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Pancreatic adenocarcinoma up-regulated factor
go.drugbank.com/bio_entities/BE0018243TargetHumansPlays an important role in pancreatic tumor progression and metastasis (PubMed:19302292, PubMed:36232715). … Promotes pancreatic cancer cells migration and invasion through the TLR4/MyD88/NF-kappaB signaling pathway, without the involvement of the TLR4/TRIF pathway (PubMed:36232715)
Polypeptides: Pancreatic adenocarcinoma up-regulated factorSplicing factor 3B subunit 5
go.drugbank.com/bio_entities/BE0018936TargetHumansSequence independent binding of SF3A and SF3B subcomplexes upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA (PubMed:12234937). … The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA
Polypeptides: Splicing factor 3B subunit 5Synonyms: Pre-mRNA-splicing factor SF3b 10 kDa subunitSodium- and chloride-dependent GABA transporter 1
go.drugbank.com/bio_entities/BE0000249TargetHumans+), Cl(-) and GABA (By similarity). … The direction and magnitude of GABA transport is a consequence of the prevailing thermodynamic conditions, determined by membrane potential and the intracellular and extracellular concentrations of Na(
Polypeptides: Sodium- and chloride-dependent GABA transporter 1Sodium- and chloride-dependent creatine transporter 1
go.drugbank.com/bio_entities/BE0000375TargetTransporterHumansPlays an important role in supplying creatine to the brain via the blood-brain barrier (By similarity)
Polypeptides: Sodium- and chloride-dependent creatine transporter 1Signal transducer and activator of transcription 5B
go.drugbank.com/bio_entities/BE0000891TargetHumansSignal transducer and transcription activator that mediates cellular responses to cytokines, hormones and growth factors (PubMed:29844444, PubMed:9188471). … Binds to the GAS element and activates PRL-induced transcription. Positively regulates hematopoietic/erythroid differentiation.
Polypeptides: Signal transducer and activator of transcription 5BDisintegrin and metalloproteinase domain-containing protein 10
go.drugbank.com/bio_entities/BE0002404TargetHumansResponsible for the proteolytic release of several other cell-surface proteins, including heparin-binding epidermal growth-like factor, ephrin-A2, CD44, CDH2 and for constitutive and regulated alpha-secretase … Transmembrane metalloprotease which mediates the ectodomain shedding of a myriad of transmembrane proteins, including adhesion proteins, growth factor precursors and cytokines being essential for development
Polypeptides: Disintegrin and metalloproteinase domain-containing protein 10Disintegrin and metalloproteinase domain-containing protein 28
go.drugbank.com/bio_entities/BE0003872TargetHumansMay play a role in the adhesive and proteolytic events that occur during lymphocyte emigration or may function in ectodomain shedding of lymphocyte surface target proteins, such as FASL and CD40L.
Polypeptides: Disintegrin and metalloproteinase domain-containing protein 28Synonyms: Metalloproteinase-like, disintegrin-like, and cysteine-rich protein L, Epididymal metalloproteinase-like, disintegrin-like, and cysteine-rich protein IISodium- and chloride-dependent GABA transporter 2
go.drugbank.com/bio_entities/BE0004776TargetHumansCan also mediate transport of taurine and hypotaurine (By similarity) … Mediates sodium- and chloride-dependent transport of gamma-aminobutyric acid (GABA) (PubMed:17502375, PubMed:22932902). Mediates transport of beta-alanine (PubMed:17502375).
Polypeptides: Sodium- and chloride-dependent GABA transporter 2Calcium and integrin-binding family member 2
go.drugbank.com/bio_entities/BE0008698TargetHumansRequired for the maintenance of auditory hair cell stereocilia bundle morphology and function and for hair-cell survival in the cochlea (By similarity). … Critical for proper photoreceptor cell maintenance and function (By similarity).
Polypeptides: Calcium and integrin-binding family member 2Prothrombin
go.drugbank.com/bio_entities/BE0000048TargetEnzymeHumansActivates coagulation factor XI (F11); activation is promoted by the contact with negatively charged surfaces (PubMed:2019570, PubMed:21976677). … Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C.
Synonyms: Coagulation factor II