Search

Displaying results 141 - 150 of 184 in total
  1. Target

    Metallo-beta-lactamase type 2

    go.drugbank.com/bio_entities/BE0001212
    TargetEnzymeBacteroides fragilis

    Confers resistance to the different beta-lactams antibiotics (penicillin, cephalosporin and carbapenem) via the hydrolysis of the beta-lactam ring.

    Synonyms: Carbapenem and cephamycin resistance
  2. Target

    Protein O-GlcNAcase

    go.drugbank.com/bio_entities/BE0005827
    TargetHumans

    Deglycosylates a large and diverse number of proteins, such as CRYAB, ELK1, GSDMD, LMNB1 and TAB1 (PubMed:28939839, PubMed:37962578). … Does not bind acetyl-CoA and does not have histone acetyltransferase activity (PubMed:24088714)

    Synonyms: Nuclear cytoplasmic O-GlcNAcase and acetyltransferase
  3. Target

    Angiopoietin-1 receptor

    go.drugbank.com/bio_entities/BE0003379
    TargetHumans

    and of the downstream kinases MAPK1/ERK2 and MAPK3/ERK1, and ultimately to the stimulation of sprouting angiogenesis. … In quiescent vessels, ANGPT1 oligomers recruit TEK to cell-cell contacts, forming complexes with TEK molecules from adjoining cells, and this leads to preferential activation of phosphatidylinositol 3-

    Synonyms: Tyrosine kinase with Ig and EGF homology domains-2
  4. Target

    Metal cation symporter ZIP8

    go.drugbank.com/bio_entities/BE0009901
    TransporterHumans

    Thereby, it also contributes to the cellular uptake of selenium, an essential trace metal and micronutrient (PubMed:27166256). … By regulating zinc influx into monocytes also directly modulates their adhesion to endothelial cells and arteries (By similarity).

    Synonyms: Zrt- and Irt-like protein 8
  5. Target

    Cyclic nucleotide phosphodiesterase

    go.drugbank.com/bio_entities/BE0004922
    TargetHumans

    Catalyzes the hydrolysis of both cAMP and cGMP to 5'-AMP and 5'-GMP, respectively (PubMed:10725373, PubMed:10906126, PubMed:11050148) … Modulates the amplitude and duration of the cAMP signal in sensory cilia in response to odorant stimulation, hence contributing to the generation of action potentials.

    Polypeptides: Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A, cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10ASynonyms: cAMP and cGMP phosphodiesterase 11A
  6. Target

    Serine/threonine-protein kinase TAO1

    go.drugbank.com/bio_entities/BE0009392
    TargetHumans

    Acts as a regulator of cytoskeleton stability by phosphorylating 'Thr-208' of MARK2, leading to activate MARK2 kinase activity and subsequent phosphorylation and detachment of MAPT/TAU from microtubules … In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of MAP2K3 and MAP2K6.

    Synonyms: Thousand and one amino acid protein kinase 1
  7. Target

    TIR domain-containing adapter molecule 1

    go.drugbank.com/bio_entities/BE0016552
    TargetHumans

    Adapter used by TLR3, TLR4 (through TICAM2) and TLR5 to mediate NF-kappa-B and interferon-regulatory factor (IRF) activation, and to induce apoptosis (PubMed:12471095, PubMed:12539043, PubMed:14739303, … Phosphorylation by TBK1 on the pLxIS motif leads to recruitment and subsequent activation of the transcription factor IRF3 to induce expression of type I interferon and exert a potent immunity against

    Synonyms: Proline-rich, vinculin and TIR domain-containing protein B
  8. Target

    E3 ubiquitin-protein ligase UHRF1

    go.drugbank.com/bio_entities/BE0018559
    TargetHumans

    Also localizes to euchromatic regions where it negatively regulates transcription possibly by impacting DNA methylation and histone modifications (PubMed:21777816). … Acts both as a histone reader and writer: specifically recognizes and binds (1) hemimethylated DNA at replication forks and (2) histone H3 trimethylated at 'Lys-9' and unmethylated at 'Arg-2' (H3K9me3

    Synonyms: Ubiquitin-like PHD and RING finger domain-containing protein 1
  9. Target

    Serine/threonine-protein kinase mTOR

    go.drugbank.com/bio_entities/BE0002386
    TargetHumans

    In response to nutrients, growth factors or amino acids, mTORC1 is recruited to the lysosome membrane and promotes protein, lipid and nucleotide synthesis by phosphorylating key regulators of mRNA translation … In response to growth factors, mTORC2 phosphorylates and activates AGC protein kinase family members, including AKT (AKT1, AKT2 and AKT3), PKC (PRKCA, PRKCB and PRKCE) and SGK1 (PubMed:15268862, PubMed

    Synonyms: Rapamycin and FKBP12 target 1
  10. Target

    Serine/threonine-protein kinase TAO3

    go.drugbank.com/bio_entities/BE0009393
    TargetHumans

    Inhibits basal activity of the MAPK8/JNK cascade and diminishes its activation in response to epidermal growth factor (EGF). … Phosphorylates PTPN6/SHP1 on 'Thr-394', leading to its polyubiquitination and subsequent proteasomal degradation (PubMed:38166031).

    Synonyms: Thousand and one amino acid protein 3