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Displaying results 151 - 160 of 485 in total
  1. Target

    Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide

    go.drugbank.com/bio_entities/BE0001300
    TargetHumans

    May act as a B-cell-associated adapter that regulates B-cell antigen receptor (BCR)-signaling downstream of PI3K

    Polypeptides: Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide
  2. Target

    Gamma-aminobutyric acid type B receptor subunit 2

    go.drugbank.com/bio_entities/BE0002340
    TargetHumans

    Component of a heterodimeric G protein-coupled receptor for GABA, formed by GABBR1 and GABBR2 (PubMed:15617512, PubMed:18165688, PubMed:22660477, PubMed:24305054, PubMed:9872316, PubMed:9872744). … Within the heterodimeric GABA receptor, only GABBR1 seems to bind agonists, while GABBR2 mediates coupling to G proteins (PubMed:18165688).

    Polypeptides: Gamma-aminobutyric acid type B receptor subunit 2
  3. Target

    Gamma-aminobutyric acid type B receptor subunit 1

    go.drugbank.com/bio_entities/BE0000217
    TargetHumans

    Component of a heterodimeric G protein-coupled receptor for GABA, formed by GABBR1 and GABBR2 (PubMed:15617512, PubMed:18165688, PubMed:22660477, PubMed:24305054, PubMed:36103875, PubMed:9872316, PubMed … Within the heterodimeric GABA receptor, only GABBR1 seems to bind agonists, while GABBR2 mediates coupling to G proteins (PubMed:18165688).

    Polypeptides: Gamma-aminobutyric acid type B receptor subunit 1
  4. Target

    N-acetylneuraminic acid outer membrane channel protein NanC

    go.drugbank.com/bio_entities/BE0004175
    TargetEscherichia coli (strain K12)

    NanC proteins form high-conductance channels which are open at low membrane potentials and which have a weak anion selectivity (PubMed:15743943). … Outer membrane channel protein allowing the entry of N-acetylneuraminic acid (Neu5Ac, the most abundant sialic acid on host cell surfaces) into the bacteria (PubMed:15743943, PubMed:22246445).

    Polypeptides: N-acetylneuraminic acid outer membrane channel protein NanCSynonyms: N-acetylneuraminic acid-inducible outer membrane channel, Probable N-acetylneuraminic acid outer membrane channel protein NanC
  5. Target

    Sodium-dependent neutral amino acid transporter B(0)AT1

    go.drugbank.com/bio_entities/BE0015577
    TransporterTargetHumans

    Requires CLTRN in kidney or ACE2 in intestine for cell surface expression and amino acid transporter activity (PubMed:18424768, PubMed:19185582) … Transporter that mediates resorption of neutral amino acids across the apical membrane of renal and intestinal epithelial cells (PubMed:15286787, PubMed:15286788, PubMed:18424768, PubMed:18484095, PubMed

    Polypeptides: Sodium-dependent neutral amino acid transporter B(0)AT1Synonyms: System B(0) neutral amino acid transporter AT1
  6. Target

    B- and T-lymphocyte attenuator

    go.drugbank.com/bio_entities/BE0010629
    TargetHumans

    In cis interactions, appears to play an immune regulatory role inhibiting in trans interactions in naive T cells to maintain a resting state. … Inhibitory receptor on lymphocytes that negatively regulates antigen receptor signaling via PTPN6/SHP-1 and PTPN11/SHP-2 (PubMed:12796776, PubMed:14652006, PubMed:15568026, PubMed:18193050).

    Polypeptides: B- and T-lymphocyte attenuatorSynonyms: B- and T-lymphocyte-associated protein
  7. Target

    Insulin-like growth factor-binding protein complex acid labile subunit

    go.drugbank.com/bio_entities/BE0009058
    TargetCarrierHumans

    Involved in protein-protein interactions that result in protein complexes, receptor-ligand binding or cell adhesion

    Polypeptides: Insulin-like growth factor-binding protein complex acid labile subunit
  8. Target

    Splicing factor, proline- and glutamine-rich

    go.drugbank.com/bio_entities/BE0008965
    TargetHumans

    During splicing of PTPRC/CD45, a phosphorylated form is sequestered by THRAP3 from the pre-mRNA in resting T-cells; T-cell activation and subsequent reduced phosphorylation is proposed to lead to release … The SFPQ-NONO-NR5A1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional activity.

    Polypeptides: Splicing factor, proline- and glutamine-rich
  9. Target

    Cocaine- and amphetamine-regulated transcript protein

    go.drugbank.com/bio_entities/BE0000867
    TargetHumans

    Satiety factor closely associated with the actions of leptin and neuropeptide Y; this anorectic peptide inhibits both normal and starvation-induced feeding and completely blocks the feeding response induced … It promotes neuronal development and survival in vitro

    Polypeptides: Cocaine- and amphetamine-regulated transcript protein
  10. Target

    Multidrug and toxin extrusion protein 1

    go.drugbank.com/bio_entities/BE0003657
    TransporterTargetHumans

    Plays a physiological role in the excretion of cationic compounds including endogenous metabolites, drugs, toxins through the kidney and liver, into urine and bile respectively (PubMed:16330770, PubMed … May also contribute to regulate the transport of cationic compounds in testis across the blood-testis-barrier (Probable)

    Polypeptides: Multidrug and toxin extrusion protein 1