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Displaying results 141 - 150 of 2844 in total
  1. Pathway

    Mevalonic Aciduria

    smpdb.ca/view/SMP0000510
    Disease

    It is manifested by high levels of mevalonic acid in the urine and other body fluids. Approximately 30 patients with mevalonic aciduria (MVA) have been reported worldwide. … Mevalonic aciduria, also called MVA, is an extremely rare inherited inborn error of metabolism (IEM) and an autosomal recessive disorder caused by a defective mevalonate kinase gene.

    Drugs: Cholecalciferol · ATP · Magnesium cation · Iron · Dimethylallyl Diphosphate · Formic acid +8 more
    Enzymes: Lysosomal acid lipase/cholesteryl ester hydrolase
  2. Pathway

    Mevalonic Aciduria

    smpdb.ca/view/SMP0125643
    Disease

    It is manifested by high levels of mevalonic acid in the urine and other body fluids. Approximately 30 patients with mevalonic aciduria (MVA) have been reported worldwide. … Mevalonic aciduria, also called MVA, is an extremely rare inherited inborn error of metabolism (IEM) and an autosomal recessive disorder caused by a defective mevalonate kinase gene.

    Drugs: Cholecalciferol · ATP · Magnesium cation · Iron · Dimethylallyl Diphosphate · Formic acid +8 more
    Enzymes: Lysosomal acid lipase/cholesteryl ester hydrolase
  3. Pathway

    Fondaparinux.

    smpdb.ca/view/SMP0000273
    Drug action

    Then zooming in even further to the endoplasmic reticulum within the liver, vitamin K1 2,3-epoxide uses vitamin K epoxide reductase complex subunit 1 to become reduced vitamin K (phylloquinone), and then … back to vitamin K1 2,3-epoxide continually through vitamin K-dependent gamma-carboxylase.

    Drugs: Fondaparinux · Phylloquinone · Calcium
    Enzymes: Vitamin K-dependent gamma-carboxylase, Vitamin K epoxide reductase complex subunit 1
  4. Pathway

    Argatroban.

    smpdb.ca/view/SMP0000276
    Drug action

    Direct thrombin inhibitors bind plasma and fibrin bound thrombin independently of co-factor antithrombin.The inhibition of thrombin reduces the stability of the clot and promotes clot break down. … Argatroban does not effect serine proteases like, trypsin, factor Xa, plasmin, and kallikrein.

    Drugs: Argatroban · Phylloquinone · Calcium
    Enzymes: Vitamin K-dependent gamma-carboxylase, Vitamin K epoxide reductase complex subunit 1
  5. Pathway

    Risperidone Dopamine Antagonist Action Pathway

    smpdb.ca/view/SMP0126599
    Drug action

    Schizophrenia is thought to result from an excess of dopaminergic D2 and serotonergic 5-HT2A activity, resulting in overactivity of central mesolimbic pathways and mesocortical pathways, respectively. … While risperidone and 9-hydroxyrisperidone are often regarded as equipotent, they display different affinities towards the two target receptors (D2 and 5HT2A), where risperidone appears to be approximately

    Drugs: Pyridoxal phosphate · Tyrosine · Sapropterin · Risperidone · Dopamine · Levodopa +4 more
    Enzymes: Aromatic-L-amino-acid decarboxylase, D(2) dopamine receptor
  6. Pathway

    Phosphoenolpyruvate Carboxykinase Deficiency 1 (PEPCK1)

    smpdb.ca/view/SMP0000560
    Disease

    This disorder is characterized by a large accumulation of lactic acid in the blood. … Symptoms of the disorder include hepatomegaly, failure to thrive and liver failure, depending on the severity of the case. Treatment including heavy carbohydrates and fasting is very effective.

    Drugs: Pyruvic acid · Biotin · NADH · ATP · Magnesium cation · 2-phospho-D-glyceric acid +4 more
  7. Pathway

    Bromocriptine Mechanism of Action Action Pathway

    smpdb.ca/view/SMP0126674
    Drug action

    Inhibition of MAPK appears to be mediated by c-Raf and B-Raf-dependent inhibition of MAPK/ERK kinase. … Additionally, receptor activation blocks phosphorylation of p42/p44 MAPK and decreases MAPK/ERK kinase phosphorylation.

    Drugs: Pyridoxal phosphate · Tyrosine · Dopamine · Bromocriptine · Levodopa · Calcium +2 more
    Enzymes: Aromatic-L-amino-acid decarboxylase, D(2) dopamine receptor
  8. Pathway

    Acenocoumarol Action Pathway

    smpdb.ca/view/SMP0000269
    Drug action

    Vitamin K-dependent coagulation factors (II, VII, IX, and X) requires its cofactor, vitamin K to facilitate the activation and gamma-carboxylation. … Inhibition of vitamin K reductase results in reduced concentration of vitamin KH2, which will ultimately lead to decreased coagulability of the blood and reduced cleavage of fibrinogen into fibrin.

    Drugs: Phylloquinone · Calcium · Acenocoumarol
    Enzymes: Vitamin K-dependent gamma-carboxylase, Vitamin K epoxide reductase complex subunit 1
  9. Pathway

    Dicumarol Action Pathway

    smpdb.ca/view/SMP0000270
    Drug action

    Vitamin K-dependent coagulation factors (II, VII, IX, and X) requires its cofactor, vitamin K to facilitate the activation and gamma-carboxylation. … Inhibition of vitamin K reductase results in reduced concentration of vitamin KH2, which will ultimately lead to decreased coagulability of the blood and reduced cleavage of fibrinogen into fibrin.

    Drugs: Dicoumarol · Phylloquinone · Calcium
    Enzymes: Vitamin K-dependent gamma-carboxylase, Vitamin K epoxide reductase complex subunit 1
  10. Pathway

    Ximelagatran Action Pathway

    smpdb.ca/view/SMP0000279
    Drug action

    Then zooming in even further to the endoplasmic reticulum within the liver, vitamin K1 2,3-epoxide uses vitamin K epoxide reductase complex subunit 1 to become reduced vitamin K (phylloquinone), and then … back to vitamin K1 2,3-epoxide continually through vitamin K-dependent gamma-carboxylase.

    Drugs: Phylloquinone · Calcium · Ximelagatran
    Enzymes: Vitamin K-dependent gamma-carboxylase, Vitamin K epoxide reductase complex subunit 1