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Displaying results 141 - 150 of 1567 in total
  1. Pathway

    Famotidine H2 Anti-Histamine Action Pathway

    smpdb.ca/view/SMP0126789
    Drug action

    This blocks the downstream Gs cascade which produces cyclic adenosine monophosphate (cAMP) which is an activator for the potassium-hydrogen ATPase pump (H+/K+ ATPase pump).

    Drugs: ATP · Famotidine · Potassium cation · Magnesium cation · Zinc · Cyclic adenosine monophosphate
    Enzymes: Chloride anion exchanger, Potassium-transporting ATPase alpha chain 1
  2. Pathway

    Rabeprazole Metabolism Pathway

    smpdb.ca/view/SMP0000616
    Drug metabolism

    A chloride ion is transported into the gastric endothelial cell through a chloride anion exchanger and is transported out of the cell through a chloride intracellular channel protein 2, back into the gastric … The potassium transporting ATPase also converts water and ATP to a phosphate molecule and ADP. Alongside the transporters, potassium is brought into the cell.

    Drugs: Rabeprazole
    Enzymes: Potassium-transporting ATPase alpha chain 1, Potassium-transporting ATPase subunit beta
  3. Pathway

    Ranolazine Action Pathway

    smpdb.ca/view/SMP0126279
    Drug action

    Electrolyte balance of sodium and potassium is necessary for maintaining normal cardiac contraction and relaxation. … Disruption of adequate sodium and potassium electrolyte balance leads to excessively high concentrations of sodium and calcium, which likely interferes with oxygen supply to the heart muscle.

    Drugs: Ranolazine · Potassium cation · Calcium · Cyclic adenosine monophosphate
    Enzymes: Potassium channel subfamily K member 1, Inward rectifier potassium channel 4
  4. Pathway

    Disopyramide Cardiac Action Pathway

    smpdb.ca/view/SMP0126247
    Drug action

    Disopyramide is a class 1A antiarrhythmic agent used to treat life-threatening ventricular arrhythmias. It can be found under the brand names Norpace and Rythmodan. A class I anti-arrhythmic agent (one that interferes directly with the d...

    Drugs: Disopyramide · Potassium cation · Calcium · Cyclic adenosine monophosphate
    Enzymes: Potassium channel subfamily K member 1, Inward rectifier potassium channel 4
  5. Pathway

    Mexiletine Action Pathway (New)

    smpdb.ca/view/SMP0126263
    Drug action

    Mexiletine is a class 1B antiarrhythmic agent used in the treatment of documented ventricular arrhythmias that warrant treatment. Mexiletine (INN) (sold under the brand names Mexitil and Namuscla) is a medication used to treat abnormal h...

    Drugs: Mexiletine · Potassium cation · Calcium · Cyclic adenosine monophosphate
    Enzymes: Potassium channel subfamily K member 1, Inward rectifier potassium channel 4
  6. Pathway

    Moricizine Action Pathway

    smpdb.ca/view/SMP0126950
    Drug action

    Moricizine is an antiarrhythmic used to treat arrhythmias (irregular heartbeats) and to maintain normal heart rate. it acts on heart muscles by inhibiting inward sodium channels. This results in a slowed atrioventricular nodal and His-Pu...

    Drugs: Moricizine · Potassium cation · Calcium · Cyclic adenosine monophosphate
    Enzymes: Potassium channel subfamily K member 1, Inward rectifier potassium channel 4
  7. Pathway

    Phenytoin (Antiarrhythmic) Action Pathway

    smpdb.ca/view/SMP0000327
    Drug action

    potassium channel (I-Kur) open. … At rest, the cardiac cell membrane is impermeable to sodium and calcium ions, but is permeable to potassium ions via inward rectifier potassium channels (I-K1), which allow an outward flow of potassium

    Drugs: Ademetionine · ATP · Phenytoin · Potassium cation · Calcium · Magnesium cation +3 more
    Enzymes: Potassium channel subfamily K member 1, Inward rectifier potassium channel 4
  8. Pathway

    Lidocaine Sodium Channel Cardiac Muscle Relaxation Action Pathway

    smpdb.ca/view/SMP0126504
    Drug action

    Lidocaine is a local anesthetic used in a wide variety of superficial and invasive procedures. It can be found under the brand names Agoneaze, Akten, Alivio, Anestacon, Anodyne Lpt, Astero, Band-aid Hurt-free, Cathejell, Curacaine, Depo-...

    Drugs: Lidocaine · Potassium cation · Calcium · Cyclic adenosine monophosphate
    Enzymes: Potassium channel subfamily K member 1, Inward rectifier potassium channel 4
  9. Pathway

    Codeine Action Pathway

    smpdb.ca/view/SMP0000405
    Drug action

    Opioids close N-type voltage-operated calcium channels (OP2-receptor agonist) and open calcium-dependent inwardly rectifying potassium channels (OP3 and OP1 receptor agonist).

    Drugs: NADH · ATP · Morphine · Codeine · Norepinephrine · Dopamine +5 more
    Enzymes: Sodium/potassium-transporting ATPase subunit alpha-1, Sodium/potassium-transporting ATPase subunit beta-1
  10. Pathway

    Oxymorphone Action Pathway

    smpdb.ca/view/SMP0000412
    Drug action

    Hyperpolarization of neuron is caused by inactivation of calcium channels and activation of potassium channels via facilitated by G-protein.

    Drugs: ATP · Norepinephrine · Dopamine · Oxymorphone · Potassium cation · Calcium
    Enzymes: Sodium/potassium-transporting ATPase subunit alpha-1, Sodium/potassium-transporting ATPase subunit beta-1