 of 134502 in total
  1. Pathway

    Amlodipine Action Pathway

    smpdb.ca/view/SMP0000376
    Drug action

    Amlodipine inhibits the influx of calcium ions into vascular smooth muscle and cardiac muscle to bind calmodulin. … Amlodipine has arterial selectivity due to alternative splicing of the channel and has little effect on cardiac muscle.

    Drugs: ATP · Amlodipine · Potassium cation · Calcium
    Enzymes: Potassium channel subfamily K member 1, Inward rectifier potassium channel 4
  2. Pathway

    Nitrendipine Action Pathway

    smpdb.ca/view/SMP0000382
    Drug action

    Without calcium ions in muscle cell, calmodulin couldn't form the calcium-bound calmodulin, which is required for binding and activating MLCK. … Lack of initial influx of calcium can also reduce the level of contractile activity of muscle cells and results in vasodilation, which ultimately lead to overall decresing in blood pressure.

    Drugs: ATP · Nitrendipine · Potassium cation · Calcium
    Enzymes: Potassium channel subfamily K member 1, Inward rectifier potassium channel 4
  3. Pathway

    Striated Muscle Contraction

    smpdb.ca/view/SMP0000588
    Physiological

    The fast influx of sodium and slow efflux of potassium through the channel causes depolarization. … the sodium/potassium channels to be opened.

    Drugs: ATP · Potassium cation · Calcium
    Enzymes: Potassium channel subfamily K member 1, Inward rectifier potassium channel 4
  4. Pathway

    Bupranolol Action Pathway

    smpdb.ca/view/SMP0000670
    Drug action

    Bupranolol is a nonselective beta-blocker with structural similarity to propanolol. Both drugs do not have intrinsic sympathomimetic activity. It competes with catecholamines for binding beta-1 adrenergic receptors in the heart to inhibi...

    Drugs: ATP · Potassium cation · Calcium · Bupranolol
    Enzymes: Potassium channel subfamily K member 1, Inward rectifier potassium channel 4
  5. Pathway

    Digoxin Cardiac Action Pathway

    smpdb.ca/view/SMP0125107
    Drug action

    Common side effects of digoxin include nausea, vomiting, and anorexia, rash, headache, gynecomastia and weakness. … Digoxin is a positive inotropic and negative chronotropic drug, meaning that it increases the force of the heartbeat and decreases the heart rate.

    Drugs: Digoxin · Potassium cation · Calcium
    Enzymes: Sodium/potassium-transporting ATPase subunit alpha-1, Sodium/potassium-transporting ATPase subunit beta-1
  6. Pathway

    Amiloride Action Pathway (New)

    smpdb.ca/view/SMP0126243
    Drug action

    potential of the tubular lumen and reduces both potassium and hydrogen secretion and their subsequent excretion. … Negative potential reduces secretion of potassium and hydrogen ions. Amiloride is used in conjunction with diuretics to spare potassium loss.

    Drugs: Amiloride · Potassium cation · Urea
    Enzymes: Sodium/potassium-transporting ATPase subunit alpha-1, Sodium/potassium-transporting ATPase subunit beta-1
  7. Pathway

    Polythiazide Diuretic Action Pathway

    smpdb.ca/view/SMP0123144
    Drug action

    In the distal convoluted tubule (DCT), the regulation of ions such as sodium, potassium, calcium, chloride, and magnesium occurs. … The apical membrane contains a calcium channel that transports calcium from the lumen into the epithelial cell, a potassium channel that transports K+ out of the epithelial cell, and a Na+/Cl- cotransporter

    Drugs: Polythiazide · Potassium cation · Calcium
    Enzymes: Sodium/potassium-transporting ATPase subunit alpha-1, Sodium/potassium-transporting ATPase subunit beta-1
  8. Pathway

    Cyclothiazide Diuretic Action Pathway

    smpdb.ca/view/SMP0123145
    Drug action

    In the distal convoluted tubule (DCT), the regulation of ions such as sodium, potassium, calcium, chloride and magnesium occur. … The apical membrane contains a calcium channel which transports calcium from the lumen into the epithelial cell, a potassium channel which transports K+ out of the epithelial cell and a Na+/Cl- cotransporter

    Drugs: Cyclothiazide · Potassium cation · Calcium
    Enzymes: Sodium/potassium-transporting ATPase subunit alpha-1, Sodium/potassium-transporting ATPase subunit beta-1
  9. Pathway

    Benzthiazide Action Pathway

    smpdb.ca/view/SMP0126366
    Drug action

    In consequence, this will increase potassium excretion via the sodium-potassium exchange mechanism. The exact name of the inhibited transporter is the solute carrier family 12 member 3. … An overdose of benzthiazide would result in symptoms like nausea, vomiting, drowsiness, and urinary problems. This drug is administered as an oral tablet.

    Drugs: Benzthiazide · Potassium cation · Calcium
    Enzymes: Sodium/potassium-transporting ATPase subunit alpha-1, Sodium/potassium-transporting ATPase subunit beta-1
  10. Pathway

    Alprenolol Action Pathway

    smpdb.ca/view/SMP0000297
    Drug action

    Without renin, angiotensin II and aldosterone could not be produced, which ultimately prevent water retention and vasoconstriction. … Blocking beta-1 adrenergic receptor could prevent the binding of epinephrine and norepinephrine, which could efficiently reduce blood pressure and heart rate.

    Drugs: ATP · Alprenolol · Potassium cation · Calcium
    Enzymes: Potassium channel subfamily K member 1, Inward rectifier potassium channel 4