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Aurora kinase B
go.drugbank.com/bio_entities/BE0003404TargetHumansThe CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly ( … histone H2A and enhancing binding and activity of the USP16 deubiquitinase at transcribed genes (By similarity).
Synonyms: Aurora- and IPL1-like midbody-associated protein 1Aurora kinase A
go.drugbank.com/bio_entities/BE0000991TargetHumansRequired for normal spindle positioning during mitosis and for the localization of NUMA1 and DCTN1 to the cell cortex during metaphase (PubMed:27335426). … Associates with the centrosome and the spindle microtubules during mitosis and plays a critical role in various mitotic events including the establishment of mitotic spindle, centrosome duplication, centrosome
Synonyms: Ipl1- and aurora-related kinase 1E3 ubiquitin-protein ligase HUWE1
go.drugbank.com/bio_entities/BE0016469TargetHumansRegulates neural differentiation and proliferation by catalyzing the polyubiquitination and degradation of MYCN (PubMed:18488021). … Also ubiquitinates the p53/TP53 tumor suppressor and core histones including H1, H2A, H2B, H3 and H4 (PubMed:15567145, PubMed:15767685, PubMed:15989956).
Synonyms: HECT, UBA and WWE domain-containing protein 1NADPH oxidase
go.drugbank.com/bio_entities/BE0004904TargetHumansefficiency in chemokine uptake and degradation. … Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. Stimulates PKN2 kinase activity (PubMed:9121475).
Synonyms: SH3 and PX domain-containing protein 1A, SH3 and PX domain-containing protein 4Surfactant protein C
go.drugbank.com/bio_entities/BE0012617TargetHumansPulmonary surfactant associated proteins promote alveolar stability by lowering the surface tension at the air-liquid interface in the peripheral air spaces
Synonyms: Pulmonary surfactant-associated protein C, Pulmonary surfactant-associated proteolipid SPL(Val)Angiopoietin-2
go.drugbank.com/bio_entities/BE0010028TargetHumansBinds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating ANGPT1 signaling (PubMed:15284220, PubMed:19116766, PubMed:19223473, PubMed:9204896). … In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal (PubMed:15284220, PubMed:19116766, PubMed:19223473, PubMed:9204896).
Synonyms: ANG-2Angiopoietin-1
go.drugbank.com/bio_entities/BE0010681TargetHumansBinds and activates TEK/TIE2 receptor by inducing its dimerization and tyrosine phosphorylation. … kinase and the AKT1 signaling cascades.
Synonyms: ANG-1Aminoglycoside nucleotidyltransferase (4')
go.drugbank.com/bio_entities/BE0003547EnzymeStaphylococcus aureusInactivates the antibiotic kanamycin by catalyzing the transfer of a nucleotidyl group from nucleoside triphosphates such as ATP to the 4'-hydroxyl group of the aminoglycoside.
Synonyms: ANT(4')Angiopoietin-related protein 3
go.drugbank.com/bio_entities/BE0010034TargetHumansThe inhibition of LPL activity appears to be an indirect mechanism involving recruitment of proprotein convertases PCSK6 and FURIN to LPL leading to cleavage and dissociation of LPL from the cell surface … Can bind to adipocytes to activate lipolysis, releasing free fatty acids and glycerol (PubMed:12565906).
Synonyms: ANG-5Natriuretic peptides B
go.drugbank.com/bio_entities/BE0000979TargetHumansInvolved in regulating the extracellular fluid volume and maintaining the fluid-electrolyte balance through natriuresis, diuresis, vasorelaxation, and inhibition of renin and aldosterone secretion (PubMed … Acts by specifically binding and stimulating NPR1 to produce cGMP, which in turn activates effector proteins that drive various biological responses (PubMed:1672777, PubMed:17349887, PubMed:17372040, PubMed
Synonyms: Iso-ANP