Search
Angiopoietin-1 receptor
go.drugbank.com/bio_entities/BE0003379TargetHumansTyrosine-protein kinase that acts as a cell-surface receptor for ANGPT1, ANGPT2 and ANGPT4 and regulates angiogenesis, endothelial cell survival, proliferation, migration, adhesion and cell spreading, … kinase and the AKT1 signaling cascades.
Synonyms: Tyrosine kinase with Ig and EGF homology domains-2Metal cation symporter ZIP8
go.drugbank.com/bio_entities/BE0009901TransporterHumansTransports an electroneutral complex composed of a divalent metal cation and two bicarbonate anions or alternatively a bicarbonate and a selenite anion (PubMed:27166256, PubMed:31699897). … Thereby, it also contributes to the cellular uptake of selenium, an essential trace metal and micronutrient (PubMed:27166256).
Synonyms: Zrt- and Irt-like protein 8Cyclic nucleotide phosphodiesterase
go.drugbank.com/bio_entities/BE0004922TargetHumansCatalyzes the hydrolysis of both cAMP and cGMP to 5'-AMP and 5'-GMP, respectively (PubMed:10725373, PubMed:10906126, PubMed:11050148) … The PDE6 holoenzyme consists of two catalytic subunits (PDE6A and PDE6B) and two inhibitory gamma subunits (PDE6G) (PubMed:20940301).
Polypeptides: Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A, cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10ASynonyms: cAMP and cGMP phosphodiesterase 11ASerine/threonine-protein kinase TAO1
go.drugbank.com/bio_entities/BE0009392TargetHumansPhosphorylates MAP2K3, MAP2K6 and MARK2. … Acts as an activator of the p38/MAPK14 stress-activated MAPK cascade by mediating phosphorylation and subsequent activation of the upstream MAP2K3 and MAP2K6 kinases.
Synonyms: Thousand and one amino acid protein kinase 1TIR domain-containing adapter molecule 1
go.drugbank.com/bio_entities/BE0016552TargetHumansAdapter used by TLR3, TLR4 (through TICAM2) and TLR5 to mediate NF-kappa-B and interferon-regulatory factor (IRF) activation, and to induce apoptosis (PubMed:12471095, PubMed:12539043, PubMed:14739303, … Distinct protein-interaction motifs allow recruitment of the effector proteins TBK1, TRAF6 and RIPK1, which in turn, lead to the activation of transcription factors IRF3 and IRF7, NF-kappa-B and FADD respectively
Synonyms: Proline-rich, vinculin and TIR domain-containing protein BE3 ubiquitin-protein ligase UHRF1
go.drugbank.com/bio_entities/BE0018559TargetHumansActs both as a histone reader and writer: specifically recognizes and binds (1) hemimethylated DNA at replication forks and (2) histone H3 trimethylated at 'Lys-9' and unmethylated at 'Arg-2' (H3K9me3 … Also mediates histone H3 'Lys-14' and 'Lys-23' ubiquitination (H3K14ub and H3K23ub) at lower level (PubMed:24013172, PubMed:27595565).
Synonyms: Ubiquitin-like PHD and RING finger domain-containing protein 1Serine/threonine-protein kinase mTOR
go.drugbank.com/bio_entities/BE0002386TargetHumansIn response to growth factors, mTORC2 phosphorylates and activates AGC protein kinase family members, including AKT (AKT1, AKT2 and AKT3), PKC (PRKCA, PRKCB and PRKCE) and SGK1 (PubMed:15268862, PubMed … Functions as part of 2 structurally and functionally distinct signaling complexes mTORC1 and mTORC2 (mTOR complex 1 and 2) (PubMed:15268862, PubMed:15467718, PubMed:18497260, PubMed:18925875, PubMed:20516213
Synonyms: Rapamycin and FKBP12 target 1Serine/threonine-protein kinase TAO3
go.drugbank.com/bio_entities/BE0009393TargetHumansPromotes JNK signaling in hepatocytes and positively regulates hepatocyte lipid storage by inhibiting beta-oxidation and triacylglycerol secretion while enhancing lipid synthesis (PubMed:34634521). … Serine/threonine-protein kinase that acts as a regulator of the p38/MAPK14 stress-activated MAPK cascade and of the MAPK8/JNK cascade.
Synonyms: Thousand and one amino acid protein 3Alpha-ketoglutarate-dependent dioxygenase FTO
go.drugbank.com/bio_entities/BE0005795TargetHumansRNA demethylase that mediates oxidative demethylation of different RNA species, such as mRNAs, tRNAs and snRNAs, and acts as a regulator of fat mass, adipogenesis and energy homeostasis (PubMed:22002720 … Involved in the regulation of fat mass, adipogenesis and body weight, thereby contributing to the regulation of body size and body fat accumulation (PubMed:18775698, PubMed:20376003).
Synonyms: Fat mass and obesity-associated proteinAurora kinase B
go.drugbank.com/bio_entities/BE0003404TargetHumansThe CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly ( … histone H2A and enhancing binding and activity of the USP16 deubiquitinase at transcribed genes (By similarity).
Synonyms: Aurora- and IPL1-like midbody-associated protein 1