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Acid-sensing ion channel 3
go.drugbank.com/bio_entities/BE0004768TargetHumansDisplays high selectivity for sodium ions but can also permit the permeation of other cations (PubMed:9744806, PubMed:9886053). … Forms pH-gated heterotrimeric sodium channels that act as postsynaptic excitatory receptors in the nervous system (PubMed:10842183, PubMed:11587714, PubMed:9744806, PubMed:9886053).
Synonyms: Testis sodium channel 1Propionyl-CoA carboxylase beta chain, mitochondrial
go.drugbank.com/bio_entities/BE0000544TargetEnzymeHumansvaline and other metabolites (PubMed:15890657, PubMed:6765947). … subunits of the biotin-dependent propionyl-CoA carboxylase (PCC), a mitochondrial enzyme involved in the catabolism of odd chain fatty acids, branched-chain amino acids isoleucine, threonine, methionine, and
Synonyms: Propanoyl-CoA:carbon dioxide ligase subunit betaSolute carrier organic anion transporter family member 1A2
go.drugbank.com/bio_entities/BE0003642TransporterHumansPlays roles in blood-brain and -cerebrospinal fluid barrier transport of organic anions and signal mediators, and in hormone uptake by neural cells (By similarity). … May play an important role in plasma and tissue distribution of the structurally diverse chemotherapeutic drugs methotrexate and paclitaxel (PubMed:23243220).
Synonyms: Sodium-independent organic anion transporterSolute carrier family 23 member 1
go.drugbank.com/bio_entities/BE0000168TransporterTargetHumansHas retained some ancestral activity toward nucleobases such as urate, an oxidized purine.
Synonyms: Sodium-dependent vitamin C transporter 1Immunoglobulin J chain
go.drugbank.com/bio_entities/BE0009083TargetHumansIn the case of IgM, the J chain-joined dimer is a nucleating unit for the IgM pentamer, and in the case of IgA it induces dimers and/or larger polymers.
Synonyms: Joining chain of multimeric IgA and IgMNa(+)/dicarboxylate cotransporter 3
go.drugbank.com/bio_entities/BE0000611TransporterHumansHigh-affinity sodium-dicarboxylate cotransporter that accepts a range of substrates with 4-6 carbon atoms, such as the citric acid cycle intermediates succinate and alpha-ketoglutarate (2-oxoglutarate)
Synonyms: Sodium-dependent high-affinity dicarboxylate transporter 2Prolyl 3-hydroxylase OGFOD1
go.drugbank.com/bio_entities/BE0002210TargetHumansProlyl 3-hydroxylase that catalyzes 3-hydroxylation of 'Pro-62' of small ribosomal subunit uS12 (RPS23), thereby regulating protein translation termination efficiency. Involved in stress granule formation
Synonyms: Termination and polyadenylation 1 homolog, 2-oxoglutarate and iron-dependent oxygenase domain-containing protein 1Isopentenyl-diphosphate Delta-isomerase 1
go.drugbank.com/bio_entities/BE0004044TargetHumansCatalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
Synonyms: Isopentenyl pyrophosphate isomerase 1Acid-sensing ion channel 2
go.drugbank.com/bio_entities/BE0000678TargetHumansHighly selective for sodium, they are permeable to other cations (PubMed:8626462, PubMed:8631835). … By forming heterotrimeric channels with ASIC1, could contribute to synaptic plasticity, learning, and memory.
Synonyms: Brain sodium channel 1Neutral amino acid transporter B(0)
go.drugbank.com/bio_entities/BE0000236TargetTransporterHumansTransports extracellular L-glutamate coupled to the cotransport of one proton and one sodium ion in exchange for intracellular L-glutamine counter-ion. … Displays sodium- and amino acid-dependent but uncoupled channel-like anion conductance with a preference SCN(-) >> NO3(-) > I(-) > Cl(-) (By similarity).
Synonyms: Sodium-dependent neutral amino acid transporter type 2