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Aklanonic acid methyl ester cyclase AcmA
go.drugbank.com/bio_entities/BE0003340TargetStreptomyces galilaeus, aclacinomycin T (aklavin) and aclacinomycin A (aclarubicin). … These compounds are aromatic polyketide antibiotics that exhibit high cytotoxicity and are widely applied in the chemotherapy of a variety of cancers.
Polypeptides: Aklanonic acid methyl ester cyclase AcmAGamma-aminobutyric acid receptor subunit epsilon
go.drugbank.com/bio_entities/BE0003595TargetHumansGABA-gated chloride channels, also named GABA(A) receptors (GABAAR), consist of five subunits arranged around a central pore and contain GABA active binding site(s) located at the alpha and beta subunit … Epsilon subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain (PubMed:16412217, PubMed:9882711).
Polypeptides: Gamma-aminobutyric acid receptor subunit epsilonSodium-coupled neutral amino acid transporters
go.drugbank.com/bio_entities/BE0009976TargetHumansAlso mediates an amino acid-gated H(+) conductance that is not stoichiometrically coupled to the amino acid transport but which influences the ionic gradients that drive the amino acid transport (By similarity … In addition, may play a role in nitrogen metabolism, amino acid homeostasis, glucose metabolism and renal ammoniagenesis (By similarity)
Polypeptides: Sodium-coupled neutral amino acid symporter 1, Sodium-coupled neutral amino acid symporter 2Synonyms: Amino acid transporter A1, Amino acid transporter A25,6-dihydroxyindole-2-carboxylic acid oxidase
go.drugbank.com/bio_entities/BE0010503TargetHumansAlso to a lower extent, capable of hydroxylating tyrosine and producing melanin (By similarity) … Catalyzes the oxidation of 5,6-dihydroxyindole-2-carboxylic acid (DHICA) into indole-5,6-quinone-2-carboxylic acid in the presence of bound Cu(2+) ions, but not in the presence of Zn(2+) (PubMed:28661582
Polypeptides: 5,6-dihydroxyindole-2-carboxylic acid oxidaseBranched-chain-amino-acid aminotransferase, mitochondrial
go.drugbank.com/bio_entities/BE0000721TargetHumansMechanistically, acetyl-CoA derived from branched chain amino acid catabolism is used by EP300/p300 to acetylate and inhibit PRDM16, thereby preventing adipose tissue browning (By similarity). … Catalyzes the first reaction in the catabolism of the essential branched chain amino acids leucine, isoleucine, and valine (PubMed:17050531, PubMed:25653144, PubMed:8702755).
Polypeptides: Branched-chain-amino-acid aminotransferase, mitochondrialFunction: branched-chain-amino-acidAmino acid transporter heavy chain SLC3A1
go.drugbank.com/bio_entities/BE0001130TransporterHumansSLC7A9-SLC3A1 transporter has system b(0,+)-like activity with high affinity for extracellular cationic amino acids and L-cystine and lower affinity for intracellular neutral amino acids. … Associates with SLC7A9 to form a functional transporter complex that mediates the electrogenic exchange between cationic amino acids and neutral amino acids, with a stoichiometry of 1:1.
Polypeptides: Amino acid transporter heavy chain SLC3A1Synonyms: Neutral and basic amino acid transport protein, b(0,+)-type amino acid transporter-related heavy chainN-carbamoyl-D-amino acid hydrolase
go.drugbank.com/bio_entities/BE0001323TargetAgrobacterium sp. (strain KNK712)The enzyme catalyzes the hydrolysis of N-carbamoyl-D-amino acids to the corresponding which are useful intermediates in the preparation of beta-lactam antibiotics.
Polypeptides: N-carbamoyl-D-amino acid hydrolasePeptidoglycan-N-acetylmuramic acid deacetylase PdaA
go.drugbank.com/bio_entities/BE0001989TargetBacillus subtilis (strain 168)PdaA probably carries out both deacetylation and lactam ring formation and requires the product of CwlD activity on peptidoglycan as a substrate. Is required for germination. … of deacetylated muramic acid residues.
Polypeptides: Peptidoglycan-N-acetylmuramic acid deacetylase PdaAGamma-aminobutyric acid receptor subunit pi
go.drugbank.com/bio_entities/BE0003596TargetHumansGABA-gated chloride channels, also named GABA(A) receptors (GABAAR), consist of five subunits arranged around a central pore and contain GABA active binding site(s) located at the alpha and beta subunit … Pi subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA) (PubMed:10462548).
Polypeptides: Gamma-aminobutyric acid receptor subunit pi1-deoxypentalenic acid 11-beta-hydroxylase
go.drugbank.com/bio_entities/BE0003748TargetStreptomyces avermitilis (strain ATCC 31267 / DSM 46492 / JCM 5070 / NCIMB 12804 / NRRL 8165 / MA-4680)Catalyzes the conversion of 1-deoxypentalenic acid to 11-beta-hydroxy-1-deoxypentalenic acid in the biosynthesis of neopentalenolactone antibiotic.
Polypeptides: 1-deoxypentalenic acid 11-beta-hydroxylase