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Dipivefrin A2-Adrenergic Vasocontriction Action Pathway
smpdb.ca/view/SMP0126098Drug actionDipivefrin is a prodrug of epinephrine used in ophthalmic solutions to reduce intraocular pressure in chronic open-angle glaucoma. It is available as ophthalmic solution (eye drops). Dipivefrin is a prodrug with little or no pharmacologi...
Enzymes: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1Fenobam
go.drugbank.com/drugs/DB12931InvestigationalFenobam is under investigation in clinical trial NCT00637221 (Open Label Study Investigating Safety and Efficacy of Fenobam anhydrous 50 mg - 150 mg on Prepulse Inhibition Tests and Continuous Performance … Tasks, Adults With Fragile X Syndrome).
Categories: Heterocyclic Compounds, 1-RingZanubrutinib
go.drugbank.com/drugs/DB15035ApprovedInvestigationalIn August 2021, the FDA granted accelerated approval to zanubrutinib for the treatment of adults with Waldenström’s macroglobulinemia.[L39030] This indication is valid in the US, Europe, and Canada. … [L10169] It is currently marketed under the trade name BRUKINSA™ and is available as oral capsules.
Categories: P-glycoprotein substrates with a Narrow Therapeutic Index, Cytochrome P-450 CYP2B6 Substrates with a Narrow Therapeutic IndexVaricella zoster vaccine (live/attenuated)
go.drugbank.com/drugs/DB10318ApprovedInvestigationalDecades later, when the body's immune system weakens with age, VZV is able to reactivate and descend through the nerve cells to the surface of the skin where it causes a painful blistering rash, known … While the two vaccines contain the same immunological components and provide protection against the same virus, Zostavax contains a higher dose and is used in older adults to prevent the development of
Mixtures: PRIORIX-TETRA 0.5 ML SC ENJEKSIYON IÇIN LIYOFILIZE TOZ IÇEREN FLAKON VE ÇÖZÜCÜ IÇEREN KULLANIMA HAZIR ENJEKTÖR, 1 DOZ İĞNELİ, PRIORIX-TETRA 0.5 ML SC ENJEKSIYON IÇIN LIYOFILIZE TOZ IÇEREN FLAKON VE ÇÖZÜCÜ IÇEREN KULLANIMA HAZIR ENJEKTÖR, 1 DOZ İĞNESİZSynonyms: Human herpesvirus 3 live (attenuated) antigenMethocarbamol
go.drugbank.com/drugs/DB00423ApprovedInvestigationalVet approvedMethocarbamol was developed in the early 1950s as a treatment for muscle spasticity and the associated pain.[A178441,A178450] It is a guaiacol glyceryl ether. … [Label,L6268] In Canada, methocarbamol can be sold as an over the counter oral medicine at a lower dose that may be combined with [acetaminophen] or [ibuprofen].
Mixtures: Douleurs Musculaires Et Les Courbatures Extra Fort/muscle and Back Pain Relief Extra Strength, Robaxisal C 1/4Synonyms: (RS)-2-hydroxy-3-(2-methoxyphenoxy)propyl carbamateTriplizumab
go.drugbank.com/drugs/DB30669Investigationaltriplizumab is a biologic drug. triplizumab is under investigation in clinical trial NCT06486220 (PFLL Combined With PD-1 Antibody With or Without FMT for Oligometastatic NPC,a Phase III ,Open, Randomized
Bismuth subgallate
go.drugbank.com/drugs/DB13909Approvedinternal deodorant where it is often employed as the primary active ingredient. … Possessing protective effects on the gastric mucosa, strong astringent effects, and not as yet elucidated antimicrobial and hemostatic actions, bismuth subgallate is most commonly available as an over-the-counter
Mixtures: KORTOS KREM, 30 GPergolide Mechanism of Action Action Pathway
smpdb.ca/view/SMP0126635Drug actionThe dopamine D2 receptor is a 7-transmembrane G-protein coupled receptor associated with Gi proteins. In lactotrophs, stimulation of dopamine D2 receptor causes inhibition of adenylyl cyclase, which decreases intracellular cAMP concentra...
Enzymes: Guanine nucleotide-binding protein G(s) subunit alpha isoforms shortGatifloxacin
go.drugbank.com/drugs/DB01044ApprovedInvestigationalWithdrawnGatifloxacin is an antibiotic agent and a member of the fourth-generation fluoroquinolone family. It works by inhibiting the bacterial enzymes DNA gyrase and topoisomerase IV. … Gatifloxacin is available as tablets and in various aqueous solutions for intravenous therapy. It is also available as eye drops under the brand name Zymar® marketed by Allergan.
Mixtures: CARTEOF®, NORIGRAN®Categories: 4-Quinolones, P-glycoprotein substratesDicyclomine
go.drugbank.com/drugs/DB00804ApprovedInvestigationalDicyclomine is a muscarinic M1, M3, and M2 receptor antagonist as well as a non-competitive inhibitor of histamine and bradykinin used to treat spasms of the intestines seen in functional bowel disorder … [A6556,A182555,A234659,L7967] Though it is commonly prescribed, its recommendation may have been based on a small amount of evidence and so its prescription is becoming less favourable.
Mixtures: AXCEL DICYCLOMINE-S SYRUPSynonyms: 2-(diethylamino)ethyl 1-cyclohexylcyclohexanecarboxylate, Bicyclohexyl-1-carboxylic acid 2-diethylamino-ethyl ester