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Glutathione Metabolism
smpdb.ca/view/SMP0000015MetabolicGlutathione (GSH) is an low-molecular-weight thiol and antioxidant in various species such as plants, mammals and microbes. Glutathione plays important roles in nutrient metabolism, gene expression, etc. and sufficient protein nutrition ...
Enzymes: Mitochondrial 2-oxoglutarate/malate carrier protein5-Oxoprolinase Deficiency
smpdb.ca/view/SMP0000500Disease5-Oxoprolinase deficiency, also called OPLAHD, is a rare inborn error of metabolism (IEM) and autosomal recessive disorder of glutathione metabolism caused by a defective 5-oxoprolinase. 5-Oxoprolinase catalyzes the conversion of 5-oxopr...
Enzymes: Mitochondrial 2-oxoglutarate/malate carrier proteingamma-Glutamyltranspeptidase Deficiency
smpdb.ca/view/SMP0000501DiseaseGamma-glutamyltranspeptidase deficiency, characterized by glutathionemia and glutathionuria, is an autosomal recessive disorder of glutathione metabolism caused by a defective gamma-glutamyl transpeptidase (GGT). GGT transfers glutamyl m...
Enzymes: Mitochondrial 2-oxoglutarate/malate carrier proteinGlutathione Synthetase Deficiency
smpdb.ca/view/SMP0125614DiseaseGlutathione Synthetase Deficiency (5-Oxoprolinuria; Pyroglutamic Aciduria; GSD) is a rare inborn error of metabolism (IEM) which arises from a disfunctional gene called GSS. This gene is responsible for glutathione synthetase. Glutathion...
Enzymes: Mitochondrial 2-oxoglutarate/malate carrier proteingamma-Glutamyltransferase Deficiency
smpdb.ca/view/SMP0125616DiseaseGamma-Glutamyltransferase Deficiency is an autosomal recessive disorder caused by a mutation in the GGT1 gene which codes for gamma-glutamyltranspeptidase 1. A deficiency in this enzyme results in accumulation of L-cysteine, gamma-glutam...
Enzymes: Mitochondrial 2-oxoglutarate/malate carrier protein5-Oxoprolinase Deficiency
smpdb.ca/view/SMP0125617Disease5-Oxoprolinase deficiency, also called OPLAHD, is a rare inborn error of metabolism (IEM) and autosomal recessive disorder of glutathione metabolism caused by a defective 5-oxoprolinase. 5-Oxoprolinase catalyzes the conversion of 5-oxopr...
Enzymes: Mitochondrial 2-oxoglutarate/malate carrier proteinDorzolamide
go.drugbank.com/drugs/DB00869ApprovedInvestigationalDorzolamide is a non-bacteriostatic sulfonamide derivative and topical carbonic anhydrase (CA) inhibitor that treats elevated intraocular pressure (IOP) associated with open-angle glaucoma and ocular hypertension. It works by blocking an...
Mixtures: Dorzolamide HCl /Timolol Maleate, Dorzolamide HCl and Timolol MaleateIrsogladine
go.drugbank.com/drugs/DB13056InvestigationalIrsogladine is under investigation in clinical trial NCT02581696 (The Drug-drug Interaction and Safety of Lafutidine and Irsogladine Maleate in Healthy Adult Volunteers).
Acute Migraine
go.drugbank.com/conditions/DBCOND0043723