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Alpha-ketoglutarate-dependent dioxygenase FTO
go.drugbank.com/bio_entities/BE0005795TargetHumansASB2 and RARA, leading to promote their expression (PubMed:28017614, PubMed:29249359) … Ability to repair alkylated DNA and RNA is however unsure in vivo (PubMed:18775698, PubMed:20376003).
Synonyms: Fat mass and obesity-associated proteinE3 ubiquitin-protein ligase HUWE1
go.drugbank.com/bio_entities/BE0016469TargetHumansBinds to an upstream initiator-like sequence in the preprodynorphin gene (By similarity). … Acts in concert with MYCBP2 to regulate the circadian clock gene expression by promoting the lithium-induced ubiquitination and degradation of NR1D1 (PubMed:20534529).
Synonyms: HECT, UBA and WWE domain-containing protein 1, Homologous to E6AP carboxyl terminus homologous protein 9Aurora kinase B
go.drugbank.com/bio_entities/BE0003404TargetHumansA positive feedback loop involving HASPIN and AURKB contributes to localization of CPC to centromeres (PubMed:21658950). … Key component of the cytokinesis checkpoint, a process required to delay abscission to prevent both premature resolution of intercellular chromosome bridges and accumulation of DNA damage: phosphorylates
Synonyms: Aurora- and IPL1-like midbody-associated protein 1Aurora kinase A
go.drugbank.com/bio_entities/BE0000991TargetHumansRequired for normal spindle positioning during mitosis and for the localization of NUMA1 and DCTN1 to the cell cortex during metaphase (PubMed:27335426). … Associates with the centrosome and the spindle microtubules during mitosis and plays a critical role in various mitotic events including the establishment of mitotic spindle, centrosome duplication, centrosome
Synonyms: Ipl1- and aurora-related kinase 1NADPH oxidase
go.drugbank.com/bio_entities/BE0004904TargetHumansIn its active state, binds to a variety of effector proteins to regulate cellular responses, such as secretory processes, phagocytose of apoptotic cells and epithelial cell polarization. … In the activated complex, electrons are first transferred from NADPH to flavin adenine dinucleotide (FAD) and subsequently transferred via two heme molecules to molecular oxygen, producing superoxide through
Synonyms: SH3 and PX domain-containing protein 4, SH3 and PX domain-containing protein 1AMolybdenum cofactor biosynthesis protein 1
go.drugbank.com/bio_entities/BE0011005TargetHumansMOCS1A catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate and MOCS1B catalyzes the subsequent conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to … Isoform MOCS1A and isoform MOCS1B probably form a complex that catalyzes the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP) (PubMed:11891227, PubMed:23627491, PubMed:29368224, PubMed:
Synonyms: Molybdenum cofactor synthesis-step 1 protein A-BSulfotransferase 1E1
go.drugbank.com/bio_entities/BE0000951TargetEnzymeHumansSulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of estradiol and estrone (PubMed:11006110, PubMed:11884392, PubMed:7779757). … Is a key enzyme in estrogen homeostasis, the sulfation of estrogens leads to their inactivation.
Synonyms: STEDNA topoisomerase 2-alpha
go.drugbank.com/bio_entities/BE0000742TargetHumansstrand, and religating the broken strand (PubMed:17567603, PubMed:18790802, PubMed:22013166, PubMed:22323612, PubMed:27754753). … Key decatenating enzyme that alters DNA topology by binding to two double-stranded DNA molecules, generating a double-stranded break in one of the strands, passing the intact strand through the broken
Synonyms: TOP2STE20/SPS1-related proline-alanine-rich protein kinase
go.drugbank.com/bio_entities/BE0009391TargetHumansMediates regulatory volume increase in response to hyperosmotic stress by catalyzing phosphorylation of ion cotransporters SLC12A1/NKCC2, SLC12A2/NKCC1 and SLC12A6/KCC3 downstream of WNK1 and WNK3 kinases … Effector serine/threonine-protein kinase component of the WNK-SPAK/OSR1 kinase cascade, which is involved in various processes, such as ion transport, response to hypertonic stress and blood pressure (
Synonyms: Ste-20-related kinasePresenilin-2
go.drugbank.com/bio_entities/BE0011014TargetHumansThe holoprotein functions as a calcium-leak channel that allows the passive movement of calcium from endoplasmic reticulum to cytosol and is involved in calcium homeostasis (PubMed:16959576). … Is a regulator of mitochondrion-endoplasmic reticulum membrane tethering and modulates calcium ions shuttling between ER and mitochondria (PubMed:21285369)
Synonyms: STM-2